Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes
The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear r...
Saved in:
| Published in | Journal of diabetes investigation Vol. 14; no. 10; pp. 1183 - 1186 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
John Wiley & Sons, Inc
01.10.2023
John Wiley and Sons Inc Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2040-1116 2040-1124 2040-1124 |
| DOI | 10.1111/jdi.14049 |
Cover
| Abstract | The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker.
Relationships between baseline urinary endothelial growth factor and baseline and longitudinal changes in cardiovascular autonomic neuropathy indices were observed. A large‐scale, long‐term study is needed to evaluate if urinary endothelial growth factor can serve as a reliable non‐invasive biomarker of cardiovascular autonomic neuropathy. |
|---|---|
| AbstractList | The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (
n
= 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (
P
= 0.03) and greater annual declines in Valsalva ratios (
P
= 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (
P
= 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (
P
= 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker.
Relationships between baseline urinary endothelial growth factor and baseline and longitudinal changes in cardiovascular autonomic neuropathy indices were observed. A large‐scale, long‐term study is needed to evaluate if urinary endothelial growth factor can serve as a reliable non‐invasive biomarker of cardiovascular autonomic neuropathy. Abstract The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker. The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker. Relationships between baseline urinary endothelial growth factor and baseline and longitudinal changes in cardiovascular autonomic neuropathy indices were observed. A large‐scale, long‐term study is needed to evaluate if urinary endothelial growth factor can serve as a reliable non‐invasive biomarker of cardiovascular autonomic neuropathy. The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort ( n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios ( P = 0.03) and greater annual declines in Valsalva ratios ( P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios ( P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios ( P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker. The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low-frequency power : high-frequency power ratios (P = 0.01) and greater annual changes in low-frequency power : high-frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large-scale, long-term study is needed to validate uEGF as a reliable CAN biomarker. The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low-frequency power : high-frequency power ratios (P = 0.01) and greater annual changes in low-frequency power : high-frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large-scale, long-term study is needed to validate uEGF as a reliable CAN biomarker.The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low-frequency power : high-frequency power ratios (P = 0.01) and greater annual changes in low-frequency power : high-frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large-scale, long-term study is needed to validate uEGF as a reliable CAN biomarker. |
