Paclitaxel-Eluting versus Uncoated Stents in Primary Percutaneous Coronary Intervention

• Published in: The New England journal of medicine Vol. 355; no. 11; pp. 1105 - 1113
• Main Authors: Laarman, Gerrit J, Suttorp, Maarten J, Dirksen, Maurits T, van Heerebeek, Loek, Kiemeneij, Ferdinand, Slagboom, Ton, van der Wieken, L. Ron, Tijssen, Jan G.P, Rensing, Benno J, Patterson, Mark
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 14.09.2006
• Subjects: Angioplasty; Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiology. Vascular system; Combined Modality Therapy; Coronary Angiography; Coronary Artery Bypass; Coronary heart disease; Disease-Free Survival; Female; Follow-Up Studies; General aspects; Heart; Heart attacks; Humans; Immunosuppressive Agents - administration & dosage; Male; Medical imaging; Medical sciences; Middle Aged; Myocardial Infarction - mortality; Myocardial Infarction - therapy; Paclitaxel - administration & dosage; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors; Proportional Hazards Models; Risk; Secondary Prevention; Single-Blind Method; Stents; Thrombosis - epidemiology; Veins & arteries; Antineoplastic agent; Angioplasty; Coronary artery; Instrumentation therapy; Cardiovascular disease; Coronary heart disease; Medicine; Taxane derivatives; Paclitaxel; Primary; Antimitotic; Drug eluting stent; Comparative study
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa062598

The Paclitaxel-Eluting Stent versus Conventional Stent in Myocardial Infarction with ST-Segment Elevation (PASSION) trial compared the use of paclitaxel-eluting stents with uncoated stents for primary percutaneous coronary intervention in patients with acute myocardial infarction with ST-segment elevation. Although the paclitaxel-eluting stent was associated with a trend toward fewer serious adverse cardiac events, the trend was not significant. The paclitaxel-eluting stent was associated with a trend toward fewer serious adverse cardiac events, but the trend was not significant. Primary percutaneous coronary intervention (PCI) is now considered the optimal approach to the management of myocardial infarction with ST-segment elevation when the procedure is performed expeditiously and at a high-volume center. 1 – 5 Stent implantation is associated with an improvement in both early and late outcomes, as compared with balloon angioplasty alone, predominantly as a result of a reduction in target-vessel revascularization. 6 , 7 Furthermore, drug-eluting stents have been shown to reduce in-stent restenosis (and therefore the need for repeated intervention) in a number of subgroups of patients. 8 , 9 Retrospective studies and one small, randomized trial have suggested that the use of . . .