Seronegative Full-house Nephropathy with Crohn's Disease

• Published in: Internal Medicine Vol. 61; no. 23; pp. 3553 - 3558
• Main Authors: Nishide, Kozo, Uedono, Hideki, Natsuki, Yuka, Emoto, Masanori, Nakatani, Shinya, Ueno, Noriko, Nakaya, Rino, Fujimoto, Kenta, Tsuda, Akihiro, Machiba, Yuri, Mori, Katsuhito
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.12.2022; Japan Science and Technology Agency
• Subjects: Case Report; Crohn Disease - complications; Crohn Disease - drug therapy; Crohn's disease; full-house nephropathy; Glomerulonephritis; Glomerulonephritis, IGA - complications; Glomerulonephritis, IGA - diagnosis; Humans; IgA nephropathy; Immunofluorescence; Immunoglobulin A; Inflammatory bowel diseases; Internal medicine; Lupus Erythematosus, Systemic - complications; Lupus nephritis; Lupus Nephritis - complications; Lupus Nephritis - diagnosis; Lupus Nephritis - drug therapy; Monoclonal antibodies; Nephritis; Patients; Proteinuria; Proteinuria - complications; Risk factors; Steroid hormones; Systemic lupus erythematosus; full-house nephropathy; Crohn's disease; IgA nephropathy
• ISSN: 0918-2918; 1349-7235; 1349-7235
• DOI: 10.2169/internalmedicine.8820-21

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular "full-house" immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can also present with a "full-house" immunofluorescence pattern. We recently encountered a patient with full-house nephropathy (FHN) during adalimumab administration for Crohn's disease. IgA nephropathy or idiopathic FHN was diagnosed, and treatment with steroids was started, after which there was improvement in proteinuria. The prognosis of FHN has been reported to be poor; therefore, aggressive treatment is required for such patients.