| Author | Tanner, Emily Ang, Lynn Lin, Yu Kuei Ju, Wenjun Pop‐Busui, Rodica Wang, Yuee Ye, Wen |
| AuthorAffiliation | 2 Division of Nephrology, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA 1 Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA 3 Department of Biostatistics, School of Public Health University of Michigan Ann Arbor Michigan USA |
| AuthorAffiliation_xml | – name: 1 Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA – name: 2 Division of Nephrology, Department of Internal Medicine University of Michigan Ann Arbor Michigan USA – name: 3 Department of Biostatistics, School of Public Health University of Michigan Ann Arbor Michigan USA |
| Author_xml | – sequence: 1 givenname: Yu Kuei orcidid: 0000-0003-1988-7046 surname: Lin fullname: Lin, Yu Kuei email: yuklin@med.umich.edu organization: University of Michigan – sequence: 2 givenname: Emily surname: Tanner fullname: Tanner, Emily organization: University of Michigan – sequence: 3 givenname: Yuee surname: Wang fullname: Wang, Yuee organization: University of Michigan – sequence: 4 givenname: Wen surname: Ye fullname: Ye, Wen organization: University of Michigan – sequence: 5 givenname: Lynn surname: Ang fullname: Ang, Lynn organization: University of Michigan – sequence: 6 givenname: Wenjun surname: Ju fullname: Ju, Wenjun organization: University of Michigan – sequence: 7 givenname: Rodica surname: Pop‐Busui fullname: Pop‐Busui, Rodica organization: University of Michigan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37395013$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9ks1uEzEQx1eoiJbSAy-AVuICh7T-2qz3hFD5KqrEhZ6tWXucOHLWwfYmyg1x4zV5EpymRLQSzGUsz39-nvHM0-poCANW1XNKzmmxi4Vx51QQ0T2qThgRZEIpE0eHM50eV2cpLUgxLuV02j6pjnnLu4ZQflL9uIlugLitceUMxiX4ehbDJs9rCzqHWHtco0-1DjGih4z1xpWghmhcWEPSo4dYw5jDEJZO1wOOMawgz7e1G4zTmIqvwYw-p31q3q7w1_eftDYOesyYnlWPLfiEZ3f-tLr58P7r5afJ9ZePV5dvrye64aKbGCS6ow0I0ktuibRmaoURuqdWWk5YSxlo1nBqsJc9GNkhBd01YG3LDPT8tLrac02AhVpFtyx9qwBO3V6EOFMQs9MeFQNOwFhJaMdENzWSN60lWkgJ090ThfVmz1qN_RKNxiFH8Peg9yODm6tZWCtKGso6wgrh1R0hhm8jpqyWLmn0HgYMY1JMciYF4R0v0pcPpIswxqH8VVGVgYq2FTvgi79LOtTyZ9ZF8Hov0DGkFNEeJJSo3SqpskrqdpWK9uKBVrsM2YVdN87_L2PjPG7_jVaf313tM34DOwzdbQ |
| CitedBy_id | crossref_primary_10_1111_jdi_14201 |
| Cites_doi | 10.2215/CJN.11441114 10.1016/j.autneu.2020.102646 10.1177/2048004016677687 10.1016/j.jdiacomp.2016.03.008 10.2337/dc16-2042 10.1007/s11906-015-0571-z 10.2337/db19-0145 10.1016/j.diabres.2021.108945 10.1126/scitranslmed.aac7071 |
| ContentType | Journal Article |
| Copyright | 2023 The Authors. published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. 2023. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2023 The Authors. published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. – notice: 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. – notice: 2023. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T5 7TM 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH H94 K9. M0S PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1111/jdi.14049 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts Immunology Abstracts ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 5 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | uEGF associates with CAN indices |
