The thalamus: Structure, function, and neurotherapeutics

• Published in: Neurotherapeutics Vol. 22; no. 2; p. e00550
• Main Authors: Marcuse, Lara V., Langan, Mackenzie, Hof, Patrick R., Panov, Fedor, Saez, Ignacio, Jimenez-Shahed, Joohi, Figee, Martijn, Mayberg, Helen, Yoo, Ji Yeoun, Ghatan, Saadi, Balchandani, Priti, Fields, Madeline C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025; Elsevier
• Subjects: Animals; Coma; Current s; Drug-resistant epilepsy; Epilepsy - physiopathology; Epilepsy - therapy; Humans; Neuromodulation; Thalamus; Thalamus - anatomy & histology; Thalamus - physiology; Tourette's syndrome; Tremor; Coma; Tourette's syndrome; Thalamus; Drug-resistant epilepsy; Tremor; Neuromodulation
• ISSN: 1878-7479; 1933-7213; 1878-7479
• DOI: 10.1016/j.neurot.2025.e00550

The complexity and expansive nature of thalamic research has led to numerous interventions for varied disease states. At the same time, this complexity along with siloed areas of study can hinder a comprehensive understanding. The goal of this paper is to give the reader a broader and more detailed perspective on the thalamus. In order to accomplish this goal, the paper begins with a summary of the function, electrophysiology, and anatomy of the normal thalamus. With this foundation, thalamic involvement in neurological diseases is discussed with a focus on epilepsy. Therapeutic interventions in the thalamus for epilepsy as well as movement disorders, psychiatric conditions and disorders of consciousness are described. Lastly limitations in the field and future models of data sharing and cooperation are explored.