Cell biological basis for combination radiotherapy using heavy-ion beams and high-energy X-rays
We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information a...
Saved in:
| Published in | Radiotherapy and oncology Vol. 71; no. 2; pp. 207 - 211 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
01.05.2004
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0167-8140 1879-0887 |
| DOI | 10.1016/j.radonc.2004.03.008 |
Cover
| Abstract | We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray. |
|---|---|
| AbstractList | We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray. We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray.We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray. |
| Author | Ejima, Yasuo Yanou, Toshihiro Hishikawa, Yoshio Sugimura, Kazuro Kagawa, Kazufumi Demizu, Yusuke Furusawa, Yoshiya Shimizu, Masakazu Nishimura, Hideki Sasaki, Ryohei Soejima, Toshinori |
| Author_xml | – sequence: 1 givenname: Yusuke surname: Demizu fullname: Demizu, Yusuke organization: Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan – sequence: 2 givenname: Kazufumi surname: Kagawa fullname: Kagawa, Kazufumi organization: Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo, Japan – sequence: 3 givenname: Yasuo surname: Ejima fullname: Ejima, Yasuo organization: Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan – sequence: 4 givenname: Hideki surname: Nishimura fullname: Nishimura, Hideki organization: Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan – sequence: 5 givenname: Ryohei surname: Sasaki fullname: Sasaki, Ryohei organization: Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan – sequence: 6 givenname: Toshinori surname: Soejima fullname: Soejima, Toshinori organization: Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan – sequence: 7 givenname: Toshihiro surname: Yanou fullname: Yanou, Toshihiro organization: Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo, Japan – sequence: 8 givenname: Masakazu surname: Shimizu fullname: Shimizu, Masakazu organization: Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo, Japan – sequence: 9 givenname: Yoshiya surname: Furusawa fullname: Furusawa, Yoshiya organization: Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan – sequence: 10 givenname: Yoshio surname: Hishikawa fullname: Hishikawa, Yoshio organization: Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo, Japan – sequence: 11 givenname: Kazuro surname: Sugimura fullname: Sugimura, Kazuro organization: Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15110455$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1q3DAURkVJaCZp36AUrbqzeyXbI08phTD0JxDIJoXuxLV0PaOpLU0lT8BvX00n7SKLZiWBvvPp6uiSnfngibE3AkoBYvl-V0a0wZtSAtQlVCVA-4ItRKtWBbStOmOLHFNFK2q4YJcp7QBAQqVesgvRCAF10yyYXtMw8M6FIWycwbzF5BLvQ-QmjJ3zOLngeb7KhWlLEfczPyTnN3xL-DAXx8OOcEwcveVbt9kW5CluZv6jiDinV-y8xyHR68f1in3_8vl-_a24vft6s76-LUwjq6kwxlQd9Uuxsl2LlnoiJZWURkKeta-bThCtUJp2CQ0gUr-yyoIVVqiMLqsr9u7Uu4_h14HSpEeXTH4begqHpFX2UsuqycG3j8FDN5LV--hGjLP-qyQHPpwCJoaUIvXauOmPhSmiG7QAffSvd_rkXx_9a6h09p_h-gn8r___2KcTRlnRg6Ook3HkDVkXyUzaBvdcwccnBWZw_vihP2l-Hv8NI-q3KA |
