A neural algorithm for Drosophila linear and nonlinear decision-making

• Published in: Scientific reports Vol. 10; no. 1; p. 18660
• Main Authors: Zhao, Feifei, Zeng, Yi, Guo, Aike, Su, Haifeng, Xu, Bo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.10.2020; Nature Publishing Group
• Subjects: 631/378/116; 639/166; Action Potentials; Algorithms; Animals; Computational neuroscience; Decision Making; Dopamine receptors; Drosophila; Drosophila - physiology; Firing pattern; gamma-Aminobutyric Acid - metabolism; Gating; Humanities and Social Sciences; Insects; Learning; Mental task performance; Models, Neurological; multidisciplinary; Neural networks; Reversal learning; Science; Science (multidisciplinary); Visual discrimination learning; γ-Aminobutyric acid
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-75628-y

It has been evidenced that vision-based decision-making in Drosophila consists of both simple perceptual (linear) decision and value-based (non-linear) decision. This paper proposes a general computational spiking neural network (SNN) model to explore how different brain areas are connected contributing to Drosophila linear and nonlinear decision-making behavior. First, our SNN model could successfully describe all the experimental findings in fly visual reinforcement learning and action selection among multiple conflicting choices as well. Second, our computational modeling shows that dopaminergic neuron-GABAergic neuron-mushroom body (DA-GABA-MB) works in a recurrent loop providing a key circuit for gain and gating mechanism of nonlinear decision making. Compared with existing models, our model shows more biologically plausible on the network design and working mechanism, and could amplify the small differences between two conflicting cues more clearly. Finally, based on the proposed model, the UAV could quickly learn to make clear-cut decisions among multiple visual choices and flexible reversal learning resembling to real fly. Compared with linear and uniform decision-making methods, the DA-GABA-MB mechanism helps UAV complete the decision-making task with fewer steps.