Ethanol lavage of huge hepatic cysts by using EUS guidance and a percutaneous approach

• Published in: Gastrointestinal endoscopy Vol. 80; no. 6; pp. 1014 - 1021
• Main Authors: Lee, Seohyun, Seo, Dong-Wan, Paik, Woo Hyun, Park, Do Hyun, Lee, Sang Soo, Lee, Sung Koo, Kim, Myung-Hwan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Ablation Techniques; Aged; Cohort Studies; Cysts - therapy; Drainage; Endosonography; Ethanol - therapeutic use; Female; Gastroenterology and Hepatology; Humans; Liver - surgery; Liver Diseases - therapy; Male; Middle Aged; Retrospective Studies; Solvents - therapeutic use; Therapeutic Irrigation - methods; Treatment Outcome; Ultrasonography, Interventional; PCD; IQR; CA; CEA; carcinoembryonic antigen; percutaneous catheter drainage; interquartile range; carbohydrate antigen
• ISSN: 0016-5107; 1097-6779; 1097-6779
• DOI: 10.1016/j.gie.2014.03.037

EUS-guided and percutaneous lavage therapy for large hepatic cysts can replace surgical drainage. EUS-guided therapy can especially enable the alcohol lavage to be done with a 1-step approach. To evaluate the utility of EUS-guidance and percutaneous ethanol lavage therapy. Retrospective cohort study. Tertiary-care referral teaching hospital. Adult patients with large liver cysts who underwent cyst drainage and alcohol ablation between 2009 and 2012. Ethanol lavage via percutaneous and/or EUS-guided approaches. Feasibility, efficacy, and safety of ethanol lavage. Seventeen patients with 19 hepatic cysts were enrolled. The median cyst volume before therapy was 368.9 mL (interquartile range, 195.3-795.9 mL). Ten cysts were drained by the percutaneous approach with a pigtail catheter, and 8 cysts underwent EUS-guided aspiration and lavage treatment. In 1 case, both the percutaneous approach and EUS-guided puncture were used. During the median 11.5-month follow-up of the percutaneous approach group, the cysts showed 97.5% reduction. During the median 15-month follow-up of the EUS-guided group, the cysts showed nearly 100% reduction. Percutaneous catheter drainage ethanol lavage was more feasible for right-sided larger cysts, whereas the EUS-guided approach was useful for left-sided lobe cysts. Single-center retrospective study. Excellent symptomatic and radiologic responses and long-term results were achieved with percutaneous catheter–guided and EUS-guided ethanol lavage. Ethanol lavage could be considered a primary method of treatment for hepatic cysts given its high degree of technical feasibility and safety.