Safety and efficacy of ezetimibe: A meta-analysis

• Published in: International journal of cardiology Vol. 201; pp. 247 - 252
• Main Authors: Savarese, Gianluigi, De Ferrari, Gaetano M., Rosano, Giuseppe M.C., Perrone-Filardi, Pasquale
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 15.12.2015
• Subjects: Anticholesteremic Agents - therapeutic use; Cardiovascular; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - prevention & control; Cardiovascular events; Cholesterol; Cholesterol, LDL - blood; Cholesterol, LDL - drug effects; Ezetimibe; Ezetimibe - therapeutic use; Female; Global Health; Humans; Incidence; Male; Mortality; Risk Factors; Statins; Survival Rate - trends; Treatment Outcome; Cardiovascular events; Mortality; Statins; Cholesterol; Ezetimibe
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2015.08.103

The addition of ezetimibe to statin therapy has been widely demonstrated to significantly reduce low-density lipoprotein cholesterol levels. However, the efficacy of ezetimibe in reducing CV events and its safety has been less investigated. The aim of the current meta-analysis was to report efficacy and safety of ezetimibe from randomized clinical trials. Randomized clinical trials with a follow-up of at least 24weeks, enrolling more than 200 patients, comparing ezetimibe versus placebo or ezetimibe plus another hypolipidemic agent versus the same hypolipidemic drug alone and reporting at least one event among all-cause and CV mortality, myocardial infarction (MI), stroke and new onset of cancer were included in the analysis. 7 trials enrolling 31,048 patients (median follow-up 34.1±26.3months; 70% women; mean age 61±8years) were included in the analysis. Compared to control therapy, ezetimibe significantly reduced the risk of MI by 13.5% (RR: 0.865, 95% CI: 0.801 to 0.934, p<0.001) and the risk of any stroke by 16.0% (RR: 0.840, 95% CI: 0.744 to 0.949, p=0.005), without any effect on all-cause and CV mortality (RR: 1.003, 95% CI: 0.954 to 1.055, p=0.908; RR: 0.958, 95% CI: 0.879 to 1.044, p=0.330; respectively) and risk of new cancer (RR: 1.040, 95% CI: 0.965 to 1.120, p=0.303). Ezetimibe significantly reduces the risk of MI and stroke without any effect on all-cause and CV mortality and risk of cancer.