| EISSN | 2040-1124 |
| EndPage | 1186 |
| ExternalDocumentID | oai_doaj_org_article_2a30adf80192496d8357f0c488a62531 PMC10512902 37395013 10_1111_jdi_14049 JDI14049 |
| Genre | shortCommunication Journal Article |
| GrantInformation_xml | – fundername: National Institute of Diabetes and Digestive and Kidney Diseases funderid: K23DK129724; R01DK107956; R01DK116723; U01DK119083 – fundername: Juvenile Diabetes Research Foundation United States of America, Center of Excellence at University of Michigan – fundername: Michigan Medicine‐Peking University Health Science Center Joint Institute for Translational and Clinical Research – fundername: NIDDK NIH HHS grantid: R01DK116723 – fundername: NIDDK NIH HHS grantid: U01DK119083 – fundername: NIDDK NIH HHS grantid: R01DK107956 – fundername: NIDDK NIH HHS grantid: U01 DK119083 – fundername: NIDDK NIH HHS grantid: K23DK129724 – fundername: NIDDK NIH HHS grantid: P30 DK092926 – fundername: NIDDK NIH HHS grantid: R01 DK107956 – fundername: NIDDK NIH HHS grantid: K23 DK129724 – fundername: NIDDK NIH HHS grantid: R01 DK116723 – fundername: ; – fundername: ; grantid: K23DK129724; R01DK107956; R01DK116723; U01DK119083 |
| GroupedDBID | --- 05W 0R~ 1OC 24P 31~ 4.4 50Y 5DZ 5VS 7X7 8-0 8-1 8FI 8FJ AAMMB AANHP AAZKR ABDBF ABJNI ABUWG ACBWZ ACCMX ACGFO ACPRK ACRPL ACUHS ACXQS ACYXJ ADBBV ADKYN ADNMO ADPDF ADRAZ ADZMN AEFGJ AEGXH AENEX AFKRA AGQPQ AGXDD AHMBA AIAGR AIDQK AIDYY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS ASPBG AVUZU AVWKF AZFZN BAWUL BCNDV BDRZF BENPR BPHCQ BVXVI CAG CCPQU COF DIK EBD EBS EJD FYUFA GODZA GROUPED_DOAJ GX1 HMCUK HYE HZ~ KQ8 LH4 LW6 M48 MY. O9- OK1 OVD PHGZM PHGZT PIMPY PQQKQ PROAC RPM RX1 SUPJJ TEORI UKHRP AAHHS AAYXX ACCFJ AEEZP AEQDE AIWBW AJBDE CITATION CGR CUY CVF ECM EIF NPM WIN 3V. 7T5 7TM 7XB 8FK AZQEC DWQXO H94 K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c5349-de0c915a40b83f08fd6f4d4cb1f8f302712ac2531deb8bad89e1ac95aff72dab3 |
| IEDL.DBID | 24P |
| ISSN | 2040-1116 2040-1124 |
| IngestDate | Wed Aug 27 01:02:20 EDT 2025 Thu Aug 21 18:36:33 EDT 2025 Fri Sep 05 04:58:36 EDT 2025 Wed Aug 13 09:32:14 EDT 2025 Wed Feb 19 02:05:34 EST 2025 Tue Jul 01 02:48:51 EDT 2025 Thu Apr 24 23:09:10 EDT 2025 Sun Jul 06 04:44:59 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Type 1 diabetes Endothelial growth factor Cardiovascular autonomic neuropathy |
| Language | English |
| License | Attribution-NonCommercial 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5349-de0c915a40b83f08fd6f4d4cb1f8f302712ac2531deb8bad89e1ac95aff72dab3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-1988-7046 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjdi.14049 |
| PMID | 37395013 |
| PQID | 2866747742 |
| PQPubID | 1006415 |
