The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial
Aim To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n...
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Published in | Journal of clinical periodontology Vol. 41; no. 9; pp. 875 - 882 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.09.2014
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Subjects | |
Online Access | Get full text |
ISSN | 0303-6979 1600-051X 1600-051X |
DOI | 10.1111/jcpe.12290 |
Cover
Abstract | Aim
To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.
Material and Methods
A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).
Results
After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C‐reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).
Conclusions
The non‐surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis. |
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AbstractList | Aim
To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.
Material and Methods
A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).
Results
After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C‐reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).
Conclusions
The non‐surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis. To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis. To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.AIMTo determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).MATERIAL AND METHODSA total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).RESULTSAfter 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.CONCLUSIONSThe non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis. Aim To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). Results After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). Conclusions The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis. [PUBLICATION ABSTRACT] |
Author | Caúla, André Luis Lira-Junior, Ronaldo Tinoco, Eduardo Muniz Barretto Fischer, Ricardo Guimarães |
Author_xml | – sequence: 1 givenname: André Luis surname: Caúla fullname: Caúla, André Luis organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil – sequence: 2 givenname: Ronaldo surname: Lira-Junior fullname: Lira-Junior, Ronaldo organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil – sequence: 3 givenname: Eduardo Muniz Barretto surname: Tinoco fullname: Tinoco, Eduardo Muniz Barretto organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil – sequence: 4 givenname: Ricardo Guimarães surname: Fischer fullname: Fischer, Ricardo Guimarães email: Address: , ricfischer@globo.com organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25041550$$D View this record in MEDLINE/PubMed |
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Keywords | erythrocyte sedimentation rate cardiovascular disease C-reactive protein triglycerides periodontitis |
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(e_1_2_5_34_1) 1976; 34 e_1_2_5_15_1 e_1_2_5_38_1 e_1_2_5_14_1 e_1_2_5_39_1 e_1_2_5_17_1 e_1_2_5_36_1 e_1_2_5_9_1 e_1_2_5_16_1 e_1_2_5_37_1 e_1_2_5_8_1 e_1_2_5_11_1 e_1_2_5_7_1 e_1_2_5_10_1 e_1_2_5_35_1 e_1_2_5_6_1 e_1_2_5_13_1 e_1_2_5_32_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_33_1 e_1_2_5_4_1 e_1_2_5_3_1 e_1_2_5_2_1 e_1_2_5_19_1 e_1_2_5_18_1 e_1_2_5_30_1 e_1_2_5_31_1 |
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To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.
Material... To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. A total of 64... Aim To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material... To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.AIMTo determine... |
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SubjectTerms | Adult Biomarkers - blood Blood Sedimentation Body Mass Index C-reactive protein C-Reactive Protein - analysis Cardiovascular disease Cardiovascular Diseases - blood Cholesterol - blood Chronic Periodontitis - therapy Clinical trials Dental Plaque Index Dentistry Diabetes Complications Educational Status erythrocyte sedimentation rate Female Follow-Up Studies Gum disease Humans Hypertension - complications Male Middle Aged Periodontal Attachment Loss - classification Periodontal Attachment Loss - therapy Periodontal Debridement - methods Periodontal Index Periodontal Pocket - classification Periodontal Pocket - therapy periodontitis Risk Factors Smoking triglycerides Triglycerides - blood |
Title | The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial |
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