Signal intensity of cerebral gyri in corticobasal syndrome on phase difference enhanced magnetic resonance images: Comparison of progressive supranuclear palsy and Parkinson's disease

• Published in: Journal of the neurological sciences Vol. 419; p. 117210
• Main Authors: Miyata, Mari, Kakeda, Shingo, Yoneda, Tetsuya, Ide, Satoru, Okada, Kazumasa, Adachi, Hiroaki, Korogi, Yukunori
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2020
• Subjects: Cerebral Cortex - diagnostic imaging; Corticobasal syndrome; Humans; Magnetic Resonance Imaging; Neurology; PADRE; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson's disease; Phase difference enhanced imaging; Progressive supranuclear palsy; Supranuclear Palsy, Progressive - diagnostic imaging; White Matter - diagnostic imaging; SCWM; PADRE; Parkinson's disease; CBD; CG; GM; HS; PSP; Corticobasal syndrome; PD; Progressive supranuclear palsy; CBS; SI; Phase difference enhanced imaging; FLAIR; corticobasal degeneration; signal intensity; healthy subject; subcortical white matter; gray matter; fluid-attenuated inversion recovery; cerebral gyri
• ISSN: 0022-510X; 1878-5883; 1878-5883
• DOI: 10.1016/j.jns.2020.117210

We evaluated cerebral gyri (CG) on phase difference enhanced imaging (PADRE) of corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Parkinson's disease (PD) patients to determine whether it is possible to discriminate among them on an individual basis. Two radiologists reviewed appearance of the normal CG and that of CBS patients on PADRE, and deviations from the appearance of the normal CG were recorded. Next, based on the CG abnormalities, two other reviewers reviewed PADRE images from 12 CBS, 14 PSP, and 30 PD patients. In healthy subjects on the PADRE images, the signal intensity (SI) of the gray matter (GM) was homogeneously, slightly hyperintense to the subcortical white matter (SCWM), and the SI of the SCWM was homogeneously hypointense. In CBS patients, hypointense layer in superficial GM and disappearance of hypointense in SCWM. The frequency of the abnormal findings on PADRE in the blinded manner by two readers was 100% (12/12), 3% (1/30), and 29% (4/14 in Reader 1) or 36% (5/14 in Reader 2) in CBS PD, and PSP patients, respectively. Laterality of the PADRE findings was showed in 12 (100%) CBS patients and 3 (21%) PSP, but not in any PD patients. The previously reported typical findings in CBS on conventional magnetic resonance image (MRIs) were observed in only 42% (5/12) of CBS patients. In conclusion, the abnormal findings in CG on PADRE appears more useful than conventional MRI findings for discriminating CBS from PD on an individual basis. •We evaluated cerebral gyri on PADRE in CBS, PSP, PD and HS.•The SI of the SCWM on PADRE was hypointense related to myelin density on HS.•CBS revealed hypointense in GM and disappearance of hypointense in SCWM on PADRE.•Abnormal PADRE findings can discriminate CBS from PD.•Typical findings of CBS on conventional MRI may be non-specific.