The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial

Aim To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical periodontology Vol. 41; no. 9; pp. 875 - 882
Main Authors Caúla, André Luis, Lira-Junior, Ronaldo, Tinoco, Eduardo Muniz Barretto, Fischer, Ricardo Guimarães
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.09.2014
Subjects
Online AccessGet full text
ISSN0303-6979
1600-051X
1600-051X
DOI10.1111/jcpe.12290

Cover

Abstract Aim To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). Results After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C‐reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). Conclusions The non‐surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.
AbstractList Aim To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). Results After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C‐reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). Conclusions The non‐surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.
To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.
To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.AIMTo determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).MATERIAL AND METHODSA total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group).After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).RESULTSAfter 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively).The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.CONCLUSIONSThe non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.
Aim To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). Results After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C-reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). Conclusions The non-surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis. [PUBLICATION ABSTRACT]
Author Caúla, André Luis
Lira-Junior, Ronaldo
Tinoco, Eduardo Muniz Barretto
Fischer, Ricardo Guimarães
Author_xml – sequence: 1
  givenname: André Luis
  surname: Caúla
  fullname: Caúla, André Luis
  organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
– sequence: 2
  givenname: Ronaldo
  surname: Lira-Junior
  fullname: Lira-Junior, Ronaldo
  organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
– sequence: 3
  givenname: Eduardo Muniz Barretto
  surname: Tinoco
  fullname: Tinoco, Eduardo Muniz Barretto
  organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
– sequence: 4
  givenname: Ricardo Guimarães
  surname: Fischer
  fullname: Fischer, Ricardo Guimarães
  email: Address: , ricfischer@globo.com
  organization: Department of Periodontology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25041550$$D View this record in MEDLINE/PubMed
BookMark eNp9kcFu1DAURS1URKeFDR-ALLFBSGnt2I4TdtWoU6gqikpR2Vke-1njaRIHOwGGr8fTabuoEN68zTlXfu8eoL0-9IDQa0qOaH7HazPAES3LhjxDM1oRUhBBv--hGWGEFVUjm310kNKaECoZYy_QfikIp0KQGYLrFWBwDsyIg8MDRB9s6Efd4nEFUQ8bHHpsdLQ-_NTJTK2OOPp0izsdbyGmD1jjquiyssJR9zZ0_g9YbFrfe7NNiV63L9Fzp9sEr-7nIfq2OL2efywuLs8-zU8uCiMYJYU1DeGVazgRprSiZtIxUXMOVlNXSm5qW9XOMsOt41y6UtMlk1pSIpYlA84O0btd7hDDjwnSqDqfDLSt7iFMSeWdecOaWlYZffsEXYcp9vl3W4o1jAgmMvXmnpqWHVg1RJ_33qiHA2bg_Q4wMaQUwT0ilKhtO2rbjrprJ8PkCWz8qEefjxe1b_-t0J3yy7ew-U-4Op9_OX1wip3j0wi_H53cl6okk0LdfD5Ti6vFDeH8Sn1lfwG1Yq_k
CitedBy_id crossref_primary_10_1186_s12903_024_04433_0
crossref_primary_10_1590_1807_3107bor_2021_vol35_0102
crossref_primary_10_1371_journal_pone_0181189
crossref_primary_10_14260_jemds_2019_855
crossref_primary_10_1016_j_ejim_2019_08_012
crossref_primary_10_31083_j_rcm2406159
crossref_primary_10_1111_prd_12249
crossref_primary_10_1590_pboci_2021_105
crossref_primary_10_3389_fcvm_2023_1255722
crossref_primary_10_1111_jcpe_13085
crossref_primary_10_1902_jop_2016_160279
crossref_primary_10_1038_s41598_019_52498_7
crossref_primary_10_1016_j_tcm_2023_03_003
crossref_primary_10_1016_j_prosdent_2015_10_003
crossref_primary_10_1016_j_colegn_2017_11_006
crossref_primary_10_1186_s12903_023_03143_3
crossref_primary_10_1111_jre_12328
crossref_primary_10_33393_dti_2023_2510
crossref_primary_10_1111_prd_12616
crossref_primary_10_1186_s12903_015_0026_6
crossref_primary_10_1111_prd_12379
crossref_primary_10_1111_hsc_12535
crossref_primary_10_1111_prd_12299
crossref_primary_10_1590_0103_6440201902124
crossref_primary_10_1002_14651858_CD009409_pub2
crossref_primary_10_3390_jcm13164722
crossref_primary_10_3389_fimmu_2024_1469077
crossref_primary_10_1902_jop_2015_140716
crossref_primary_10_3389_fcimb_2022_1056319
crossref_primary_10_1111_jcpe_12335
crossref_primary_10_1111_jcpe_12411
crossref_primary_10_4103_ccd_ccd_659_20
crossref_primary_10_1111_jcpe_13189
crossref_primary_10_1111_prd_12304
crossref_primary_10_3389_fphys_2020_609614
crossref_primary_10_1111_prd_12302
crossref_primary_10_1111_jcpe_13709
crossref_primary_10_3389_froh_2023_1324528
crossref_primary_10_3389_froh_2024_1364765
crossref_primary_10_1186_s12903_016_0272_2
crossref_primary_10_1111_jre_12340
crossref_primary_10_1111_odi_12625
crossref_primary_10_1111_cdoe_12414
crossref_primary_10_1111_jcpe_13554
crossref_primary_10_1051_medsci_2023193
crossref_primary_10_3389_fcvm_2020_625579
crossref_primary_10_1590_1807_3107bor_2020_vol34_0026
crossref_primary_10_1186_s12903_023_02781_x
crossref_primary_10_2334_josnusd_16_0173
crossref_primary_10_1177_0022034517701901
crossref_primary_10_1371_journal_pone_0230843
crossref_primary_10_1007_s40496_018_0165_3
crossref_primary_10_3109_10520295_2015_1082625
crossref_primary_10_3390_diagnostics11081376
crossref_primary_10_2147_JIR_S449661
crossref_primary_10_1155_2019_4128682
crossref_primary_10_31146_1682_8658_ecg_228_8_131_142
crossref_primary_10_7759_cureus_80086
Cites_doi 10.1177/154405910408300214
10.1053/euhj.2000.2148
10.1111/j.1600-051X.2005.00725.x
10.1111/j.1600-0765.2011.01380.x
10.1111/j.1600-051X.2007.01173.x
10.1016/j.ehj.2003.09.016
10.1161/01.CIR.98.8.731
10.1111/j.1600-051X.2009.01382.x
10.1034/j.1600-0757.2000.2230103.x
10.1111/j.1600-051X.2005.00689.x
10.1161/01.CIR.0000093381.57779.67
10.7326/0003-4819-150-7-200904070-00007
10.1016/j.ahj.2005.06.018
10.1053/euhj.1999.1699
10.1186/1471-2334-2-30
10.1111/jcpe.12110
10.1111/j.1600-051X.1981.tb02024.x
10.1034/j.1600-051x.2001.028010930.x
10.1111/j.1600-051X.2012.01942.x
10.1371/journal.pone.0077441
10.1177/154405910408300213
10.7326/0003-4819-151-7-200910060-00009
10.1177/154405910508400312
10.1093/ajcn/83.2.456S
10.1111/jcpe.12089
10.1097/SMJ.0b013e31802fa327
10.1056/NEJM196603312741302
10.1111/jcpe.12061
10.1034/j.1600-051X.2003.00282.x
10.1056/NEJM199901143400207
10.1902/jop.2009.080471
10.1161/CIRCULATIONAHA.106.637793
10.1097/SMJ.0b013e318038fa4d
10.1111/j.1600-0765.2004.00772.x
10.1902/jop.2003.74.7.1007
10.1902/jop.2000.72.9.1221
10.1902/jop.1999.70.12.1429
10.1111/jcpe.12171
10.1038/nature01323
10.1093/aje/kwg222
10.1111/j.1600-051X.1984.tb01309.x
10.1111/j.1600-051X.1987.tb01548.x
10.1902/jop.2007.060264
10.1902/jop.2000.71.10.1528
ContentType Journal Article
Copyright 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Copyright_xml – notice: 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
– notice: 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
– notice: Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
DBID BSCLL
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QP
K9.
7X8
DOI 10.1111/jcpe.12290
DatabaseName Istex
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Calcium & Calcified Tissue Abstracts
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Health & Medical Complete (Alumni)
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
ProQuest Health & Medical Complete (Alumni)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Dentistry
EISSN 1600-051X
EndPage 882
ExternalDocumentID 3406080371
25041550
10_1111_jcpe_12290
JCPE12290
ark_67375_WNG_FRFW044R_S
Genre article
Randomized Controlled Trial
Journal Article
Comparative Study
GroupedDBID ---
.3N
.GA
.Y3
05W
0R~
10A
1OB
1OC
29K
31~
33P
34H
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5RE
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A03
AAESR
AAEVG
AAHQN
AAIPD
AAMMB
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAWTL
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABEML
ABJNI
ABLJU
ABOCM
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCZN
ACGFO
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACRPL
ACSCC
ACXBN
ACXQS
ACYXJ
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZMN
AEFGJ
AEIGN
AEIMD
AENEX
AEUYR
AEYWJ
AFBPY
AFEBI
AFFNX
AFFPM
AFGKR
AFWVQ
AFZJQ
AGHNM
AGQPQ
AGXDD
AGYGG
AHBTC
AHEFC
AHMBA
AIACR
AIDQK
AIDYY
AIQQE
AITYG
AIURR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BSCLL
BY8
C45
CAG
COF
CS3
CWXXS
D-E
D-F
D-I
DC6
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBS
EJD
F00
F01
F04
F5P
FEDTE
FUBAC
FZ0
G-S
G.N
GODZA
H.T
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
IHE
IX1
J0M
K48
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MJL
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OVD
P2P
P2W
P2X
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
R.K
RIWAO
RJQFR
ROL
RX1
SAMSI
SUPJJ
TEORI
UB1
UMD
V8K
V9Y
W8V
W99
WBKPD
WBNRW
WIH
WIJ
WIK
WOHZO
WPGGZ
WQJ
WXSBR
XG1
YFH
YOC
YOJ
YUY
ZGI
ZXP
ZZTAW
~IA
~WT
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QP
K9.
7X8
ID FETCH-LOGICAL-c5310-dc9046f9405c2d5837f35844eda1f274c8d68fd3c4df447f2a1b37a7105b23e43
IEDL.DBID DR2
ISSN 0303-6979
1600-051X
IngestDate Thu Jul 10 23:43:03 EDT 2025
Fri Jul 25 12:29:13 EDT 2025
Mon Jul 21 06:04:17 EDT 2025
Thu Apr 24 23:02:56 EDT 2025
Wed Oct 01 02:21:23 EDT 2025
Fri Sep 19 01:20:06 EDT 2025
Sun Sep 21 06:15:03 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 9
Keywords erythrocyte sedimentation rate
cardiovascular disease
C-reactive protein
triglycerides
periodontitis
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5310-dc9046f9405c2d5837f35844eda1f274c8d68fd3c4df447f2a1b37a7105b23e43
Notes istex:D9092093053D3EA6B8A3BAD2A1F1AA013EE9E059
ark:/67375/WNG-FRFW044R-S
ArticleID:JCPE12290
No external funding, apart from the support of the authors' institution, was available for this study.
The authors declare that there are no conflicts of interest in this study.
Conflict of interest and sources of funding statement
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
ObjectType-Undefined-3
PMID 25041550
PQID 1553930535
PQPubID 105484
PageCount 8
ParticipantIDs proquest_miscellaneous_1554939876
proquest_journals_1553930535
pubmed_primary_25041550
crossref_primary_10_1111_jcpe_12290
crossref_citationtrail_10_1111_jcpe_12290
wiley_primary_10_1111_jcpe_12290_JCPE12290
istex_primary_ark_67375_WNG_FRFW044R_S
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate September 2014
PublicationDateYYYYMMDD 2014-09-01
PublicationDate_xml – month: 09
  year: 2014
  text: September 2014
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Malden
PublicationTitle Journal of clinical periodontology
PublicationTitleAlternate J Clin Periodontol
PublicationYear 2014
Publisher Blackwell Publishing Ltd
Publisher_xml – name: Blackwell Publishing Ltd
References Badersten, A., Nilveus, R. & Egelberg, J. (1987) Effect of nonsurgical periodontal therapy (VIII). Probing attachment changes related to clinical characteristics. Journal of Clinical Periodontology 14, 425-432.
Ide, M., McPartlin, D., Coward, P. Y., Crook, M., Lumb, P. & Wilson, R. F. (2003) Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. Journal of Clinical Periodontology 30, 334-340.
Loos, B. G., Craandijk, J., Hoek, F. J., vanWertheim- Dillen, P. M. & dervan Velden, U. (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of Periodontology 71, 1528-1534.
Noack, B., Genco, R. J., Trevisan, M., Grossi, S., Zambon, J. J. & De Nardin, E. (2001) Periodontal infections contribute to elevated systemic C-reactive protein level. Journal of Periodontology 72, 1221-1227.
Ross, R. (1999) Atherosclerosis - an inflammatory disease. New England Journal of Medicine 340, 115-126.
D'Aiuto, F., Orlandi, M. & Gunsolley, J. C. (2013) Evidence that periodontal treatment improves biomarkers and CVD outcomes. Journal of Clinical Periodontology 40 (Suppl. 14), S85-S105.
Joshipura, K. J., Wand, H. C., Merchant, A. T. & Rimm, E. B. (2004) Periodontal disease and biomarkers related to cardiovascular disease. Journal of Dental Research 83, 151-155.
Lösche, W., Marshal, G. J., Apatzidou, D. A., Krause, S., Kocher, T. & Kinane, D. F. (2005) Lipoprotein-associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease. Journal of Clinical Periodontology 32, 640-644.
Page, R. C. & Schroeder, H. E. (1976) Pathogenesis of inflammatory periodontal disease. A summary of current work. Laboratory Investigation 34, 235-249.
Ridker, P. M. (2003) C-reactive protein: a simple test to help predict risk of heart attack and stroke. Circulation 108, e81-e85.
Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E. A., Abbas, F., D'Aiuto, F., Kastelein, J. J. P. & Loos, B. G. (2014) Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. Journal of Clinical Periodontology 41, 70-79.
Willerson, J. T. & Ridker, P. M. (2004) Inflammation as a cardiovascular risk factor. Circulation 109 (Suppl. 1), II2-II10.
Buckley, D. I., Fu, R., Freeman, M., Rogers, K. & Helfand, M. (2009) C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force. Annals of Internal Medicine 151, 483-495.
Ebersole, J. L. & Cappelli, D. (2000) Acute-phase reactants in infections and inflammatory diseases. Periodontology 2000 23, 19-49.
Lösche, W. (2007) Periodontitis and cardiovascular disease: periodontal treatment lowers plasma cholesterol. Southern Medical Journal 100, 663-664.
Danesh, J., Collins, R., Peto, R. & Lowe, G. D. (2000) Haematocrit, viscosity, erythrocyte sedimentation rate: meta-analyses of prospective studies of coronary heart disease. European Heart Journal 21, 515-520.
D'Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D. & Tonetti, M. S. (2004) Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. Journal of Dental Research 83, 156-160.
Badersten, A., Nilveus, R. & Egelberg, J. (1981) Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. Journal of Clinical Periodontology 8, 57-72.
Yamazaki, K., Honda, T., Oda, T., Ueki-Maruyama, K., Nakajima, T., Yoshie, H. & Seymour, G. J. (2005) Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. Journal of Periodontal Research 40, 53-58.
Kamil, W., Al Habashneh, R., Khader, Y., Al Bayati, L. & Taani, D. (2011) Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis. Journal of Periodontal Research 46, 616-621.
D'Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J. & Tonetti, M. S. (2006) Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart Journal 151, 977-984.
Mattila, K., Vesanen, M., Valtonen, V., Nieminen, M., Palosuo, T., Rasi, V. & Asikainen, S. (2002) Effect of treating periodontitis on C-reactive protein levels: a pilot study. BMC Infectious Diseases 2, 30.
D'Aiuto, F., Nibali, L., Parkar, M., Suvan, J. & Tonetti, M. S. (2005) Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. Journal of Dental Research 84, 269-273.
Tonetti, M. S. & Van Dyke, T. E. (2013) Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of Clinical Periodontology 40 (Suppl. 14), S24-S29.
Vidal, F., Cordovil, I., Figueredo, C. M. S. & Fischer, R. G. (2013) Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. Journal of Clinical Periodontology 40, 681-687.
Ribeiro, J., Leão, A. & Novaes, A. B. (2005) Periodontal infection as a possible severity factor for rheumatoid arthritis. Journal of Clinical Periodontology 32, 412-416.
Erikssen, G., Liestøl, K., Bjørnholt, J. V., Stormorken, H., Thaulow, E. & Erikssen, J. (2000) Erythrocyte sedimentation rate: a possible marker of atherosclerosis and a strong predictor of coronary heart disease mortality. European Heart Journal 21, 1614-1620.
Hutter, J. W., Van der Velden, U., Varoufaki, A., Huffels, R. A. M., Hoek, F. J. & Loos, B. G. (2001) Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects. Journal of Clinical Periodontology 28, 930-936.
Bokhari, S. A. H., Khan, A. A., Butt, A. K., Azhar, M., Hanif, M., Izhar, M. & Tatakis, D. N. (2012) Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. Journal of Clinical Periodontology 39, 1065-1074.
Thomas, H. E. Jr, Kannel, W. B., Dawber, T. R. & McNamara, P. M. (1966) Cholesterol-phospholipid ratio in the prediction of coronary heart disease: the Framingham study. New England Journal of Medicine 274, 701-705.
Craig, R. G., Yip, J. K., So, M. K., Boylan, R. J., Socransky, S. S. & Haffajee, A. D. (2003) Relationship of destructive periodontal disease to the acute-phase response. Journal of Periodontology 74, 1007-1016.
Libby, P. (2006) Inflammation and cardiovascular disease mechanisms. American Journal of Clinical Nutrition 83, 456S-460S.
Cutler, C. W., Shinedling, E. A., Nunn, M., Jotwani, R., Kim, B. O., Nares, S. & Iacopino, A. M. (1999) Association between periodontitis and hyperlipidemia: cause or effect? Journal of Periodontology 70, 1429-1434.
Badersten, A., Nilveus, R. & Egelberg, J. (1984) Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. Journal of Clinical Periodontology 11, 63-76.
Ridker, P. M., Buring, J. E., Shih, J., Matias, M. & Hennekens, C. H. (1998) Prospective study of C- reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98, 731-733.
Paraskevas, S., Huizinga, J. D. & Loos, B. G. (2008) A systematic review and meta- analyses on C-reactive protein in relation to periodontitis. Journal of Clinical Periodontology 35, 277-290.
Libby, P. (2002) Inflammation in atherosclerosis. Nature 420, 868-874.
Behle, J. H., Sedaghatfar, M. H., Demmer, R. T., Wolf, D. L., Celenti, R., Kebschull, M., Belusko, P. B., Herrera-Abreu, M., Lalla, E. & Papapanou, P. N. (2009) Heterogeneity of systemic inflammatory responses to periodontal therapy. Journal of Clinical Periodontology 36, 287-294.
Oz, S. G., Fentoglu, O., Kilicarslan, A., Guven, G. S., Tanrtover, M. D., Aykac, Y. & Sozen, T. (2007) Beneficial effects of periodontal treatment on metabolic control of hypercholesterolemia. Southern Medical Journal 100, 686-691.
Sarwar, N., Danesh, J., Eiriksdottir, G., Sigurdsson, G., Wareham, N., Bingham, S., Boekholdt, S. M., Khaw, K. T. & Gudnason, V. (2007) Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 115, 450-458.
Andresdottir, M. B., Sigfusson, N., Sigvaldason, H. & Gudnason, V. (2003) Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study. American Journal of Epidemiology 158, 844-851.
Ip, S., Lichtenstein, A. H., Chung, M., Lau, J. & Balk, E. M. (2009) Systematic review: association of low-density lipoprotein subfractions with cardiovascular outcomes. Annals of Internal Medicine 150, 474-484.
Vidal, F., Figueredo, C. M., Cordovil, I. & Fischer, R. G. (2009) Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension. Journal of Periodontology 80, 786-791.
Buhlin, K., Gustafsson, A., Pockley, A. G., Frostegård, J. & Klinge, B. (2003) Risk factors for cardiovascular disease in patients with periodontitis. European Heart Journal 24, 2099-2107.
Demmer, R. T., Trinquart, L., Zuk, A., Fu, B. C., Blomkvist, J., Michalowicz, B. S., Ravaud, P. & Desvarieux, M. (2013) The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. PLoS One 8, e77441.
Page, R. C. & Eke, P. I. (2007) Case definitions for use in population-based surveillance of periodontitis. Journal of Periodontology 78 (Suppl. 7), 1387-1399.
1987; 14
2001; 72
1966; 274
2004; 83
2009; 80
2000; 23
2013; 40
2000; 21
2007; 100
2005; 84
1999; 340
2005; 40
2006; 151
2002; 2
1981; 8
2000; 71
2008; 35
2009; 150
2012; 39
2009; 151
2001; 28
2014; 41
2004; 109
2003; 158
2013; 8
2003; 74
2003; 30
2007; 78
2007; 115
2009; 36
2003; 108
2006; 83
1976; 34
1984; 11
2002; 420
2003; 24
2005; 32
2011; 46
1999; 70
1998; 98
e_1_2_5_27_1
e_1_2_5_28_1
e_1_2_5_25_1
Willerson J. T. (e_1_2_5_46_1) 2004; 109
e_1_2_5_26_1
e_1_2_5_47_1
e_1_2_5_23_1
e_1_2_5_24_1
e_1_2_5_45_1
e_1_2_5_21_1
e_1_2_5_44_1
e_1_2_5_22_1
e_1_2_5_43_1
e_1_2_5_29_1
e_1_2_5_42_1
e_1_2_5_20_1
e_1_2_5_41_1
e_1_2_5_40_1
Page R. C. (e_1_2_5_34_1) 1976; 34
e_1_2_5_15_1
e_1_2_5_38_1
e_1_2_5_14_1
e_1_2_5_39_1
e_1_2_5_17_1
e_1_2_5_36_1
e_1_2_5_9_1
e_1_2_5_16_1
e_1_2_5_37_1
e_1_2_5_8_1
e_1_2_5_11_1
e_1_2_5_7_1
e_1_2_5_10_1
e_1_2_5_35_1
e_1_2_5_6_1
e_1_2_5_13_1
e_1_2_5_32_1
e_1_2_5_5_1
e_1_2_5_12_1
e_1_2_5_33_1
e_1_2_5_4_1
e_1_2_5_3_1
e_1_2_5_2_1
e_1_2_5_19_1
e_1_2_5_18_1
e_1_2_5_30_1
e_1_2_5_31_1
References_xml – reference: Hutter, J. W., Van der Velden, U., Varoufaki, A., Huffels, R. A. M., Hoek, F. J. & Loos, B. G. (2001) Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects. Journal of Clinical Periodontology 28, 930-936.
– reference: Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E. A., Abbas, F., D'Aiuto, F., Kastelein, J. J. P. & Loos, B. G. (2014) Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. Journal of Clinical Periodontology 41, 70-79.
– reference: Page, R. C. & Eke, P. I. (2007) Case definitions for use in population-based surveillance of periodontitis. Journal of Periodontology 78 (Suppl. 7), 1387-1399.
– reference: Bokhari, S. A. H., Khan, A. A., Butt, A. K., Azhar, M., Hanif, M., Izhar, M. & Tatakis, D. N. (2012) Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. Journal of Clinical Periodontology 39, 1065-1074.
– reference: Kamil, W., Al Habashneh, R., Khader, Y., Al Bayati, L. & Taani, D. (2011) Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis. Journal of Periodontal Research 46, 616-621.
– reference: Paraskevas, S., Huizinga, J. D. & Loos, B. G. (2008) A systematic review and meta- analyses on C-reactive protein in relation to periodontitis. Journal of Clinical Periodontology 35, 277-290.
– reference: Sarwar, N., Danesh, J., Eiriksdottir, G., Sigurdsson, G., Wareham, N., Bingham, S., Boekholdt, S. M., Khaw, K. T. & Gudnason, V. (2007) Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 115, 450-458.
– reference: Craig, R. G., Yip, J. K., So, M. K., Boylan, R. J., Socransky, S. S. & Haffajee, A. D. (2003) Relationship of destructive periodontal disease to the acute-phase response. Journal of Periodontology 74, 1007-1016.
– reference: Cutler, C. W., Shinedling, E. A., Nunn, M., Jotwani, R., Kim, B. O., Nares, S. & Iacopino, A. M. (1999) Association between periodontitis and hyperlipidemia: cause or effect? Journal of Periodontology 70, 1429-1434.
– reference: Ide, M., McPartlin, D., Coward, P. Y., Crook, M., Lumb, P. & Wilson, R. F. (2003) Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. Journal of Clinical Periodontology 30, 334-340.
– reference: Libby, P. (2002) Inflammation in atherosclerosis. Nature 420, 868-874.
– reference: Ross, R. (1999) Atherosclerosis - an inflammatory disease. New England Journal of Medicine 340, 115-126.
– reference: D'Aiuto, F., Orlandi, M. & Gunsolley, J. C. (2013) Evidence that periodontal treatment improves biomarkers and CVD outcomes. Journal of Clinical Periodontology 40 (Suppl. 14), S85-S105.
– reference: Willerson, J. T. & Ridker, P. M. (2004) Inflammation as a cardiovascular risk factor. Circulation 109 (Suppl. 1), II2-II10.
– reference: Buhlin, K., Gustafsson, A., Pockley, A. G., Frostegård, J. & Klinge, B. (2003) Risk factors for cardiovascular disease in patients with periodontitis. European Heart Journal 24, 2099-2107.
– reference: Badersten, A., Nilveus, R. & Egelberg, J. (1987) Effect of nonsurgical periodontal therapy (VIII). Probing attachment changes related to clinical characteristics. Journal of Clinical Periodontology 14, 425-432.
– reference: Demmer, R. T., Trinquart, L., Zuk, A., Fu, B. C., Blomkvist, J., Michalowicz, B. S., Ravaud, P. & Desvarieux, M. (2013) The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. PLoS One 8, e77441.
– reference: Loos, B. G., Craandijk, J., Hoek, F. J., vanWertheim- Dillen, P. M. & dervan Velden, U. (2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of Periodontology 71, 1528-1534.
– reference: Behle, J. H., Sedaghatfar, M. H., Demmer, R. T., Wolf, D. L., Celenti, R., Kebschull, M., Belusko, P. B., Herrera-Abreu, M., Lalla, E. & Papapanou, P. N. (2009) Heterogeneity of systemic inflammatory responses to periodontal therapy. Journal of Clinical Periodontology 36, 287-294.
– reference: Vidal, F., Figueredo, C. M., Cordovil, I. & Fischer, R. G. (2009) Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension. Journal of Periodontology 80, 786-791.
– reference: Lösche, W. (2007) Periodontitis and cardiovascular disease: periodontal treatment lowers plasma cholesterol. Southern Medical Journal 100, 663-664.
– reference: Thomas, H. E. Jr, Kannel, W. B., Dawber, T. R. & McNamara, P. M. (1966) Cholesterol-phospholipid ratio in the prediction of coronary heart disease: the Framingham study. New England Journal of Medicine 274, 701-705.
– reference: D'Aiuto, F., Parkar, M., Andreou, G., Suvan, J., Brett, P. M., Ready, D. & Tonetti, M. S. (2004) Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers. Journal of Dental Research 83, 156-160.
– reference: Oz, S. G., Fentoglu, O., Kilicarslan, A., Guven, G. S., Tanrtover, M. D., Aykac, Y. & Sozen, T. (2007) Beneficial effects of periodontal treatment on metabolic control of hypercholesterolemia. Southern Medical Journal 100, 686-691.
– reference: Ridker, P. M., Buring, J. E., Shih, J., Matias, M. & Hennekens, C. H. (1998) Prospective study of C- reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98, 731-733.
– reference: Badersten, A., Nilveus, R. & Egelberg, J. (1984) Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. Journal of Clinical Periodontology 11, 63-76.
– reference: D'Aiuto, F., Nibali, L., Parkar, M., Suvan, J. & Tonetti, M. S. (2005) Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. Journal of Dental Research 84, 269-273.
– reference: D'Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J. & Tonetti, M. S. (2006) Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart Journal 151, 977-984.
– reference: Libby, P. (2006) Inflammation and cardiovascular disease mechanisms. American Journal of Clinical Nutrition 83, 456S-460S.
– reference: Ebersole, J. L. & Cappelli, D. (2000) Acute-phase reactants in infections and inflammatory diseases. Periodontology 2000 23, 19-49.
– reference: Lösche, W., Marshal, G. J., Apatzidou, D. A., Krause, S., Kocher, T. & Kinane, D. F. (2005) Lipoprotein-associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease. Journal of Clinical Periodontology 32, 640-644.
– reference: Ridker, P. M. (2003) C-reactive protein: a simple test to help predict risk of heart attack and stroke. Circulation 108, e81-e85.
– reference: Erikssen, G., Liestøl, K., Bjørnholt, J. V., Stormorken, H., Thaulow, E. & Erikssen, J. (2000) Erythrocyte sedimentation rate: a possible marker of atherosclerosis and a strong predictor of coronary heart disease mortality. European Heart Journal 21, 1614-1620.
– reference: Vidal, F., Cordovil, I., Figueredo, C. M. S. & Fischer, R. G. (2013) Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study. Journal of Clinical Periodontology 40, 681-687.
– reference: Noack, B., Genco, R. J., Trevisan, M., Grossi, S., Zambon, J. J. & De Nardin, E. (2001) Periodontal infections contribute to elevated systemic C-reactive protein level. Journal of Periodontology 72, 1221-1227.
– reference: Page, R. C. & Schroeder, H. E. (1976) Pathogenesis of inflammatory periodontal disease. A summary of current work. Laboratory Investigation 34, 235-249.
– reference: Joshipura, K. J., Wand, H. C., Merchant, A. T. & Rimm, E. B. (2004) Periodontal disease and biomarkers related to cardiovascular disease. Journal of Dental Research 83, 151-155.
– reference: Tonetti, M. S. & Van Dyke, T. E. (2013) Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of Clinical Periodontology 40 (Suppl. 14), S24-S29.
– reference: Buckley, D. I., Fu, R., Freeman, M., Rogers, K. & Helfand, M. (2009) C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force. Annals of Internal Medicine 151, 483-495.
– reference: Danesh, J., Collins, R., Peto, R. & Lowe, G. D. (2000) Haematocrit, viscosity, erythrocyte sedimentation rate: meta-analyses of prospective studies of coronary heart disease. European Heart Journal 21, 515-520.
– reference: Mattila, K., Vesanen, M., Valtonen, V., Nieminen, M., Palosuo, T., Rasi, V. & Asikainen, S. (2002) Effect of treating periodontitis on C-reactive protein levels: a pilot study. BMC Infectious Diseases 2, 30.
– reference: Yamazaki, K., Honda, T., Oda, T., Ueki-Maruyama, K., Nakajima, T., Yoshie, H. & Seymour, G. J. (2005) Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. Journal of Periodontal Research 40, 53-58.
– reference: Ip, S., Lichtenstein, A. H., Chung, M., Lau, J. & Balk, E. M. (2009) Systematic review: association of low-density lipoprotein subfractions with cardiovascular outcomes. Annals of Internal Medicine 150, 474-484.
– reference: Ribeiro, J., Leão, A. & Novaes, A. B. (2005) Periodontal infection as a possible severity factor for rheumatoid arthritis. Journal of Clinical Periodontology 32, 412-416.
– reference: Badersten, A., Nilveus, R. & Egelberg, J. (1981) Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. Journal of Clinical Periodontology 8, 57-72.
– reference: Andresdottir, M. B., Sigfusson, N., Sigvaldason, H. & Gudnason, V. (2003) Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study. American Journal of Epidemiology 158, 844-851.
– volume: 46
  start-page: 616
  year: 2011
  end-page: 621
  article-title: Effects of nonsurgical periodontal therapy on C‐reactive protein and serum lipids in Jordanian adults with advanced periodontitis
  publication-title: Journal of Periodontal Research
– volume: 40
  start-page: 681
  year: 2013
  end-page: 687
  article-title: Non‐surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study
  publication-title: Journal of Clinical Periodontology
– volume: 274
  start-page: 701
  year: 1966
  end-page: 705
  article-title: Cholesterol‐phospholipid ratio in the prediction of coronary heart disease: the Framingham study
  publication-title: New England Journal of Medicine
– volume: 80
  start-page: 786
  year: 2009
  end-page: 791
  article-title: Periodontal therapy reduces plasma levels of interleukin‐6, C‐reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension
  publication-title: Journal of Periodontology
– volume: 28
  start-page: 930
  year: 2001
  end-page: 936
  article-title: Lower numbers of erythrocytes and lower levels of hemoglobin in periodontitis patients compared to control subjects
  publication-title: Journal of Clinical Periodontology
– volume: 78
  start-page: 1387
  issue: Suppl. 7
  year: 2007
  end-page: 1399
  article-title: Case definitions for use in population‐based surveillance of periodontitis
  publication-title: Journal of Periodontology
– volume: 72
  start-page: 1221
  year: 2001
  end-page: 1227
  article-title: Periodontal infections contribute to elevated systemic C‐reactive protein level
  publication-title: Journal of Periodontology
– volume: 40
  start-page: S24
  issue: Suppl. 14
  year: 2013
  end-page: S29
  article-title: Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
  publication-title: Journal of Clinical Periodontology
– volume: 23
  start-page: 19
  year: 2000
  end-page: 49
  article-title: Acute‐phase reactants in infections and inflammatory diseases
  publication-title: Periodontology 2000
– volume: 83
  start-page: 456S
  year: 2006
  end-page: 460S
  article-title: Inflammation and cardiovascular disease mechanisms
  publication-title: American Journal of Clinical Nutrition
– volume: 158
  start-page: 844
  year: 2003
  end-page: 851
  article-title: Erythrocyte sedimentation rate, an independent predictor of coronary heart disease in men and women: The Reykjavik Study
  publication-title: American Journal of Epidemiology
– volume: 41
  start-page: 70
  year: 2014
  end-page: 79
  article-title: Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis
  publication-title: Journal of Clinical Periodontology
– volume: 83
  start-page: 156
  year: 2004
  end-page: 160
  article-title: Periodontitis and systemic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers
  publication-title: Journal of Dental Research
– volume: 98
  start-page: 731
  year: 1998
  end-page: 733
  article-title: Prospective study of C‐ reactive protein and the risk of future cardiovascular events among apparently healthy women
  publication-title: Circulation
– volume: 151
  start-page: 483
  year: 2009
  end-page: 495
  article-title: C‐reactive protein as a risk factor for coronary heart disease: a systematic review and meta‐analyses for the U.S. Preventive Services Task Force
  publication-title: Annals of Internal Medicine
– volume: 2
  start-page: 30
  year: 2002
  article-title: Effect of treating periodontitis on C‐reactive protein levels: a pilot study
  publication-title: BMC Infectious Diseases
– volume: 70
  start-page: 1429
  year: 1999
  end-page: 1434
  article-title: Association between periodontitis and hyperlipidemia: cause or effect?
  publication-title: Journal of Periodontology
– volume: 74
  start-page: 1007
  year: 2003
  end-page: 1016
  article-title: Relationship of destructive periodontal disease to the acute‐phase response
  publication-title: Journal of Periodontology
– volume: 14
  start-page: 425
  year: 1987
  end-page: 432
  article-title: Effect of nonsurgical periodontal therapy (VIII). Probing attachment changes related to clinical characteristics
  publication-title: Journal of Clinical Periodontology
– volume: 11
  start-page: 63
  year: 1984
  end-page: 76
  article-title: Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis
  publication-title: Journal of Clinical Periodontology
– volume: 420
  start-page: 868
  year: 2002
  end-page: 874
  article-title: Inflammation in atherosclerosis
  publication-title: Nature
– volume: 71
  start-page: 1528
  year: 2000
  end-page: 1534
  article-title: Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
  publication-title: Journal of Periodontology
– volume: 150
  start-page: 474
  year: 2009
  end-page: 484
  article-title: Systematic review: association of low‐density lipoprotein subfractions with cardiovascular outcomes
  publication-title: Annals of Internal Medicine
– volume: 115
  start-page: 450
  year: 2007
  end-page: 458
  article-title: Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies
  publication-title: Circulation
– volume: 24
  start-page: 2099
  year: 2003
  end-page: 2107
  article-title: Risk factors for cardiovascular disease in patients with periodontitis
  publication-title: European Heart Journal
– volume: 100
  start-page: 663
  year: 2007
  end-page: 664
  article-title: Periodontitis and cardiovascular disease: periodontal treatment lowers plasma cholesterol
  publication-title: Southern Medical Journal
– volume: 40
  start-page: S85
  issue: Suppl. 14
  year: 2013
  end-page: S105
  article-title: Evidence that periodontal treatment improves biomarkers and CVD outcomes
  publication-title: Journal of Clinical Periodontology
– volume: 36
  start-page: 287
  year: 2009
  end-page: 294
  article-title: Heterogeneity of systemic inflammatory responses to periodontal therapy
  publication-title: Journal of Clinical Periodontology
– volume: 30
  start-page: 334
  year: 2003
  end-page: 340
  article-title: Effect of treatment of chronic periodontitis on levels of serum markers of acute‐phase inflammatory and vascular responses
  publication-title: Journal of Clinical Periodontology
– volume: 109
  start-page: II2
  issue: Suppl. 1
  year: 2004
  end-page: II10
  article-title: Inflammation as a cardiovascular risk factor
  publication-title: Circulation
– volume: 8
  start-page: 57
  year: 1981
  end-page: 72
  article-title: Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis
  publication-title: Journal of Clinical Periodontology
– volume: 100
  start-page: 686
  year: 2007
  end-page: 691
  article-title: Beneficial effects of periodontal treatment on metabolic control of hypercholesterolemia
  publication-title: Southern Medical Journal
– volume: 21
  start-page: 515
  year: 2000
  end-page: 520
  article-title: Haematocrit, viscosity, erythrocyte sedimentation rate: meta‐analyses of prospective studies of coronary heart disease
  publication-title: European Heart Journal
– volume: 32
  start-page: 412
  year: 2005
  end-page: 416
  article-title: Periodontal infection as a possible severity factor for rheumatoid arthritis
  publication-title: Journal of Clinical Periodontology
– volume: 21
  start-page: 1614
  year: 2000
  end-page: 1620
  article-title: Erythrocyte sedimentation rate: a possible marker of atherosclerosis and a strong predictor of coronary heart disease mortality
  publication-title: European Heart Journal
– volume: 108
  start-page: e81
  year: 2003
  end-page: e85
  article-title: C‐reactive protein: a simple test to help predict risk of heart attack and stroke
  publication-title: Circulation
– volume: 8
  start-page: e77441
  year: 2013
  article-title: The influence of anti‐infective periodontal treatment on C‐reactive protein: a systematic review and meta‐analysis of randomized controlled trials
  publication-title: PLoS One
– volume: 340
  start-page: 115
  year: 1999
  end-page: 126
  article-title: Atherosclerosis – an inflammatory disease
  publication-title: New England Journal of Medicine
– volume: 84
  start-page: 269
  year: 2005
  end-page: 273
  article-title: Short‐term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol
  publication-title: Journal of Dental Research
– volume: 151
  start-page: 977
  year: 2006
  end-page: 984
  article-title: Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial
  publication-title: American Heart Journal
– volume: 32
  start-page: 640
  year: 2005
  end-page: 644
  article-title: Lipoprotein‐associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease
  publication-title: Journal of Clinical Periodontology
– volume: 39
  start-page: 1065
  year: 2012
  end-page: 1074
  article-title: Non‐surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial
  publication-title: Journal of Clinical Periodontology
– volume: 83
  start-page: 151
  year: 2004
  end-page: 155
  article-title: Periodontal disease and biomarkers related to cardiovascular disease
  publication-title: Journal of Dental Research
– volume: 40
  start-page: 53
  year: 2005
  end-page: 58
  article-title: Effect of periodontal treatment on the C‐reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients
  publication-title: Journal of Periodontal Research
– volume: 34
  start-page: 235
  year: 1976
  end-page: 249
  article-title: Pathogenesis of inflammatory periodontal disease. A summary of current work
  publication-title: Laboratory Investigation
– volume: 35
  start-page: 277
  year: 2008
  end-page: 290
  article-title: A systematic review and meta‐ analyses on C‐reactive protein in relation to periodontitis
  publication-title: Journal of Clinical Periodontology
– ident: e_1_2_5_14_1
  doi: 10.1177/154405910408300214
– ident: e_1_2_5_19_1
  doi: 10.1053/euhj.2000.2148
– ident: e_1_2_5_29_1
  doi: 10.1111/j.1600-051X.2005.00725.x
– ident: e_1_2_5_24_1
  doi: 10.1111/j.1600-0765.2011.01380.x
– ident: e_1_2_5_35_1
  doi: 10.1111/j.1600-051X.2007.01173.x
– ident: e_1_2_5_9_1
  doi: 10.1016/j.ehj.2003.09.016
– ident: e_1_2_5_38_1
  doi: 10.1161/01.CIR.98.8.731
– ident: e_1_2_5_6_1
  doi: 10.1111/j.1600-051X.2009.01382.x
– ident: e_1_2_5_18_1
  doi: 10.1034/j.1600-0757.2000.2230103.x
– ident: e_1_2_5_36_1
  doi: 10.1111/j.1600-051X.2005.00689.x
– ident: e_1_2_5_37_1
  doi: 10.1161/01.CIR.0000093381.57779.67
– ident: e_1_2_5_22_1
  doi: 10.7326/0003-4819-150-7-200904070-00007
– ident: e_1_2_5_15_1
  doi: 10.1016/j.ahj.2005.06.018
– ident: e_1_2_5_16_1
  doi: 10.1053/euhj.1999.1699
– ident: e_1_2_5_30_1
  doi: 10.1186/1471-2334-2-30
– ident: e_1_2_5_44_1
  doi: 10.1111/jcpe.12110
– ident: e_1_2_5_3_1
  doi: 10.1111/j.1600-051X.1981.tb02024.x
– ident: e_1_2_5_20_1
  doi: 10.1034/j.1600-051x.2001.028010930.x
– ident: e_1_2_5_7_1
  doi: 10.1111/j.1600-051X.2012.01942.x
– ident: e_1_2_5_17_1
  doi: 10.1371/journal.pone.0077441
– ident: e_1_2_5_23_1
  doi: 10.1177/154405910408300213
– ident: e_1_2_5_8_1
  doi: 10.7326/0003-4819-151-7-200910060-00009
– ident: e_1_2_5_12_1
  doi: 10.1177/154405910508400312
– volume: 34
  start-page: 235
  year: 1976
  ident: e_1_2_5_34_1
  article-title: Pathogenesis of inflammatory periodontal disease. A summary of current work
  publication-title: Laboratory Investigation
– ident: e_1_2_5_26_1
  doi: 10.1093/ajcn/83.2.456S
– ident: e_1_2_5_43_1
  doi: 10.1111/jcpe.12089
– ident: e_1_2_5_32_1
  doi: 10.1097/SMJ.0b013e31802fa327
– ident: e_1_2_5_42_1
  doi: 10.1056/NEJM196603312741302
– volume: 109
  start-page: II2
  issue: 1
  year: 2004
  ident: e_1_2_5_46_1
  article-title: Inflammation as a cardiovascular risk factor
  publication-title: Circulation
– ident: e_1_2_5_13_1
  doi: 10.1111/jcpe.12061
– ident: e_1_2_5_21_1
  doi: 10.1034/j.1600-051X.2003.00282.x
– ident: e_1_2_5_39_1
  doi: 10.1056/NEJM199901143400207
– ident: e_1_2_5_45_1
  doi: 10.1902/jop.2009.080471
– ident: e_1_2_5_40_1
  doi: 10.1161/CIRCULATIONAHA.106.637793
– ident: e_1_2_5_28_1
  doi: 10.1097/SMJ.0b013e318038fa4d
– ident: e_1_2_5_47_1
  doi: 10.1111/j.1600-0765.2004.00772.x
– ident: e_1_2_5_10_1
  doi: 10.1902/jop.2003.74.7.1007
– ident: e_1_2_5_31_1
  doi: 10.1902/jop.2000.72.9.1221
– ident: e_1_2_5_11_1
  doi: 10.1902/jop.1999.70.12.1429
– ident: e_1_2_5_41_1
  doi: 10.1111/jcpe.12171
– ident: e_1_2_5_25_1
  doi: 10.1038/nature01323
– ident: e_1_2_5_2_1
  doi: 10.1093/aje/kwg222
– ident: e_1_2_5_4_1
  doi: 10.1111/j.1600-051X.1984.tb01309.x
– ident: e_1_2_5_5_1
  doi: 10.1111/j.1600-051X.1987.tb01548.x
– ident: e_1_2_5_33_1
  doi: 10.1902/jop.2007.060264
– ident: e_1_2_5_27_1
  doi: 10.1902/jop.2000.71.10.1528
SSID ssj0017333
Score 2.3666973
Snippet Aim To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material...
To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. A total of 64...
Aim To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material...
To determine the influence of non-surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease.AIMTo determine...
