Hepcidin in the diagnosis of iron disorders

The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmoniz...

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Published inBlood Vol. 127; no. 23; pp. 2809 - 2813
Main Authors Girelli, Domenico, Nemeth, Elizabeta, Swinkels, Dorine W.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.06.2016
American Society of Hematology
Subjects
Animals
Biomarkers - blood
Blood Chemical Analysis - methods
Diagnostic Techniques and Procedures
Hematologic Tests
Hepcidins - blood
Hepcidins - chemistry
Hepcidins - physiology
Humans
Iron Metabolism Disorders - blood
Iron Metabolism Disorders - diagnosis
Iron Metabolism Disorders - therapy
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ISSN0006-4971
1528-0020
1528-0020
DOI10.1182/blood-2015-12-639112

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Summary:The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.
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ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood-2015-12-639112