| CitedBy_id | crossref_primary_10_1269_jrr_08070 crossref_primary_10_1016_j_radonc_2006_07_017 crossref_primary_10_1016_j_ijrobp_2008_12_092 crossref_primary_10_1111_j_1349_7006_2008_00771_x crossref_primary_10_1016_j_radmp_2024_10_004 crossref_primary_10_1259_bjr_20130512 crossref_primary_10_1080_09553000601085964 crossref_primary_10_1007_s00411_012_0417_x crossref_primary_10_1016_j_bbrc_2012_06_004 crossref_primary_10_2209_tdcpublication_48_177 crossref_primary_10_1016_j_ijrobp_2006_02_048 crossref_primary_10_1016_j_lssr_2018_10_003 crossref_primary_10_1371_journal_pone_0286902 crossref_primary_10_1038_s41598_023_38295_3 crossref_primary_10_3892_etm_2012_474 crossref_primary_10_1667_RR15456_1 crossref_primary_10_1016_j_lssr_2016_02_001 crossref_primary_10_1111_j_1349_7006_2008_00818_x crossref_primary_10_3390_biology12030400 crossref_primary_10_1016_j_ijrobp_2008_12_068 crossref_primary_10_3390_cancers13205232 |
| Cites_doi | 10.1016/S0167-8140(02)00153-6 10.1007/s00066-003-1071-7 10.1016/S0360-3016(01)02827-9 10.1016/S0360-3016(02)02949-8 10.1016/j.ijrobp.2003.09.041 10.1016/S0167-8140(02)00367-5 10.2307/3575352 10.1269/jrr.43.257 10.2307/3578217 10.2307/3575541 10.1016/S0360-3016(02)04511-X 10.1080/09553008414551811 10.2307/3576024 10.1016/S0273-1177(02)00409-X 10.1080/09553008414550441 10.2307/3570859 10.1200/JCO.2002.10.050 |
| ContentType | Journal Article |
| Copyright | 2004 Elsevier Ireland Ltd |
| Copyright_xml | – notice: 2004 Elsevier Ireland Ltd |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.radonc.2004.03.008 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1879-0887 |
| EndPage | 211 |
| ExternalDocumentID | 15110455 10_1016_j_radonc_2004_03_008 S0167814004001379 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXUO ABBQC ABFNM ABJNI ABMAC ABOCM ABUDA ABWVN ABXDB ACDAQ ACGFS ACIEU ACIUM ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEHWI AEIPS AEKER AENEX AEUPX AFPUW AFTJW AFXIZ AGUBO AGYEJ AHHHB AIEXJ AIIUN AIKHN AITUG AJRQY AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX AXJTR BKOJK BLXMC BNPGV CS3 DU5 E3Z EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q HMK HZ~ IHE J1W KOM M27 M41 MO0 N9A O-L O9- OAUVE OZT P-9 P2P PC. Q38 ROL RPZ SDF SDG SEL SES SPCBC SSH SSU SSZ T5K UV1 ~G- ~HD AACTN AAIAV ABLVK ABYKQ AFCTW AFKWA AJBFU AJOXV AMFUW LCYCR RIG .1- .55 .FO .GJ 1P~ AAQXK AAYWO AAYXX ABMZM ADVLN AEBSH AEVXI AFJKZ AFRHN AGHFR AGQPQ AIGII AJUYK APXCP ASPBG AVWKF AZFZN CITATION FEDTE FGOYB G-2 GBLVA HED HMO HVGLF J5H OC~ OO- P-8 R2- SAE SEW WUQ X7M Z5R ZGI ZXP 0SF CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c523t-ccc3bef619db8adefee72722c20151f45b1ee9a2c86050aaef9d7d0d1d17cc363 |
| IEDL.DBID | AIKHN |
| ISSN | 0167-8140 |
| IngestDate | Mon Sep 29 06:09:58 EDT 2025 Wed Feb 19 01:35:26 EST 2025 Wed Oct 01 02:14:47 EDT 2025 Thu Apr 24 22:58:44 EDT 2025 Fri Feb 23 02:16:54 EST 2024 Tue Oct 14 19:36:17 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Irradiation Carbon-beam Radiosensitivity X-ray Linear energy transfer Combination |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c523t-ccc3bef619db8adefee72722c20151f45b1ee9a2c86050aaef9d7d0d1d17cc363 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 15110455 |
| PQID | 71874235 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_71874235 pubmed_primary_15110455 crossref_citationtrail_10_1016_j_radonc_2004_03_008 crossref_primary_10_1016_j_radonc_2004_03_008 elsevier_sciencedirect_doi_10_1016_j_radonc_2004_03_008 elsevier_clinicalkey_doi_10_1016_j_radonc_2004_03_008 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2004-05-01 |
| PublicationDateYYYYMMDD | 2004-05-01 |
| PublicationDate_xml | – month: 05 year: 2004 text: 2004-05-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Radiotherapy and oncology |
| PublicationTitleAlternate | Radiother Oncol |
| PublicationYear | 2004 |
| Publisher | Elsevier Ireland Ltd |
| Publisher_xml | – name: Elsevier Ireland Ltd |
| References | Furusawa, Aoki, Durante (BIB3) 2002; 30 Suzuki, Miura, Mizuno, Furusawa (BIB18) 2002; 43 Hall (BIB4) 2000 Miyamoto, Yamamoto, Nishimura (BIB9) 2003; 66 Schulz-Ertner, Nikoghosyan, Thilmann (BIB16) 2004; 58 McNally, de Ronde, Hinchliffe (BIB8) 1984; 45 Kamada, Tsujii, Tsuji (BIB7) 2002; 20 Schulz-Ertner, Haberer, Jäkel (BIB13) 2002; 53 Suzuki (BIB17) 1993; 133 Kagawa, Murakami, Hishikawa (BIB6) 2002; 54 Schulz-Ertner, Didinger, Nikoghosyan (BIB12) 2003; 179 Schulz-Ertner, Nikoghosyan, Jäkel (BIB15) 2003; 56 Zaider, Rossi (BIB19) 1980; 83 Schulz-Ertner, Haberer, Scholz (BIB14) 2002; 64 Nakano, Suzuki, Abe (BIB10) 1999; 5 Ngo, Blakely, Tobias (BIB11) 1981; 87 Bird, Zaider, Rossi (BIB2) 1983; 93 Joiner, Bremner, Denekamp (BIB5) 1984; 46 Barendsen, Beusker, Vergroesen, Budke (BIB1) 1960; 13 Ngo (10.1016/j.radonc.2004.03.008_BIB11) 1981; 87 Suzuki (10.1016/j.radonc.2004.03.008_BIB17) 1993; 133 Bird (10.1016/j.radonc.2004.03.008_BIB2) 1983; 93 Miyamoto (10.1016/j.radonc.2004.03.008_BIB9) 2003; 66 Zaider (10.1016/j.radonc.2004.03.008_BIB19) 1980; 83 Barendsen (10.1016/j.radonc.2004.03.008_BIB1) 1960; 13 Schulz-Ertner (10.1016/j.radonc.2004.03.008_BIB12) 2003; 179 Schulz-Ertner (10.1016/j.radonc.2004.03.008_BIB15) 2003; 56 McNally (10.1016/j.radonc.2004.03.008_BIB8) 1984; 45 Schulz-Ertner (10.1016/j.radonc.2004.03.008_BIB13) 2002; 53 Furusawa (10.1016/j.radonc.2004.03.008_BIB3) 2002; 30 Kagawa (10.1016/j.radonc.2004.03.008_BIB6) 2002; 54 Suzuki (10.1016/j.radonc.2004.03.008_BIB18) 2002; 43 Joiner (10.1016/j.radonc.2004.03.008_BIB5) 1984; 46 Kamada (10.1016/j.radonc.2004.03.008_BIB7) 2002; 20 Schulz-Ertner (10.1016/j.radonc.2004.03.008_BIB16) 2004; 58 Schulz-Ertner (10.1016/j.radonc.2004.03.008_BIB14) 2002; 64 Hall (10.1016/j.radonc.2004.03.008_BIB4) 2000 Nakano (10.1016/j.radonc.2004.03.008_BIB10) 1999; 5 |
| References_xml | – volume: 93 start-page: 444 year: 1983 end-page: 452 ident: BIB2 article-title: The sequential irradiation of mammalian cells with X rays and charged particles of high LET publication-title: Radiat Res – volume: 66 start-page: 127 year: 2003 end-page: 140 ident: BIB9 article-title: Carbon ion radiotherapy for stage I non-small cell lung cancer publication-title: Radiother Oncol – volume: 179 start-page: 345 year: 2003 end-page: 351 ident: BIB12 article-title: Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost publication-title: Strahlenther Onkol – volume: 43 start-page: 257 year: 2002 end-page: 267 ident: BIB18 article-title: Models for mixed irradiation with a ‘reciprocal-time’ pattern of the repair function publication-title: J Radiat Res – volume: 5 start-page: 362 year: 1999 end-page: 369 ident: BIB10 article-title: The phase I/II clinical study of carbon ion therapy for cancer of the uterine cervix publication-title: Cancer J Sci Am – volume: 53 start-page: 36 year: 2002 end-page: 42 ident: BIB13 article-title: Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions publication-title: Int J Radiat Oncol Biol Phys – volume: 133 start-page: 327 year: 1993 end-page: 333 ident: BIB17 article-title: Survival of Chinese hamster