Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss...

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Published inGenes & diseases Vol. 6; no. 1; pp. 6 - 15
Main Authors He, Rong-Zhang, Luo, Di-Xian, Mo, Yin-Yuan
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.03.2019
Chongqing Medical University
KeAi Communications Co., Ltd
Subjects
Alternative splicing
LncRNA
Posttranscriptional regulation
Protein stability
RNA binding proteins
RNA stability
LncRNA
Alternative splicing
RNA stability
Protein stability
Posttranscriptional regulation
RNA binding proteins
Online AccessGet full text
ISSN2352-3042
2352-4820
2352-3042
DOI10.1016/j.gendis.2019.01.003

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Summary:Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2019.01.003