Synthetic biology for Taxol biosynthesis and sustainable production

• Published in: Trends in biotechnology (Regular ed.) Vol. 42; no. 6; pp. 674 - 676
• Main Authors: Xie, Linfeng, Gao, Jiaoqi, Zhou, Yongjin J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2024; Elsevier Limited
• Subjects: antineoplastic agents; biochemical pathways; Biology; Biosynthesis; biosynthetic pathway; Biosynthetic Pathways; biotechnology; Cancer; Chemical synthesis; Cytochrome; Enzymes; Fungi; Genes; Genetic engineering; Internal Medicine; Metabolic engineering; Metabolic Engineering - methods; Metabolism; Metabolites; Paclitaxel; Paclitaxel - biosynthesis; Paclitaxel - metabolism; Sustainable development; Sustainable production; Synthetic biology; Synthetic Biology - methods; Taxol; Yeast; paclitaxel; synthetic biology; Taxol; biosynthetic pathway
• ISSN: 0167-7799; 1879-3096; 1879-3096
• DOI: 10.1016/j.tibtech.2024.04.001

Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology. Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology.