Existence and consequences of G-quadruplex structures in DNA

While the discovery of B-form DNA 60 years ago has defined our molecular view of the genetic code, other postulated DNA secondary structures, such as A-DNA, Z-DNA, H-DNA, cruciform and slipped structures have provoked consideration of DNA as a more dynamic structure. Four-stranded G-quadruplex DNA d...

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Bibliographic Details
Published inCurrent opinion in genetics & development Vol. 25; pp. 22 - 29
Main Authors Murat, Pierre, Balasubramanian, Shankar
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2014
Subjects
Animals
DNA - chemistry
G-Quadruplexes
Genome
Humans
Medical Education
RNA - chemistry
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ISSN0959-437X
1879-0380
1879-0380
DOI10.1016/j.gde.2013.10.012

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Summary:While the discovery of B-form DNA 60 years ago has defined our molecular view of the genetic code, other postulated DNA secondary structures, such as A-DNA, Z-DNA, H-DNA, cruciform and slipped structures have provoked consideration of DNA as a more dynamic structure. Four-stranded G-quadruplex DNA does not use Watson-Crick base pairing and has been subject of considerable speculation and investigation during the past decade, particularly with regard to its potential relevance to genome integrity and gene expression. Here, we discuss recent data that collectively support the formation of G-quadruplexes in genomic DNA and the consequences of formation of this structural motif in biological processes.
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ISSN:0959-437X
1879-0380
1879-0380
DOI:10.1016/j.gde.2013.10.012