HLA class II alleles may influence susceptibility to adult dermatomyositis and polymyositis in a Han Chinese population

• Published in: BMC dermatology Vol. 14; no. 1; p. 9
• Main Authors: Gao, Xiang, Han, Lei, Yuan, Lan, Yang, Yongchen, Gou, Guimei, Sun, Hengjuan, Lu, Ling, Bao, Liming
• Format: Journal Article
• Language: English
• Published: London BioMed Central 04.06.2014; BioMed Central Ltd
• Subjects: Adult; Aged; Alleles; Allelomorphism; Analysis; Antigens; Asian Continental Ancestry Group - genetics; Autoimmune diseases; Child development; Children & youth; Confidence intervals; Dermatology; Dermatomyositis; Dermatomyositis - genetics; Disease; Female; Gene Frequency; Genetic aspects; Genetic Predisposition to Disease; Haplotypes; Histocompatibility antigens; Histocompatibility Antigens Class II - genetics; HLA histocompatibility antigens; HLA-DQ alpha-Chains - genetics; HLA-DQ beta-Chains - genetics; HLA-DRB1 Chains - genetics; Hospitals; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Pathogenesis; Physiological aspects; Polymorphism, Genetic; Polymyositis; Polymyositis - genetics; Population; Research Article; Risk Factors; Statistical methods; Studies; China; Chinese; Polymyositis; Susceptibility; Dermatomyositis
• ISSN: 1471-5945; 1471-5945
• DOI: 10.1186/1471-5945-14-9

Background Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies. Genetic variability in human leukocyte antigen ( HLA ) genes plays an important role in the pathogenesis of PM and DM. However, few studies on the subject in Chinese populations have been reported thus far. Methods We studied the influence of HLA polymorphisms on DM and PM susceptibility by analyzing HLA-DRB1 , HLA - DQA1 , and HLA - DQB1 alleles in 71 adult DM patients, 20 adult PM patients, and 113 controls in a Han Chinese population. Results A positive association was found between HLA-DQA1 * 0104 and DM ( p  = 0.01; corrected p ( p corr ) NS; odds ratio (OR) = 2.58; 95% confidence interval (CI): 1.18–5.64), while an inverse correlation was noted between HLA-DQB1*0303 and myositis patients with interstitial lung inflammation ( p  = 0.01; p corr NS; OR = 0.25; 95% CI: 0.07–0.73). A positive relationship was also observed between HLA-DRB1*07 and DM ( p  = 0.01; p corr NS; OR = 2.26; 95% CI: 1.12–4.59), while HLA-DRB1*03 seems to be protective against DM ( p  = 0.01; p corr NS; OR = 0.26; 95% CI: 0.06–0.81). The lung complication was closely associated with HLA-DRB1*04 ( p  = 0.01; p corr NS; OR = 2.82; 95% CI: 1.15–6.76) and HLA-DRB1*12 ( p  = 0.02; p corr NS; OR = 2.52; 95% CI: 1.02–6.07). The frequency of HLA-DRB1*07 was significantly higher among myositis patients with dysphagia than among controls ( p  = 0.01; p corr NS; OR = 4.78; 95% CI: 1.03–24.42). The putative haplotype DRB1*07-DQA1*01-DQB1*02 was positively correlated with DM ( p  = 0.03; p corr NS; OR = 2.90; 95% CI: 1.02–8.93) and the lung complication ( p  = 0.02; p corr NS; OR = 3.45; 95% CI: 1.04–11.58). Conclusions Our results demonstrate that HLA alleles may be involved in susceptibility to adult DM and PM in the Han Chinese population.