Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes

• Published in: Journal of diabetes investigation Vol. 14; no. 10; pp. 1183 - 1186
• Main Authors: Lin, Yu Kuei, Tanner, Emily, Wang, Yuee, Ye, Wen, Ang, Lynn, Ju, Wenjun, Pop‐Busui, Rodica
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01.10.2023; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Alcohol; Autonomic Nervous System; Autonomic Nervous System Diseases - complications; Autonomic Nervous System Diseases - diagnosis; Biomarkers; Biomarkers - urine; Body mass index; Cardiovascular autonomic neuropathy; Creatinine; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - complications; Diabetic Neuropathies - etiology; Diabetic neuropathy; Endothelial growth factor; Epidermal growth factor; Epidermal Growth Factor - urine; Female; Hemoglobin; Humans; Male; Middle Aged; Ratios; Short Report; Standard deviation; Type 1 diabetes; Urine; Young Adult; Type 1 diabetes; Endothelial growth factor; Cardiovascular autonomic neuropathy
• ISSN: 2040-1116; 2040-1124; 2040-1124
• DOI: 10.1111/jdi.14049

The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker. Relationships between baseline urinary endothelial growth factor and baseline and longitudinal changes in cardiovascular autonomic neuropathy indices were observed. A large‐scale, long‐term study is needed to evaluate if urinary endothelial growth factor can serve as a reliable non‐invasive biomarker of cardiovascular autonomic neuropathy.