Relationship Between Serum Selenium Concentration and Neutrophil Function in Peripheral Blood

• Published in: Biological Trace Element Research Vol. 144; no. 1-3; pp. 396 - 406
• Main Authors: Lee, Sangun, Takahashi, Ippei, Matsuzaka, Masashi, Yamai, Kiyonori, Danjo, Kazuma, Kumagai, Takako, Umeda, Takashi, Itai, Kazuyoshi, Nakaji, Shigeyuki
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.12.2011; Springer Science and Business Media LLC; Humana Press Inc; Springer Nature B.V
• Subjects: Adult; Aged; Alcohol Drinking; Alcohol Drinking - blood; Biochemistry; Biomedical and Life Sciences; Biotechnology; Blood; blood serum; Body Composition; Body Mass Index; Cell Separation; Chemiluminescence; diagnostic use; Exercise; Exercise - physiology; Female; Health promotion; Humans; Life Sciences; Life Style; Luminescence; Male; men; Middle Aged; Neutrophils; Neutrophils - physiology; Nutrition; Oncology; Opsonin Proteins; Opsonin Proteins - blood; Oxidative Stress; Phagocytosis; physiology; production functions; Reactive Oxygen Species; Reactive Oxygen Species - blood; Selenium; Selenium - blood; Sex Characteristics; Smoking; Smoking - blood; women; Zymosan; Phagocytic activity; Serum opsonic activity; Selenium; Neutrophil; Oxidative burst activity
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-011-9108-8

We evaluated the relationships between neutrophil-related functions and serum selenium (Se) concentration in the general population. We examined 800 subjects who had participated in the Iwaki Health Promotion Project in 2005 to determine the relationships between serum Se concentration and neutrophil-related functions such as the production capability of reactive oxygen species (ROS), phagocytic activity, and serum opsonic activity (SOA). In nonstimulated neutrophils, i.e., in neutrophils at their baseline condition before the application of the phagocytic stimulus, the serum Se concentration tends to be high and the ROS production tends to be low. With regard to SOA, there was a significant negative correlation between lucigenin-dependent chemiluminescence and serum Se concentration in both men and women. Moreover, in women, a significant negative correlation was observed between luminol-dependent chemiluminescence and serum Se concentration. These results suggest that subjects with a lower serum Se concentration may be exposed to a greater chronic oxidative stress due to neutrophil ROS production. In addition, the findings of our study suggest that women rather than men benefit more from Se against oxidative stress.