SourceID proquest
pubmed
crossref
wiley
istex
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 875
SubjectTerms Adult
Biomarkers - blood
Blood Sedimentation
Body Mass Index
C-reactive protein
C-Reactive Protein - analysis
Cardiovascular disease
Cardiovascular Diseases - blood
Cholesterol - blood
Chronic Periodontitis - therapy
Clinical trials
Dental Plaque Index
Dentistry
Diabetes Complications
Educational Status
erythrocyte sedimentation rate
Female
Follow-Up Studies
Gum disease
Humans
Hypertension - complications
Male
Middle Aged
Periodontal Attachment Loss - classification
Periodontal Attachment Loss - therapy
Periodontal Debridement - methods
Periodontal Index
Periodontal Pocket - classification
Periodontal Pocket - therapy
periodontitis
Risk Factors
Smoking
triglycerides
Triglycerides - blood
Title The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial
URI https://api.istex.fr/ark:/67375/WNG-FRFW044R-S/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcpe.12290
https://www.ncbi.nlm.nih.gov/pubmed/25041550
https://www.proquest.com/docview/1553930535
https://www.proquest.com/docview/1554939876
Volume 41
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVWIB
  databaseName: Wiley Online Library - Core collection (SURFmarket)
  issn: 0303-6979
  databaseCode: DR2
  dateStart: 19970101
  customDbUrl:
  isFulltext: true
  eissn: 1600-051X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017333
  providerName: Wiley-Blackwell
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFD6U-qAv3rVpq4wogkKWTeaSHfFFatdSsMhqaV8kzFVFm5TuLmif_An-Rn-JZ2aS4EoR9C2QEzKZOWfmO5lvvgPwyJcG3QRnP2W0yBl3Ipe2FLnirJB-LIyM6vyvD8TeIds_5sdr8Lw_C5P0IYYfbiEy4nwdAlzp-e9Bbk7dqAhy5TgBF5THPdrZoB1VVDTVkcc5Oheykp02aaTxDI-urEaXQsd-vQhqriLXuPRMr8H7vtGJcfJ5tFzokTn_Q8_xf7_qOlztMCl5kZzoBqy55iZcfhl4RKEU3C34gM5EEvODtJ4EcWTMZsM5SpLOb30jbUPMCrWVBNI6OQnsn7P5M6KI-Pn9B_r84iPB5dG2J5_OnSX9wUwSq4fchsPp7rudvbyr0JAbjN1xbo3E_NpLRH2mtByTXU8R0TBnVeEx3zUTKybeUsOsZ6zypSo0rRSiGq5L6hi9A-tN27gNIGU50d5RbQV3zCHk50VluNalEcpxozJ40o9UbTr58lBF40s9pDHYdXXsugweDranSbTjQqvHccAHE-yRQHOreH108KqezqZHY8Zm9dsMtnuPqLsIn9eh3pKkQR0ngwfDbYzNsOGiGtcuow2TVOKCk8Hd5EnDy4J0XEgPM3ga_eEvDa33d97sxqvNfzHegiuI7lgixG3D-uJs6e4hglro-zFSfgEAjRbk
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB1BeygXvimBAkYgJJCy2iS2s-aG2i5LaVdoadXerMQfLYImVXdXgp74CfxGfgkzTjZiUYUEt0iZKIk9Y7-xn98APPepQTfB0a8wpYy5cDJWNpVxIXiifF8aFdT598ZydMB3jsRRy82hszCNPkS34EaREcZrCnBakP49ys2Z6yWkV34VVmmDjuJya9KpRyV51lSSx1E6lipXrTppIPJ0zy7NR6vUtF8vA5vL2DVMPsMbTYXVadAsJM7J5958VvbMxR-Kjv_9XzfhegtL2ZvGj27BFVfdhrUtohJRNbg7cIz-xBryB6s9I31kTGjpKCVrjnB9Y3XFzBK7lRFvnZ0SAeh8-poVTP78_gPdfnbCcIa09emnC2fZ4mwmCwVE7sLBcHt_cxS3RRpig-Hbj61RmGJ7hcDPpFZgvuszBDXc2SLxmPKagZUDbzPDrec892mRlFleILARZZo5nt2Dlaqu3H1gaToovctKK4XjDlG_SHIjyjI1snDCFBG8XHSVNq2CORXS-KK7TAabToemi-BZZ3vW6HZcavUi9Hhngi1CTLdc6MPxWz2cDA_7nE_0xwg2Fi6h2yCfaiq5pDISyIngaXcbw5P2XIrK1fNgw1WmcM6JYL1xpe5lpB5HGWIEr4JD_OVD9c7mh-1w9eBfjJ_A2mh_b1fvvhu_fwjXEOzxhh-3ASuz87l7hIBqVj4OYfMLWdcbAA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFD7UFtQX75dorSOKoJBlk8xMdsQXaRtr1aWslvZFhsxNS22ytLugffIn-Bv9JZ6ZXOhKEfQtkBOSnDln5jvJN98BeOJSjWGCs1-pFY8pszwWJuVxyWgi3JBrEdT534_51i7d3mf7S_Cy2wvT6EP0H9x8ZoT52if41LizSa6ndpB4ufILsEI5llceEk168agkz5pG8jhJx1zkohUnDTye_tqF5WjFe_bbeVhzEbqGtae4Cp-6p24oJ4eD-UwN9Okfgo7_-1rX4EoLSsmrJoquw5KtbsClDU8k8r3gbsJnjCbSUD9I7YhXR8Zy1m-kJM0Gru-krohe4LYSz1onR57-c3zygpSE__rxE4N-9oXg-mjqo4NTa0i3M5OE9iG3YLfY_Li-FbctGmKNyTuMjRZYYDuBsE-nhmG16zKENNSaMnFY8OqR4SNnMk2NozR3aZmoLC8R1jCVZpZmt2G5qit7F0iajpSzmTKcWWoR87Mk10ypVPPSMl1G8KwbKalb_XLfRuOr7OsYdJ0MrovgcW87bVQ7zrV6Gga8N0GPeJ5bzuTe-LUsJsXekNKJ_BDBahcRsk3xE-kbLonMy-NE8Kg_jcnp_7iUla3nwYaKTOCKE8GdJpL6m3ntOF8fRvA8xMNfHlRur-9shqN7_2L8EC7ubBTy3Zvx2_twGZEebchxq7A8O57bB4imZmotJM1v-bwZrw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+periodontal+therapy+on+cardiovascular+risk+markers%3A+a+6%E2%80%90month+randomized+clinical+trial&rft.jtitle=Journal+of+clinical+periodontology&rft.au=Ca%C3%BAla%2C+Andr%C3%A9+Luis&rft.au=Lira%E2%80%90Junior%2C+Ronaldo&rft.au=Tinoco%2C+Eduardo+Muniz+Barretto&rft.au=Fischer%2C+Ricardo+Guimar%C3%A3es&rft.date=2014-09-01&rft.issn=0303-6979&rft.eissn=1600-051X&rft.volume=41&rft.issue=9&rft.spage=875&rft.epage=882&rft_id=info:doi/10.1111%2Fjcpe.12290&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_jcpe_12290
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0303-6979&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0303-6979&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0303-6979&client=summon