Associations of the lipid genetic variants Thr54 (FABP2) and -493T (MTTP) with total cholesterol and low-density lipoprotein cholesterol levels in Mexican subjects

• Published in: Journal of international medical research Vol. 46; no. 4; pp. 1467 - 1476
• Main Authors: Gonzalez-Becerra, Karina, Ramos-Lopez, Omar, Garcia-Cazarin, Mary Lolis, Barron-Cabrera, Elisa, Panduro, Arturo, Martinez-Lopez, Erika
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2018; Sage Publications Ltd; SAGE Publishing
• Subjects: Adult; Cholesterol; Cholesterol - metabolism; Clinical Reports; Demography; Fatty Acid-Binding Proteins - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Health risk assessment; Humans; Lipoproteins; Lipoproteins, LDL - metabolism; Male; Metabolic Diseases - genetics; Mexico; Polymorphism, Single Nucleotide - genetics; Racial Groups - genetics; Risk Factors; Mexico; FABP2; Mexico; Lipid genetic variants; polymorphism; hypercholesterolaemia; MTTP
• ISSN: 0300-0605; 1473-2300; 1473-2300
• DOI: 10.1177/0300060517748518

Objective Mexico has one of the world’s highest rates of obesity, which is influenced by lipid-genetic and lifestyle factors. This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects. Methods A total of 523 subjects participated in a cross-sectional study. Genotyping for FABP2 and MTTP was performed using real-time RT-PCR. Biochemical and anthropometric data were evaluated. Results The genetically at-risk group (Thr54/-493T) was associated with significantly higher total and low-density lipoprotein cholesterol levels (difference between genetically at-risk group and wild-type group: 10.6 mg/dL and 8.94 mg/dL, respectively). Carriers within the genetically at-risk group had a significantly higher prevalence rate of hypercholesterolaemia (42.5% vs. 32.0%) and higher LDL-C levels (37.6% vs. 26.4%) than did non-carriers. Conclusions Subjects who are genetically at risk (Thr54/-493T) have higher total cholesterol levels, low-density lipoprotein cholesterol levels, and prevalence rate of hypercholesterolaemia. These findings highlight the importance of basing nutritional intervention strategies for preventing and treating chronic diseases on individual genetic characteristics.