High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil

• Published in: NeuroImage (Orlando, Fla.) Vol. 150; pp. 262 - 269
• Main Authors: Navarro de Lara, Lucia I., Tik, Martin, Woletz, Michael, Frass-Kriegl, Roberta, Moser, Ewald, Laistler, Elmar, Windischberger, Christian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2017; Elsevier Limited
• Subjects: Adult; Brain Mapping - instrumentation; Brain Mapping - methods; Brain research; Coil array; concurrent TMS/fMRI; Cortex (motor); Data processing; Experiments; Female; fMRI; Functional magnetic resonance imaging; Hand; Humans; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Male; Medical imaging; motor cortex; Motor Cortex - physiology; Motor task performance; NMR; Nuclear magnetic resonance; parallel imaging; Scalp; TMS; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - instrumentation; Transcranial Magnetic Stimulation - methods; Coil array; fMRI; parallel imaging; motor cortex; TMS; concurrent TMS/fMRI
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2017.02.062

To validate a novel setup for concurrent TMS/fMRI in the human motor cortex based on a dedicated, ultra-thin, multichannel receive MR coil positioned between scalp and TMS system providing greatly enhanced sensitivity compared to the standard birdcage coil setting. A combined TMS/fMRI design was applied over the primary motor cortex based on 1Hz stimulation with stimulation levels of 80%, 90%, 100%, and 110% of the individual active motor threshold, respectively. Due to the use of a multichannel receive coil we were able to use multiband-accelerated (MB=2) EPI sequences for the acquisition of functional images. Data were analysed with SPM12 and BOLD-weighted signal intensity time courses were extracted in each subject from two local maxima (individual functional finger tapping localiser, fixed MNI coordinate of the hand knob) next to the hand area of the primary motor cortex (M1) and from the global maximum. We report excellent image quality without noticeable signal dropouts or image distortions. Parameter estimates in the three peak voxels showed monotonically ascending activation levels over increasing stimulation intensities. Across all subjects, mean BOLD signal changes for 80%, 90%, 100%, 110% of the individual active motor threshold were 0.43%, 0.63%, 1.01%, 2.01% next to the individual functional finger tapping maximum, 0.73%, 0.91%, 1.34%, 2.21% next to the MNI-defined hand knob and 0.88%, 1.09%, 1.65%, 2.77% for the global maximum, respectively. Our results show that the new setup for concurrent TMS/fMRI experiments using a dedicated MR coil array allows for high-sensitivity fMRI particularly at the site of stimulation. Contrary to the standard birdcage approach, the results also demonstrate that the new coil can be successfully used for multiband-accelerated EPI acquisition. The gain in flexibility due to the new coil can be easily combined with neuronavigation within the MR scanner to allow for accurate targeting in TMS/fMRI experiments.