The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial

• Published in: Journal of clinical periodontology Vol. 41; no. 9; pp. 875 - 882
• Main Authors: Caúla, André Luis, Lira-Junior, Ronaldo, Tinoco, Eduardo Muniz Barretto, Fischer, Ricardo Guimarães
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.09.2014
• Subjects: Adult; Biomarkers - blood; Blood Sedimentation; Body Mass Index; C-reactive protein; C-Reactive Protein - analysis; Cardiovascular disease; Cardiovascular Diseases - blood; Cholesterol - blood; Chronic Periodontitis - therapy; Clinical trials; Dental Plaque Index; Dentistry; Diabetes Complications; Educational Status; erythrocyte sedimentation rate; Female; Follow-Up Studies; Gum disease; Humans; Hypertension - complications; Male; Middle Aged; Periodontal Attachment Loss - classification; Periodontal Attachment Loss - therapy; Periodontal Debridement - methods; Periodontal Index; Periodontal Pocket - classification; Periodontal Pocket - therapy; periodontitis; Risk Factors; Smoking; triglycerides; Triglycerides - blood; erythrocyte sedimentation rate; cardiovascular disease; C-reactive protein; triglycerides; periodontitis
• ISSN: 0303-6979; 1600-051X; 1600-051X
• DOI: 10.1111/jcpe.12290

Aim To determine the influence of non‐surgical mechanical periodontal treatment on inflammatory markers related to risk for cardiovascular disease. Material and Methods A total of 64 patients with severe chronic periodontitis was randomly subjected to immediately periodontal treatment (test group, n = 32) or delayed periodontal treatment, without treatment during the study period (control group, n = 32). Clinical periodontal and laboratory examinations were performed at baseline (T0), 2 months (T2), and 6 months (T6) after the initial examinations (Control group) or completion of periodontal treatment (Test group). Results After 2 months of periodontal treatment there was a significant reduction of erythrocyte sedimentation rate (ESR) and triglycerides (p = 0.002, p = 0.004, respectively) in the test group. Median values of C‐reactive protein, ESR, total cholesterol, and triglycerides were reduced after 6 month of periodontal treatment in the test group (p < 0.001, p < 0.001, p < 0.001, and p = 0.015, respectively). Conclusions The non‐surgical periodontal treatment was effective in reducing the levels of systemic inflammation markers and improved the lipid profile in subjects with severe chronic periodontitis.