Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

Delayed cutaneous reactions developed in 12 patients days after initial injection-related symptoms resolved. The reactions, some as severe as grade 3, resolved in a few days with local therapy, and all 12 patients received the second vaccination; 6 had no recurrence of the local reaction, 3 had simi...

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Published inThe New England journal of medicine Vol. 384; no. 13; pp. 1273 - 1277
Main Authors Blumenthal, Kimberly G, Freeman, Esther E, Saff, Rebecca R, Robinson, Lacey B, Wolfson, Anna R, Foreman, Ruth K, Hashimoto, Dean, Banerji, Aleena, Li, Lily, Anvari, Sara, Shenoy, Erica S
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 01.04.2021
Subjects
Antibiotics
Correspondence
COVID-19
COVID-19 Vaccines
Humans
Immunization
Injection
mRNA
Patients
RNA, Messenger
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccines
Viral Vaccines
United States > US
Massachusetts
Online AccessGet full text
ISSN0028-4793
1533-4406
1533-4406
DOI10.1056/NEJMc2102131

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Summary:Delayed cutaneous reactions developed in 12 patients days after initial injection-related symptoms resolved. The reactions, some as severe as grade 3, resolved in a few days with local therapy, and all 12 patients received the second vaccination; 6 had no recurrence of the local reaction, 3 had similar reactions to the initial injection reaction, and 3 had milder reactions.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc2102131