Preliminary Study on Reference Interval of Serum Pepsinogen in Healthy Subjects

• Published in: Patient preference and adherence Vol. 15; pp. 2725 - 2730
• Main Authors: Zhang, Liang, Niu, Ye, Lv, Yin-Jiang, Wu, Li-Feng, Hu, Qi-Lei, Huang, Rong, Xu, Ru-Jin
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Age groups; Alcohol; Biopsy; Cancer; chemiluminescent microparticle immunoassay; clsi-c28-a3; Diagnosis; Females; Gastric cancer; Gender; Health aspects; Immunoassay; Infections; Inflammation; Measurement; Medical screening; Original Research; Pepsinogen; Reagents; reference interval; Risk factors; Serology; Statistical analysis; Stomach cancer; China; CLSI-C28-A3; chemiluminescent microparticle immunoassay; pepsinogen; reference interval
• ISSN: 1177-889X; 1177-889X
• DOI: 10.2147/PPA.S330656

This study determined the reference interval of pepsinogen (PG) of healthy people in the local region to provide a basis for early screening of gastric cancer. Among the healthy people who underwent a physical examination in our hospital from January 2020 to December 2020, 2568 subjects were selected based on the relevant screening criteria. Their serum PG I and II levels and PG I:PG II ratio were determined by chemiluminescent microparticle immunoassay (CIMA), and the results were statistically analyzed. Finally, according to document CLSI-C28-A3, the PG reference interval of the local region was determined. The PG I and II levels of the males in all age groups were higher than those of the females in the corresponding age groups, and the differences were statistically significant (P < 0.05). However, the differences in the PG I:PG II ratio between the genders in the different age groups were not statistically significant (P > 0.05). The PG I and II levels increased with age in both men and women, while the PG I:PG II ratio was not correlated with age in either gender. The PG reference interval of the local region was initially determined as providing a reliable reference basis for clinical treatment.