| PageCount | 1186 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2a30adf80192496d8357f0c488a62531 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10512902 proquest_miscellaneous_2832840393 proquest_journals_2866747742 pubmed_primary_37395013 crossref_primary_10_1111_jdi_14049 crossref_citationtrail_10_1111_jdi_14049 wiley_primary_10_1111_jdi_14049_JDI14049 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | October 2023 |
| PublicationDateYYYYMMDD | 2023-10-01 |
| PublicationDate_xml | – month: 10 year: 2023 text: October 2023 |
| PublicationDecade | 2020 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan – name: Richmond – name: Hoboken |
| PublicationTitle | Journal of diabetes investigation |
| PublicationTitleAlternate | J Diabetes Investig |
| PublicationYear | 2023 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2017; 40 2016; 5 2020; 225 2016; 30 2015; 17 2021; 178 2015; 7 2019; 68 2015; 10 e_1_2_7_6_1 e_1_2_7_11_1 e_1_2_7_5_1 e_1_2_7_10_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_2_1 |
| References_xml | – volume: 7 year: 2015 article-title: Tissue transcriptome‐driven identification of epidermal growth factor as a chronic kidney disease biomarker publication-title: Sci Transl Med – volume: 40 start-page: 136 year: 2017 end-page: 154 article-title: Diabetic neuropathy: A position statement by the American Diabetes Association publication-title: Diabetes Care – volume: 178 year: 2021 article-title: The next generation: Urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus publication-title: Diabetes Res Clin Pract – volume: 17 start-page: 59 year: 2015 article-title: Cardiovascular autonomic dysfunction in chronic kidney disease: A comprehensive review publication-title: Curr Hypertens Rep – volume: 225 year: 2020 article-title: Cardiovascular autonomic neuropathy: A silent killer with long reach publication-title: Auton Neurosci – volume: 30 start-page: 873 year: 2016 end-page: 879 article-title: Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes publication-title: J Diabetes Complications – volume: 68 start-page: 2035 year: 2019 end-page: 2044 article-title: Impaired amino acid and TCA metabolism and cardiovascular autonomic neuropathy progression in type 1 diabetes publication-title: Diabetes – volume: 10 start-page: 1136 year: 2015 end-page: 1144 article-title: Cardiac autonomic neuropathy and early progressive renal decline in patients with Nonmacroalbuminuric type 1 diabetes publication-title: Clin J Am Soc Nephrol – volume: 5 year: 2016 article-title: Neurological complications in chronic kidney disease publication-title: JRSM Cardiovasc Dis – ident: e_1_2_7_6_1 doi: 10.2215/CJN.11441114 – ident: e_1_2_7_11_1 doi: 10.1016/j.autneu.2020.102646 – ident: e_1_2_7_10_1 – ident: e_1_2_7_7_1 doi: 10.1177/2048004016677687 – ident: e_1_2_7_8_1 doi: 10.1016/j.jdiacomp.2016.03.008 – ident: e_1_2_7_2_1 doi: 10.2337/dc16-2042 – ident: e_1_2_7_5_1 doi: 10.1007/s11906-015-0571-z – ident: e_1_2_7_9_1 doi: 10.2337/db19-0145 – ident: e_1_2_7_4_1 doi: 10.1016/j.diabres.2021.108945 – ident: e_1_2_7_3_1 doi: 10.1126/scitranslmed.aac7071 |
| SSID | ssj0000388667 |
| Score | 2.3018317 |
| Snippet | The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated.... Abstract The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1183 |
| SubjectTerms | Adult Alcohol Autonomic Nervous System Autonomic Nervous System Diseases - complications Autonomic Nervous System Diseases - diagnosis Biomarkers Biomarkers - urine Body mass index Cardiovascular autonomic neuropathy Creatinine Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetic Neuropathies - etiology Diabetic neuropathy Endothelial growth factor Epidermal growth factor Epidermal Growth Factor - urine Female Hemoglobin Humans Male Middle Aged Ratios Short Report Standard deviation Type 1 diabetes Urine Young Adult |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4k2gVAZx6CXg2E7qHEuhKpXKiZV6i8YvutIqrbq7B26IG3-TX9IZOxttRBEXTnk5imOP7c_z-Iaxt742IIEsrI31pQ5VU4IyonR4aRpba5dUF2dfmpOZPj2vz7dSfZFPWKYHzg33XoIS4KMRaafQeEQMB1E4lDtA6J4iqKVoxdZmKs3BypgmpY-V5DKHA7oZaIWSG4-fvyNamXayGCXO_tuA5p_-kts4Ni1Exw_Y_QFB8sNc84fsTugfsbtng438Mfs5u04xtjxQ8lecdxf8G-61Vxc859bhC_ITWnJHeTkWCDU56WK5mzimclivcsQyT4yXlLj4Oyf7Ns4reOSJt2OZXyU17u8fvyq-UeQ-YbPjT1-PTsoh00LpaqXb0gfh2qoGLaxRUZjom6i9draKJpJls5LgqLV9sMaCN22owLU1xHggPVj1lO30l314znjUlVXOGQpo1UZbAAHa41RiQ9AKYsH2N03euYGGnLJhLLpxO-LnXeqdgr0Zi15l7o3bCn2gfhsLEF12uoFC1A1C1P1LiAq2u-n1bhjDy06SBGmEx7Jgr8fHOPrIpAJ9uFxTGYXrO8U3F-xZFpKxJopsoIiwC2Ym4jOp6vRJP79IDN8Iekk_iB_eT5L299_vTj9-Ticv_kc7vGT3JIK47Ky4y3ZW1-vwCkHXyu6l8XUDKl4q8g priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSIgL4k1KQQZx6CWQxI7XOSFeValUTqy0t2j8aldaZcs-DtwqbvxNfgkzjjcQUTjtI14lXnvGn2fG38fYS1drqIAyrMq4XPpS5SB0kVv8qJWppY2hi9PP6ngqT2b1LAXc1qmscucTo6N2S0sx8teVVgqhL-7k3lx8zUk1irKrSULjOrtRIhIh6YbJbDLEWIjpREUR2YoK59CsVSIXisU8bv6KyGWa0ZIUmfuvgpt_V03-iWbjcnR0h91OOJK_7Qf-Lrvmu3vs5mnKlN9n36ereNKWe5KARe-74Ge4496c815hhy-oWmjNLalzLBBwcorIcjsqT-Ww3fTnlnnkvST54m-cstzoXfCVR_aOdf9TCub-vPxR8l049wGbHn388v44T3oLua2FbHLnC9uUNcjCaBEKHZwK0klryqAD5TfLCmyFRuu80QacbnwJtqkhhEnlwIiHbK9bdv4x40GWRlir6Vir1NIAFCAdOhTjvRQQMna4-8tbm8jISRNj0Q6bEjdv4-hk7MXQ9KJn4Liq0Tsat6EBkWbHL5arszbZYFuBKMAFXcRNp3IIPiehsOjCQFG3MnawG_U2WfK6_T3vMvZ8uIw2SIkV6PxyS20ErvJ0yjljj_pJMjyJoEwo4uyM6dH0GT3q-Eo3P4883wh9KUqINz6MM-3f3W9PPnyKb_b_34Un7FaFIK0vRjxge5vV1j9FULUxz6Ll_AIp-CPq priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Jb9UwEB6VIiEuiJ2Uggzi0EuqxHZS54AQW1UqlRNP6i3y2j4pyoO3SO0NceNv8kuYcRYR8ZA4ZRsrTjwz_jwzngF45QqluSYPa2lcKn1eplqoLLV4qUpTSBtNF2efy5OZPD0vzndgqLHZ_8DV1qUd1ZOaLZvDq2_Xb1DgX49ROW5-SFliqhtwM7qJKIKvR_lRIQulylhLllP8HDYp-xxDk9aTmSkm8N-GOv8OnvwT1MZZ6fgu3OnhJHvbjf892PHtfbh11jvMH8CP2TJuuGWeKsGiEm7YBS6815esK7TDGgoaWjFLRToaxJ2MDLPMTqJUmd6su-3LLKa_pCrG14yc3ahk8MhiEo9V15Rsur--_8zZYNV9CLPjj1_en6R92YXUFkJWqfOZrfJCy8woETIVXBmkk9bkQQVyc-ZcW46y67xRRjtV-VzbqtAhHHGnjXgEu-2i9U-ABZkbYa2i3a1SSaN1pqVDvWK8l0KHBA6GX17bPic5lcZo6nFt4uZ1HJ0EXo6kX7tEHNuI3tG4jQSUOzveWCwv6l4Ua65Fpl1QWVx7lg4x6FHILGoyXdJnJbA_jHo98GPNiYMkYmWewIvxMYoi-Vd06xcbohE42dNm5wQed0wy9kSQQxThdgJqwj6Trk6ftPPLmO4bETAZC_HFB5HT_v359emHT_Fk7_9Jn8Jtjriti0_ch931cuOfIc5am-dRin4D3XcofQ priority: 102 providerName: Scholars Portal |
