Synthetic biology for Taxol biosynthesis and sustainable production
Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will p...
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| Published in | Trends in biotechnology (Regular ed.) Vol. 42; no. 6; pp. 674 - 676 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.2024
Elsevier Limited |
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| Online Access | Get full text |
| ISSN | 0167-7799 1879-3096 1879-3096 |
| DOI | 10.1016/j.tibtech.2024.04.001 |
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| Abstract | Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology.
Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. |
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| AbstractList | Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. AbstractIncomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology.Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. |
| Author | Xie, Linfeng Zhou, Yongjin J. Gao, Jiaoqi |
| Author_xml | – sequence: 1 givenname: Linfeng orcidid: 0000-0003-4383-6839 surname: Xie fullname: Xie, Linfeng organization: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China – sequence: 2 givenname: Jiaoqi orcidid: 0000-0001-7099-7422 surname: Gao fullname: Gao, Jiaoqi organization: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China – sequence: 3 givenname: Yongjin J. orcidid: 0000-0002-2369-3079 surname: Zhou fullname: Zhou, Yongjin J. email: zhouyongjin@dicp.ac.cn organization: Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38609783$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.isci.2020.100879 10.1007/s00253-023-12713-y 10.1038/s41467-024-45574-8 10.1038/nbt.3095 10.1021/ja00738a045 10.1126/science.adj3484 10.1038/s41467-024-46583-3 10.1016/j.molp.2023.10.016 10.1073/pnas.1515826113 10.1021/jacs.3c10864 10.1038/s41586-022-05157-3 10.1038/s41477-021-00963-5 |
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| Keywords | paclitaxel synthetic biology Taxol biosynthetic pathway |
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| SubjectTerms | antineoplastic agents biochemical pathways Biology Biosynthesis biosynthetic pathway Biosynthetic Pathways biotechnology Cancer Chemical synthesis Cytochrome Enzymes Fungi Genes Genetic engineering Internal Medicine Metabolic engineering Metabolic Engineering - methods Metabolism Metabolites Paclitaxel Paclitaxel - biosynthesis Paclitaxel - metabolism Sustainable development Sustainable production Synthetic biology Synthetic Biology - methods Taxol Yeast |
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| Title | Synthetic biology for Taxol biosynthesis and sustainable production |
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