Incremental Value of Late Gadolinium Enhancement for Management of Patients With Hypertrophic Cardiomyopathy

Cardiac magnetic resonance with late gadolinium enhancement (LGE) is a well-established method for in vivo detection of myocardial scarring. Several recent studies have investigated the prognostic value of LGE in patients with hypertrophic cardiomyopathy (HC). We discuss the prevalence and patterns...

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Bibliographic Details
Published inThe American journal of cardiology Vol. 110; no. 8; pp. 1207 - 1212
Main Authors Greulich, Simon, Schumm, Julia, Grün, Stefan, Bruder, Oliver, Sechtem, Udo, Mahrholdt, Heiko
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.10.2012
Elsevier
Elsevier Limited
Subjects
Biological and medical sciences
Cardiac arrhythmia
Cardiology. Vascular system
Cardiomyopathy, Hypertrophic - pathology
Cardiovascular
Cardiovascular disease
Contrast Media
Decision making
Gadolinium
Heart
Heart attacks
Humans
Magnetic Resonance Imaging - methods
Medical sciences
Mortality
Myocarditis. Cardiomyopathies
Practice Guidelines as Topic
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Studies
Survival Analysis
Human
Late
Clinical management
Heart disease
Hypertrophic cardiomyopathy
Cardiovascular disease
Gadolinium
Patient
Circulatory system
Cardiology
Myocardial disease
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ISSN0002-9149
1879-1913
1879-1913
DOI10.1016/j.amjcard.2012.05.064

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Summary:Cardiac magnetic resonance with late gadolinium enhancement (LGE) is a well-established method for in vivo detection of myocardial scarring. Several recent studies have investigated the prognostic value of LGE in patients with hypertrophic cardiomyopathy (HC). We discuss the prevalence and patterns of scarring in HC and its pathophysiologic significance, with focus on ventricular arrhythmias and sudden cardiac death. The available evidence that myocardial scar demonstrated by LGE is a good independent predictor of cardiac mortality in HC is summed up. Recommendations of current guidelines for prevention of sudden cardiac death in HC are discussed with regard to recent results, and the significance of LGE as an emerging risk factor is pointed out. In conclusion, it is demonstrated that LGE has incremental value in addition to clinical risk factors for risk stratification and management of patients with HC.
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ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2012.05.064