| Title | Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjdi.14049 https://www.ncbi.nlm.nih.gov/pubmed/37395013 https://www.proquest.com/docview/2866747742 https://www.proquest.com/docview/2832840393 https://pubmed.ncbi.nlm.nih.gov/PMC10512902 https://doaj.org/article/2a30adf80192496d8357f0c488a62531 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEB6VVkJcEG8MJVoQh16M7N21sxYnCq1KpVQVIlJu1j7bSJGD8jhwQ9z4m_wSZtYPNaJIXOzEnlXs7MzutzOz3wC8dYXSXFOEtTQulT4vUy1Ullr8qkpTSBtdF5OL8mwqz2fFbA_e93thWn6IweFGlhHHazJwbdY3jdzN3xE3THUHDhDUC1JvLi8HBwvRnJSxgiynrDlsVHbMQjGTp2-9Mx9F2v7bsObfKZM3oWyci04fwP0ORLIPba8_hD3fPIK7ky5M_hh-Tldxmy3zVP8Vh94Fu8Ll9uaateV12IJShdbMUmmOBaJNRu5YZndyU5nebtpNyyySXlLt4u-MQtw4tOCZReqOdduUPLm_f_zKWe_LfQLT05OvH8_SrthCagshq9T5zFZ5oWVmlAiZCq4M0klr8qACBTdzri1Hi3XeKKOdqnyubVXoEMbcaSOewn6zbPxzYEHmRliraE-rVNJonWnpcDQx3kuhQwJH_V9e246JnApiLOphReLmdeydBN4Mot9a-o3bhI6p3wYBYsyOF5arq7ozwJprkWkXVBZXnKVD5DkOmcXxS5f0Wgkc9r1ed2a8rjlpkESEzBN4PdxGA6Soim78cksyAqd42uKcwLNWSYYnERQGRZCdgNpRn51H3b3TzK8jyTfiXnIR4g8fRU379-vX558-xw8v_l_0JdzjiNbarMRD2N-stv4VoquNGUUrwuN4Nh7BwfHJxeWXUfRU4HEi1R-cZCge |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9NAFH4qRQIuiB1DgQGB1IuLl_FkckAIKFXSNj01Um5m1jZSlJQsQr0hbvwZfhS_hPfGC0QUbj3FsSeJJ2_x93aAl7aQKlMUYRXaxtylIla5TGKDb6XQBTfBdTE4Er0h3x8Vow340dTCUFploxODorYzQz7y15kUAqEvWnJvzz7HNDWKoqvNCI2KLQ7c-Rc02RZv-rtI31dZtvfx-EMvrqcKxKbIeTe2LjHdtFA80TL3ifRWeG650amXnqJ4aaZMhqxpnZZaWdl1qTLdQnnfyazSOX7vFbjKKcSI8tMZdVqfDnVWEWFobUaJeqhGRN3MKCQP2fEONbPprj0Cw6SAi-Dt31maf6Ln8PjbuwU3a9zK3lWMdhs23PQOXBvUkfm78G04D5W9zNHIWdT2E3aCFv7ylFUTfdiEspMWzNA0kAkCXEYeYGbW0mGZWi2rOmkW-mzSuORzRlF11Gb4ykK3kEX1UXIe__z6PWWN-_geDC-FEvdhczqbuofAPE91boykMlouuVYqUdyiAtPO8Vz5CLabv7w0dfNzmsExKVsjyI7LQJ0IXrRLz6qOHxctek90axdQk-5wYjY_KWuZLzOVJ8p6mQQjV1gEux2fGFSZStC2IthqqF7WmmNR_ubzCJ63l1HmKZCjpm62ojU5ogqqqo7gQcUk7Z3kFHlFXB-BXGOftVtdvzIdn4a-4gi1ySuJP7wdOO3f2y_3d_vh4NH_t_AMrveOB4flYf_o4DHcyBAgVomQW7C5nK_cEwR0S_00SBGDT5cttr8AcVhinw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3JbhNBEC2FIEVcEHsGAjQIpFyGzNLTbh8QAowVJyTigCXfhl4TS5YdvAjlhrjxS3wOX0JVzwIWgVtOHs-07WnXMq-rqusBPLOFVJmiDKvQNuYuFbHKZRIbfCuFLrgJoYujY7E_5AejYrQBP5q9MFRW2fjE4KjtzFCMfC-TQiD0xZXcnq_LIj70-q_OPsfEIEWZ1oZOo1KRQ3f-BZdvi5eDHsr6eZb13318ux_XDAOxKXLeja1LTDctFE-0zH0ivRWeW2506qWnjF6aKZOhmlqnpVZWdl2qTLdQ3ncyq3SO33sFrnZyzok2ojPqtPEd6rIiAoFtRkV76FJE3dgoFBLZ8QtqbNNdexwG1oCLoO7fFZt_IunwKOzfgOs1hmWvK6W7CRtuegu2juos_W34NpyHXb7MEf0sev4JO8HV_vKUVew-bEKVSgtmiBlkgmCXUTSYmbXSWKZWy2rPNAs9N4k6-ZxRhh09G76y0DlkUX2UAsk_v35PWRNKvgPDS5HEXdiczqZuG5jnqc6NkbSllkuulUoUt-jMtHM8Vz6C3eYvL03dCJ34OCZluyCy4zJIJ4Kn7dCzqvvHRYPekNzaAdSwO5yYzU_K2v7LTOWJsl4mYcErLALfjk8Muk8laFoR7DRSL2svsih_63wET9rLaP-U1FFTN1vRmBwRBu2wjuBepSTtneSUhUWMH4FcU5-1W12_Mh2fhh7jCLspQok_vBs07d_TLw96g3Bw__9TeAxbaLDl-8Hx4QO4liFWrGoid2BzOV-5h4jtlvpRMCIGny7ban8BrtBm0g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Urinary+epidermal+growth+factor+levels+correlate+with+cardiovascular+autonomic+neuropathy+indices+in+adults+with+type%E2%80%891+diabetes&rft.jtitle=Journal+of+diabetes+investigation&rft.au=Lin%2C+Yu+Kuei&rft.au=Tanner%2C+Emily&rft.au=Wang%2C+Yuee&rft.au=Ye%2C+Wen&rft.date=2023-10-01&rft.issn=2040-1116&rft.eissn=2040-1124&rft.volume=14&rft.issue=10&rft.spage=1183&rft.epage=1186&rft_id=info:doi/10.1111%2Fjdi.14049&rft.externalDBID=10.1111%252Fjdi.14049&rft.externalDocID=JDI14049 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2040-1116&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2040-1116&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2040-1116&client=summon |