V79 cells after irradiation with a mixture of neutrons and publication-title: Radiat Res – volume: 13 start-page: 841 year: 1960 end-page: 849 ident: BIB1 article-title: Effects of different ionizing radiations on human cells in tissue culture publication-title: Radiat Res – volume: 87 start-page: 59 year: 1981 end-page: 78 ident: BIB11 article-title: Sequential exposures of mammalian cells to low- and high-LET radiations. I. Lethal effects following X-ray and neon irradiation publication-title: Radiat Res – volume: 64 start-page: 189 year: 2002 end-page: 195 ident: BIB14 article-title: Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumors publication-title: Radiother Oncol – volume: 20 start-page: 4466 year: 2002 end-page: 4471 ident: BIB7 article-title: Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas publication-title: J Clin Oncol – volume: 56 start-page: 391 year: 2003 end-page: 398 ident: BIB15 article-title: Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas publication-title: Int J Radiat Oncol Biol Phys – volume: 30 start-page: 877 year: 2002 end-page: 884 ident: BIB3 article-title: Simultaneous exposure of mammalian cells to heavy ions and X-rays publication-title: Adv Space Res – volume: 54 start-page: 928 year: 2002 end-page: 938 ident: BIB6 article-title: Preclinical biological assessment of proton and carbon-beams at Hyogo Ion Beam Medical Center publication-title: Int J Radiat Oncol Biol Phys – volume: 46 start-page: 625 year: 1984 end-page: 638 ident: BIB5 article-title: The interaction between X-rays and 3 publication-title: Int J Radiat Biol – volume: 45 start-page: 301 year: 1984 end-page: 310 ident: BIB8 article-title: The effect of sequential irradiation with X-rays and fast neutrons on the survival of V79 Chinese hamster cells publication-title: Int J Radiat Biol – volume: 58 start-page: 631 year: 2004 end-page: 640 ident: BIB16 article-title: Results of carbon ion radiotherapy in 152 patients publication-title: Int J Radiat Oncol Biol Phys – start-page: 67 year: 2000 end-page: 90 ident: BIB4 article-title: Repair of radiation damage and the dose–rate effect publication-title: Radiobiology for the radiologist – volume: 83 start-page: 732 year: 1980 end-page: 739 ident: BIB19 article-title: The synergistic effects of different radiations publication-title: Radiat Res – start-page: 67 year: 2000 ident: 10.1016/j.radonc.2004.03.008_BIB4 article-title: Repair of radiation damage and the dose–rate effect – volume: 64 start-page: 189 year: 2002 ident: 10.1016/j.radonc.2004.03.008_BIB14 article-title: Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumors publication-title: Radiother Oncol doi: 10.1016/S0167-8140(02)00153-6 – volume: 179 start-page: 345 year: 2003 ident: 10.1016/j.radonc.2004.03.008_BIB12 article-title: Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost publication-title: Strahlenther Onkol doi: 10.1007/s00066-003-1071-7 – volume: 53 start-page: 36 year: 2002 ident: 10.1016/j.radonc.2004.03.008_BIB13 article-title: Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(01)02827-9 – volume: 54 start-page: 928 year: 2002 ident: 10.1016/j.radonc.2004.03.008_BIB6 article-title: Preclinical biological assessment of proton and carbon-beams at Hyogo Ion Beam Medical Center publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(02)02949-8 – volume: 58 start-page: 631 year: 2004 ident: 