Truncation of the Cytoplasmic Domain Induces Exposure of Conserved Regions in the Ectodomain of Human Immunodeficiency Virus Type 1 Envelope Protein

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Published inJournal of Virology Vol. 76; no. 6; pp. 2683 - 2691
Main Authors Edwards, Terri G., Wyss, Stéphanie, Reeves, Jacqueline D., Zolla-Pazner, Susan, Hoxie, James A., Doms, Robert W., Baribaud, Frédéric
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2002
Subjects
Amino Acid Sequence
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - metabolism
CD4 antigen
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
Cell Line
Conserved Sequence
Env protein
Frameshift Mutation
glycoprotein gp120
glycoprotein gp41
HIV Antibodies - immunology
HIV Antibodies - metabolism
HIV Envelope Protein gp120 - chemistry
HIV Envelope Protein gp120 - genetics
HIV Envelope Protein gp120 - metabolism
HIV Envelope Protein gp41 - chemistry
HIV Envelope Protein gp41 - genetics
HIV Envelope Protein gp41 - immunology
HIV Envelope Protein gp41 - metabolism
HIV-1 - genetics
HIV-1 - immunology
HIV-1 - pathogenicity
Human immunodeficiency virus 1
Humans
Membrane Fusion
Molecular Sequence Data
Neutralization Tests
Pathogenesis and Immunity
Protein Conformation
Protein Structure, Tertiary
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ISSN0022-538X
1098-5514
DOI10.1128/JVI.76.6.2683-2691.2002

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Corresponding author. Mailing address: Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 36th and Hamilton Walk, Philadelphia, PA 19104. Phone: (215) 898-0890. Fax: (215) 898-9557. E-mail: doms@mail.med.upenn.edu.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.76.6.2683-2691.2002