Cell biological basis for combination radiotherapy using heavy-ion beams and high-energy X-rays

• Published in: Radiotherapy and oncology Vol. 71; no. 2; pp. 207 - 211
• Main Authors: Demizu, Yusuke, Kagawa, Kazufumi, Ejima, Yasuo, Nishimura, Hideki, Sasaki, Ryohei, Soejima, Toshinori, Yanou, Toshihiro, Shimizu, Masakazu, Furusawa, Yoshiya, Hishikawa, Yoshio, Sugimura, Kazuro
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.05.2004
• Subjects: Apoptosis - radiation effects; Carbon; Carbon-beam; Cell Line, Tumor; Cell Survival - radiation effects; Cells, Cultured - radiation effects; Combination; Combined Modality Therapy; Dose-Response Relationship, Radiation; Humans; Irradiation; Linear energy transfer; Linear Energy Transfer - radiation effects; Radiation Dosage; Radiosensitivity; Radiotherapy, High-Energy - methods; Reference Values; Relative Biological Effectiveness; Salivary Gland Neoplasms - pathology; Sensitivity and Specificity; X-ray; Irradiation; Carbon-beam; Radiosensitivity; X-ray; Linear energy transfer; Combination
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/j.radonc.2004.03.008

We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray.