Group Independent Component Analysis (gICA) and Current Source Density (CSD) in the study of EEG in ADHD adults

• Published in: Clinical neurophysiology Vol. 125; no. 1; pp. 83 - 97
• Main Authors: Ponomarev, Valery A., Mueller, Andreas, Candrian, Gian, Grin-Yatsenko, Vera A., Kropotov, Juri D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.01.2014
• Subjects: ADHD; Adult; Attention Deficit Disorder with Hyperactivity - physiopathology; Current Source Density; EEG spectra; Electroencephalography - methods; Eye - physiopathology; Female; Group Independent Component Analysis; Humans; Male; Middle Aged; Neurology; Rest; Young Adult; ADHD; Group Independent Component Analysis; Current Source Density; EEG spectra
• ISSN: 1388-2457; 1872-8952; 1872-8952
• DOI: 10.1016/j.clinph.2013.06.015

•ADHD adults showed reduced EEG activity in the different frequency ranges as compared with healthy subjects.•Spatial pattern of differences depended on whether the eyes were open or closed.•gICA and CSD approaches are probably more sensitive for differentiating the characteristics of EEG spectra in groups of patients/subjects, as compared to spectral analysis of EEG. To investigate the performance of the spectral analysis of resting EEG, Current Source Density (CSD) and group independent components (gIC) in diagnosing ADHD adults. Power spectra of resting EEG, CSD and gIC (19 channels, linked ears reference, eyes open/closed) from 96 ADHD and 376 healthy adults were compared between eyes open and eyes closed conditions, and between groups of subjects. Pattern of differences in gIC and CSD spectral power between conditions was approximately similar, whereas it was more widely spatially distributed for EEG. Size effect (Cohen’s d) of differences in gIC and CSD spectral power between groups of subjects was considerably greater than in the case of EEG. Significant reduction of gIC and CSD spectral power depending on conditions was found in ADHD patients. Reducing power in a wide frequency range in the fronto-central areas is a common phenomenon regardless of whether the eyes were open or closed. Spectral power of local EEG activity isolated by gICA or CSD in the fronto-central areas may be a suitable marker for discrimination of ADHD and healthy adults. Spectral analysis of gIC and CSD provides better sensitivity to discriminate ADHD and healthy adults.