10.1016/j.radonc.2004.03.008_BIB16 article-title: Results of carbon ion radiotherapy in 152 patients publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2003.09.041 – volume: 5 start-page: 362 year: 1999 ident: 10.1016/j.radonc.2004.03.008_BIB10 article-title: The phase I/II clinical study of carbon ion therapy for cancer of the uterine cervix publication-title: Cancer J Sci Am – volume: 66 start-page: 127 year: 2003 ident: 10.1016/j.radonc.2004.03.008_BIB9 article-title: Carbon ion radiotherapy for stage I non-small cell lung cancer publication-title: Radiother Oncol doi: 10.1016/S0167-8140(02)00367-5 – volume: 83 start-page: 732 year: 1980 ident: 10.1016/j.radonc.2004.03.008_BIB19 article-title: The synergistic effects of different radiations publication-title: Radiat Res doi: 10.2307/3575352 – volume: 43 start-page: 257 year: 2002 ident: 10.1016/j.radonc.2004.03.008_BIB18 article-title: Models for mixed irradiation with a ‘reciprocal-time’ pattern of the repair function publication-title: J Radiat Res doi: 10.1269/jrr.43.257 – volume: 133 start-page: 327 year: 1993 ident: 10.1016/j.radonc.2004.03.008_BIB17 article-title: Survival of Chinese hamster V79 cells after irradiation with a mixture of neutrons and 60Co γ rays: experimental and theoretical analysis of mixed irradiation publication-title: Radiat Res doi: 10.2307/3578217 – volume: 87 start-page: 59 year: 1981 ident: 10.1016/j.radonc.2004.03.008_BIB11 article-title: Sequential exposures of mammalian cells to low- and high-LET radiations. I. Lethal effects following X-ray and neon irradiation publication-title: Radiat Res doi: 10.2307/3575541 – volume: 56 start-page: 391 year: 2003 ident: 10.1016/j.radonc.2004.03.008_BIB15 article-title: Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(02)04511-X – volume: 46 start-page: 625 year: 1984 ident: 10.1016/j.radonc.2004.03.008_BIB5 article-title: The interaction between X-rays and 3MeV neutrons in the skin of the mouse foot publication-title: Int J Radiat Biol doi: 10.1080/09553008414551811 – volume: 93 start-page: 444 year: 1983 ident: 10.1016/j.radonc.2004.03.008_BIB2 article-title: The sequential irradiation of mammalian cells with X rays and charged particles of high LET publication-title: Radiat Res doi: 10.2307/3576024 – volume: 30 start-page: 877 year: 2002 ident: 10.1016/j.radonc.2004.03.008_BIB3 article-title: Simultaneous exposure of mammalian cells to heavy ions and X-rays publication-title: Adv Space Res doi: 10.1016/S0273-1177(02)00409-X – volume: 45 start-page: 301 year: 1984 ident: 10.1016/j.radonc.2004.03.008_BIB8 article-title: The effect of sequential irradiation with X-rays and fast neutrons on the survival of V79 Chinese hamster cells publication-title: Int J Radiat Biol doi: 10.1080/09553008414550441 – volume: 13 start-page: 841 year: 1960 ident: 10.1016/j.radonc.2004.03.008_BIB1 article-title: Effects of different ionizing radiations on human cells in tissue culture publication-title: Radiat Res doi: 10.2307/3570859 – volume: 20 start-page: 4466 year: 2002 ident: 10.1016/j.radonc.2004.03.008_BIB7 article-title: Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas publication-title: J Clin Oncol doi: 10.1200/JCO.2002.10.050 |
| SSID | ssj0002037 |
| Score | 1.8775445 |
| Snippet | We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 207 |
