Metabolic syndrome in carbon disulfide-poisoned subjects in Korea: does chemical poisoning induce metabolic syndrome?

• Published in: International Archives of Occupational and Environmental Health Vol. 82; no. 7; pp. 827 - 832
• Main Authors: Jhun, Hyung-Joon, Lee, Sang-Yoon, Yim, Sang-Hyuk, Kim, Mi-Jung, Park, Kyung-Keun, Cho, Sung-Il
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Science and Business Media LLC 01.07.2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Air Pollutants, Occupational; Air Pollutants, Occupational - poisoning; Biological and medical sciences; Blood pressure; Carbon Disulfide; Carbon Disulfide - poisoning; Earth and Environmental Science; Environment; Environmental Health; Female; Humans; Hypertension; Inhalation Exposure; Korea; Korea - epidemiology; Male; Medical sciences; Metabolic diseases; Metabolic disorders; Metabolic Syndrome; Metabolic Syndrome - diagnosis; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Middle Aged; Miscellaneous; Occupational Diseases; Occupational Diseases - diagnosis; Occupational Diseases - epidemiology; Occupational Diseases - etiology; Occupational Exposure; Occupational Exposure - adverse effects; Occupational Exposure - statistics & numerical data; Occupational Health; Occupational Medicine/Industrial Medicine; Original Article; Other metabolic disorders; Poisoning; Rayon; Rehabilitation; Risk factors; Waist Circumference; Workplace; Asia; Korea; Korea, Rep; Carbon disulfide; Metabolic syndrome; Endocrinopathy; Human; Toxicity; Cellulose hydrate; Metabolic diseases; Cardiovascular disease; Occupational exposure; Risk factor; Poisoning; Occupational medicine; Textile industry
• ISSN: 0340-0131; 1432-1246; 1432-1246
• DOI: 10.1007/s00420-008-0363-8

Objective Mass carbon disulfide (CS 2 ) poisoning was reported at a viscose rayon factory in Korea. We evaluated the association between CS 2 poisoning and the prevalence of metabolic syndrome. Methods The cases ( n  = 170) involved CS 2 -poisoned subjects, who participated in a health examination conducted at a hospital in Korea in 2005. The controls ( n  = 170) were selected randomly from the participants in the third Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined as having at least three of following metabolic abnormalities: abdominal obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose levels. Results After adjusting for covariates (age, gender, education, marital status, alcohol consumption, and smoking), CS 2 -poisoned subjects had an increased risk of metabolic syndrome (prevalence ratio 1.57, 95% CI 1.25–1.98). Conclusions The findings suggest that CS 2 poisoning may increase the risk of metabolic syndrome.