Lack of Association of the Polymorphisms IL-17A (−197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients

Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible associatio...

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Published inInternational journal of genomics Vol. 2014; no. 2014; pp. 1 - 5
Main Authors Torres-Carrillo, Nora Magdalena, Estrada-Parra, Sergio, Salazar, Ma. Isabel, Pérez-Suárez, Thalía Gabriela, Ramos-Payán, Rosalío, Arenas, R., Granados, Julio, Estrada-Garcia, Iris, Escamilla-Tilch, Mónica, Pérez-Lucas, Riky Luis
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2014
John Wiley & Sons, Inc
Wiley
Subjects
Disease
Gastric cancer
Genes
Genotype & phenotype
Hospitals
Infections
Leprosy
Mycobacterium leprae
Population
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ISSN2314-436X
2314-4378
DOI10.1155/2014/920491

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Summary:Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results. We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.
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Academic Editor: Elena Pasyukova
ISSN:2314-436X
2314-4378
DOI:10.1155/2014/920491