Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

• Published in: Journal of Virology Vol. 80; no. 12; pp. 6146 - 6154
• Main Authors: Le Pogam, Sophie, Kang, Hyunsoon, Harris, Seth F., Leveque, Vincent, Giannetti, Anthony M., Ali, Samir, Jiang, Wen-Rong, Rajyaguru, Sonal, Tavares, Gisele, Oshiro, Connie, Hendricks, Than, Klumpp, Klaus, Symons, Julian, Browner, Michelle F., Cammack, Nick, Nájera, Isabel
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2006
• Subjects: Antiviral Agents - pharmacology; Biological and medical sciences; Carboxylic Acids; Drug Resistance, Viral; Drug Therapy, Combination; Fundamental and applied biological sciences. Psychology; Genetic Variation; Hepacivirus - drug effects; Hepacivirus - enzymology; Hepacivirus - genetics; Hepatitis C virus; Microbiology; Miscellaneous; Mutation, Missense; Replicon - genetics; RNA-Dependent RNA Polymerase - antagonists & inhibitors; Selection, Genetic; Thiophenes - pharmacology; Vaccines and Antiviral Agents; Viral Nonstructural Proteins - antagonists & inhibitors; Virology; Virus Replication; Virus; Resistance; Microbiology; Flaviviridae; Hepatitis C virus; Hepacivirus; Virology
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.02628-05

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