Increased expression of TRPV1 in patients with acute or chronic cough after lung cancer surgery

• Published in: Thoracic cancer Vol. 10; no. 4; pp. 988 - 991
• Main Authors: Zhu, Yong‐fu, Wu, Sheng‐bing, Zhou, Mei‐qi, Xie, Ming‐ran, Xiong, Ran, Xu, Shi‐bin, Xu, Guang‐wen
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.04.2019; John Wiley & Sons, Inc; Wiley
• Subjects: Acute cough; Aged; Bradykinin - metabolism; Cancer surgery; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - surgery; chronic cough; Cough - ethnology; Cough - metabolism; Dinoprostone - metabolism; Enzymes; Female; Humans; Inflammation; lobectomy; Lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - surgery; Lymphatic system; Male; Medical research; Middle Aged; Original; Ostomy; Patients; Postoperative Complications - metabolism; Respiratory diseases; Studies; Thoracic surgery; TRPV Cation Channels - metabolism; TRPV1; Up-Regulation; Visual Analog Scale; China; Acute cough; lung cancer; lobectomy; TRPV1; chronic cough
• ISSN: 1759-7706; 1759-7714; 1759-7714
• DOI: 10.1111/1759-7714.13042

Background We investigated preoperative and postoperative TRPV1, bradykinin (BK), and prostaglandin e‐2 (PGE2) levels in patients who underwent lung cancer surgery and evaluated the correlations between these levels and the development of acute or chronic cough after surgery. Methods We evaluated 60 patients with non‐small cell lung cancer who underwent lobectomy at our center between August and October 2018. TRPV1, BK, and PGE2 levels were determined by enzyme‐linked immunosorbent assay and postoperative cough was assessed using the visual analog scale (VAS). Results The postoperative serum TRPV1, BK, and PEG2 levels of the 60 patients were significantly higher than the preoperative levels (P < 0.001). Thirty‐five patients (58.3%) were diagnosed with acute cough (VAS ≥ 60 mm), and 25 were diagnosed with non‐acute cough (41.7%). Three days after surgery, the serum TRPV1, BK, and PGE2 levels were significantly higher in the acute cough group than in the non‐acute cough group (P < 0.001). Twenty‐two patients (36.7%) were diagnosed with chronic cough (VAS ≥ 60 mm), and 25 (62.3%) were diagnosed with non‐chronic cough. Eight weeks after surgery, the serum TRPV1, BK, and PGE2 levels were significantly higher in the chronic cough group than in the non‐chronic cough group (P < 0.05). Conclusions The postoperative TRPV1, BK and PGE2 levels were significantly higher than the preoperative levels. The TRPV1 level was also higher in patients with an acute or chronic cough than in patients without. Postoperative acute or chronic cough symptoms can be improved and alleviated by blocking the TRPV1 pathway.