Effects of Aerobic Exercise vs. Resistance Training on Endothelial Function in Women with Type 2 Diabetes Mellitus

• Published in: Diabetes & metabolism journal Vol. 35; no. 4; pp. 364 - 373
• Main Authors: Kwon, Hwi Ryun, Min, Kyung Wan, Ahn, Hee Jung, Seok, Hee Geum, Lee, Jae Hyuk, Park, Gang Seo, Han, Kyung Ah
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Diabetes Association / Daehan Dangnyobyeong Hakoe 01.08.2011; Korean Diabetes Association; 대한당뇨병학회
• Subjects: Accelerometers; Aerobic exercise; Aerobics; Antihypertensives; Bioavailability; Blood pressure; Cardiovascular disease; Cholesterol; Diabetes; Diabetes mellitus, type 2; Drug dosages; Endothelial function; Energy intake; Exercise; Glucose; Heart failure; Hemoglobin; Nitric oxide; Original; Performance evaluation; Physical fitness; Resistance training; Smooth muscle; Strength training; Womens health; 내과학; United States > US; Japan; Endothelial function; Diabetes mellitus, type 2; Resistance training; Aerobic exercise
• ISSN: 2233-6079; 2233-6087; 2233-6087
• DOI: 10.4093/dmj.2011.35.4.364

There is controversy over whether aerobic or resistance exercise is more effective for improving endothelial function in type 2 diabetes mellitus (T2DM). This study was aimed to investigate the effects of an aerobic and resistance training program on endothelial function, and the influences of glycemic control, body weight changes, and aerobic capacity in T2DM. Total 40 overweight women with T2DM were assigned into 3 groups: an aerobic exercise group (AEG, n=13), resistance exercise group (REG, n=12), and control group (CG, n=15), and followed either brisk walking for the AEG or resistance band training for the REG, 60 minutes per day, 5 days per week for 12 weeks with monitoring daily activity using accelerometers. We assessed endothelial function by flow-mediated dilation (FMD), and aerobic capacity by oxygen uptake at anaerobic threshold (AT_VO(2)) at baseline and following training program. The mean participants' age was 57.0±6.8 years, and body mass index (BMI) was 27.0±2.3 kg/m(2). After intervention, FMD increased by 2.2±1.9% in AEG, which differed from REG and CG (P=0.002), despite of decreased body weight (BW) in both AG and RG (2.8±2.5%, P=0.002; 1.6±2.0%, P=0.017, respectively). A significant increased AT_VO(2) and decreased HbA1c were found only in AEG. In all participants, FMD was changed with the significant relations to the AT_VO(2) (r=0.348, P=0.035), but not to HbA1c levels or BW. Aerobic exercise appears to be more beneficial than resistance exercise for improving endothelial function in T2DM. In addition, aerobic capacity could be a better predictor of changes in FMD than BW and glycemic control.