Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients
Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible associatio...
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| Published in | International journal of genomics Vol. 2014; no. 2014; pp. 1 - 5 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2014
John Wiley & Sons, Inc Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2314-436X 2314-4378 |
| DOI | 10.1155/2014/920491 |
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| Abstract | Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population. |
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| AbstractList | Background.
Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli
Mycobacterium leprae
; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the
IL-17A G-197A
(rs227593) and
IL-17F A7488G
(His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population.
Methods.
Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique.
Results.
We found nonsignificant differences in genotype and allele frequencies related to
IL-17A G-197A
(rs227593) and
IL-17F A7488G
(His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals.
Conclusions.
Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of
IL-17A G-197A
(rs227593) and
IL-17F A7488G
(His161Arg, rs763780), suggesting that
IL-17
polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population. Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population. |
| Author | Ramos-Payán, Rosalío Escamilla-Tilch, Mónica Pérez-Lucas, Riky Luis Torres-Carrillo, Nora Magdalena Pérez-Suárez, Thalía Gabriela Estrada-Parra, Sergio Estrada-Garcia, Iris Arenas, R. Granados, Julio Salazar, Ma. Isabel |
| AuthorAffiliation | 2 Instituto Nacional de Geriatría, Periférico Sur No. 2767, Col. San Jerónimo Lídice, Del. Magdalena Contreras, 10200 México, DF, Mexico 5 Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010 Culiacán, SIN, Mexico 4 Sección de Micología, Hospital General Dr. Manuel Gea González, 14080 México, DF, Mexico 3 Departamento de Trasplantes, División de Inmunogenética, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14000 México, DF, Mexico 1 Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, Mexico |
| AuthorAffiliation_xml | – name: 4 Sección de Micología, Hospital General Dr. Manuel Gea González, 14080 México, DF, Mexico – name: 1 Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 México, DF, Mexico – name: 3 Departamento de Trasplantes, División de Inmunogenética, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14000 México, DF, Mexico – name: 2 Instituto Nacional de Geriatría, Periférico Sur No. 2767, Col. San Jerónimo Lídice, Del. Magdalena Contreras, 10200 México, DF, Mexico – name: 5 Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010 Culiacán, SIN, Mexico |
| Author_xml | – sequence: 1 fullname: Torres-Carrillo, Nora Magdalena – sequence: 2 fullname: Estrada-Parra, Sergio – sequence: 3 fullname: Salazar, Ma. Isabel – sequence: 4 fullname: Pérez-Suárez, Thalía Gabriela – sequence: 5 fullname: Ramos-Payán, Rosalío – sequence: 6 fullname: Arenas, R. – sequence: 7 fullname: Granados, Julio – sequence: 8 fullname: Estrada-Garcia, Iris – sequence: 9 fullname: Escamilla-Tilch, Mónica – sequence: 10 fullname: Pérez-Lucas, Riky Luis |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25431761$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_jmv_27127 crossref_primary_10_3389_fimmu_2018_02920 crossref_primary_10_1111_ahg_12291 crossref_primary_10_1016_j_abd_2021_09_016 |
| Cites_doi | 10.1007/s00335-010-9287-1 10.1016/j.gene.2013.09.113 10.1093/nar/16.3.1215 10.1016/j.humimm.2009.04.030 10.1080/00365520902795430 10.1016/j.fsigen.2008.07.006 10.1111/iji.12097 10.1002/ibd.20339 10.1016/j.coi.2007.07.020 10.1002/ijc.25027 10.1128/CMR.00048-08 10.1016/j.gene.2012.11.017 10.3892/br.2013.167 10.3748/wjg.v19.i34.5693 10.1111/1523-1747.ep12381958 10.3410/M2-30 10.1136/ard.2005.045922 10.47276/lr.83.2.184 10.1002/ajpa.20765 10.1016/S0140-6736(98)06322-3 |
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| Copyright | Copyright © 2014 Mónica Escamilla-Tilch et al. Copyright © 2014 Monica Escamilla-Tilch et al. Monica Escamilla-Tilch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2014 Mónica Escamilla-Tilch et al. 2014 |
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| Snippet | Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic... Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae ; it has been determined that genetic... Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae ; it has been determined that genetic... |
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| SubjectTerms | Disease Gastric cancer Genes Genotype & phenotype Hospitals Infections Leprosy Mycobacterium leprae Population |
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| Title | Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients |
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