| SubjectTerms | Apoptosis - radiation effects Carbon Carbon-beam Cell Line, Tumor Cell Survival - radiation effects Cells, Cultured - radiation effects Combination Combined Modality Therapy Dose-Response Relationship, Radiation Humans Irradiation Linear energy transfer Linear Energy Transfer - radiation effects Radiation Dosage Radiosensitivity Radiotherapy, High-Energy - methods Reference Values Relative Biological Effectiveness Salivary Gland Neoplasms - pathology Sensitivity and Specificity X-ray |
| Title | Cell biological basis for combination radiotherapy using heavy-ion beams and high-energy X-rays |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0167814004001379 https://dx.doi.org/10.1016/j.radonc.2004.03.008 https://www.ncbi.nlm.nih.gov/pubmed/15110455 https://www.proquest.com/docview/71874235 |
| Volume | 71 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier ScienceDirect customDbUrl: eissn: 1879-0887 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0002037 issn: 0167-8140 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1879-0887 dateEnd: 20130228 omitProxy: true ssIdentifier: ssj0002037 issn: 0167-8140 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1879-0887 dateEnd: 20130228 omitProxy: true ssIdentifier: ssj0002037 issn: 0167-8140 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1879-0887 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0002037 issn: 0167-8140 databaseCode: AKRWK dateStart: 19830801 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB4lqYS4IFpegZLugesS2-v141hFjdICFQIq5bbaxxgFBadKUqRc-O3M2usgDlFRr7ZH3p2ZnYd25huAdyIyukBpeZzKiqclSl5mMueZy6TJCp2jawpkr7PZTXo1l_MeTLpeGF9WGWx_a9Mbax2ejAM3x7eLxfirL6D3eE1eDWORl304Iv9TFAM4Or_8MLveG-QkaqEzPcS3J-g66Joyr7V2q7rBMkwD2ukhD3UoAm080fQpPAkhJDtvV3kMPaxP4NGncEn-DNQEl0vWoit5ETDyVIsNo-iU0S4pE26EwWhJi9B-tWO-_P07I8P8a8f9S4P654bp2jGPZ8yx6RBkc77Wu81zuJlefJvMeJijwC2lmVturRUGK0qVnCm0wwrRX78mlpy_jKtUmhix1IktKLeJtMaqdLmLXOzinEgz8QIG9arGV8BEIrSxZYYUudFpl4WzzliLhZaxS0Q5BNHxTtkAMu5nXSxVV032Q7Uc9_MvUxUJRRwfAt9T3bYgG_d8LzuxqK6BlEyeIi9wD12-p_tHyf6D8qyTvqLz5y9VdI2ru43K_VDDRMghvGyV4u8OKJalgFm-fvBf38DjtlDI11eewmC7vsO3FANtzQj673_HI9L0yZePn0dB4_8AHnQIeQ |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VIgGXijdpge6B6xLb6_XjWEVUAdpeaKXcVvsYo6DgVEmKlEt_e2fsdSsOVRFX2yPvY3Ye2m--AfikEmcr1F6muW5kXqOWdaFLWYRCu6KyJYYOIHtWTC_ybzM924HJUAvDsMpo-3ub3lnr-GQcV3N8OZ-PfzCAnvmaWA1TVdaP4HGus5IzsM_XdziPLOmJM5ngmz8f6uc6kNfKhmXbMRnmkev0Pv90X_zZ-aHj57AXA0hx1I_xBexg-xKenMYr8ldgJrhYiJ5biTdAkJ-arwXFpoLmSHlwtxWChjSPxVdbweD3n4LM8p-t5JcO7e-1sG0QzGYssasPFDO5stv1a7g4_nI-mcrYRUF6SjI30nuvHDaUKAVX2YANIl--Zp5cv06bXLsUsbaZryizSazFpg5lSEIa0pJEC_UGdttli-9AqExZ5-sCKW6js66r4IPzHiur05CpegRqWDvjI8U4d7pYmAFL9sv0K87dL3OTKEMrPgJ5K3XZU2w88L0etsUM5aNk8Az5gAfkylu5v1TsHyQPh903dPr4SsW2uLxam5JbGmZKj-BtrxR3M6BIlsJlvf_ffz2Ep9Pz0xNz8vXs-wE86yFDjLR8D7ub1RV-oGho4z522n4DFmEHrA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cell+biological+basis+for+combination+radiotherapy+using+heavy-ion+beams+and+high-energy+X-rays&rft.jtitle=Radiotherapy+and+oncology&rft.au=Demizu%2C+Yusuke&rft.au=Kagawa%2C+Kazufumi&rft.au=Ejima%2C+Yasuo&rft.au=Nishimura%2C+Hideki&rft.date=2004-05-01&rft.issn=0167-8140&rft.volume=71&rft.issue=2&rft.spage=207&rft_id=info:doi/10.1016%2Fj.radonc.2004.03.008&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0167-8140&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0167-8140&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0167-8140&client=summon |