Progression of lymphatic filariasis antigenaemia and microfilaraemia over 4.5 years in antigen-positive individuals, Samoa 2019-2023

• Published in: International journal of infectious diseases Vol. 155; pp. 107891 - None
• Main Authors: Mayfield, Helen J., Sartorius, Benn, Muttucumaru, Ramona, Sheridan, Sarah, Howlett, Maddison, Martin, Beatris Mario, Hedtke, Shannon M., Field, Emma, Thomsen, Robert, Viali, Satupaitea, Graves, Patricia M., Lau, Colleen L.
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.06.2025; Elsevier
• Subjects: Adolescent; Adult; Aged; Animals; Antigens, Helminth - blood; Child; Clustering; Disease Progression; Elephantiasis, Filarial - drug therapy; Elephantiasis, Filarial - epidemiology; Elephantiasis, Filarial - immunology; Elephantiasis, Filarial - parasitology; Female; Filaricides - therapeutic use; Humans; Male; Mass Drug Administration; Microfilariae - immunology; Middle Aged; Neglected Tropical Disease elimination; Pacific Islands; Prevalence; Recrudescence; Samoa - epidemiology; Wuchereria bancrofti; Wuchereria bancrofti - immunology; Young Adult; Samoa; Recrudescence; Wuchereria bancrofti; Neglected Tropical Disease elimination; Clustering; Pacific Islands
• ISSN: 1201-9712; 1878-3511; 1878-3511
• DOI: 10.1016/j.ijid.2025.107891

•Persistent microfilaraemia in Samoa 4.5-years post-mass drug administration (MDA).•Single round of triple-drug MDA was not sufficient for sustained clearance of Mf.•Higher antigen (Ag) prevalence in household members of Mf-positive people.•Household members of Ag/Mf-positive people should be tested and treated. The first round of triple-drug mass drug administration (MDA) for lymphatic filariasis (LF) in Samoa was in 2018. This study aims to i) examine progression of LF antigen (Ag) and microfilaria (Mf) in Ag-positive individuals from 2019-2023; and ii) compare Ag/Mf prevalence in household members of Mf-positive vs Mf-negative participants. In 2023, we tested Ag-positive participants (indexes) from a 2019 survey in Samoa, and their household members. We tested for Ag (Alere/Abbott Filariasis Test Strip) and Mf. We examined changes in Ag/Mf status in index participants and compared Ag/Mf prevalence between household members of Mf-positive and Mf-negative indexes. We recruited 91 indexes and 317 household members. In 2023, all 17 Mf-positive indexes remained Ag-positive and 11/15 with Mf results (73.3%) were Mf-positive. Of 74 Mf-negative indexes, 79.7% remained Ag-positive in 2023 and 31.1% became Mf-positive. Household members of Mf-positive indexes were more likely to be Ag-positive (odds ratios 3.3, 95% CI 1.0-10.3) compared to those of Mf-negative indexes. Our results raise concerns regarding long-term effectiveness of a single-dose of triple-drug MDA for sustained clearance of Mf in Samoa. Guidelines for follow-up and treatment of Ag/Mf-positive people and household members are urgently required.