Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents
The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested in vitro activity, includ...
Saved in:
Published in | Journal of enzyme inhibition and medicinal chemistry Vol. 33; no. 1; pp. 416 - 423 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
ABINGDON
Taylor & Francis
01.01.2018
Taylor & Francis Group |
Subjects | |
Online Access | Get full text |
ISSN | 1475-6366 1475-6374 1475-6374 |
DOI | 10.1080/14756366.2018.1425686 |
Cover
Summary: | The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested in vitro activity, including α-glucosidase inhibitory activity, aldose reductase (AR) inhibitory activity and advanced glycation end products (AGEs) formation inhibitory activity. A class of modified compounds could play a significant effect for treatment of diabetic complications. Target compounds 3e and 7c offered a potential drug design concept for the development of therapeutic or preventive agents for diabetes and its complications. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Supplemental data for this article can be accessed here. |
ISSN: | 1475-6366 1475-6374 1475-6374 |
DOI: | 10.1080/14756366.2018.1425686 |