Crucial Role of Extracellular Vesicles in Bronchial Asthma

• Published in: International journal of molecular sciences Vol. 20; no. 10; p. 2589
• Main Authors: Nagano, Tatsuya, Katsurada, Masahiro, Dokuni, Ryota, Hazama, Daisuke, Kiriu, Tatsunori, Umezawa, Kanoko, Kobayashi, Kazuyuki, Nishimura, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.05.2019; MDPI
• Subjects: Allergies; Angiogenesis; Asthma; Biomarkers; Cell adhesion & migration; Chemokines; Cytokines; Extracellular vesicles; Fibroblasts; Homeostasis; Inflammation; Inflammatory diseases; Kinases; Lymphocytes; MicroRNAs; Neutrophils; Pathogenesis; Peptides; Proteins; Respiratory system; Review; Roles; Transcription factors; microparticles; extracellular vesicles; exosomes; apoptotic bodies
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20102589

Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis because they contain intracellular proteins and nucleic acids. Epithelial cells from mice suffering from bronchial asthma (BA) secrete more EVs and suppress inflammation-induced EV production. Moreover, microarray analyses of bronchoalveolar lavage fluid have revealed that several microRNAs are useful novel biomarkers of BA. Mesenchymal stromal cell-derived EVs are possible candidates of novel BA therapy. In this review, we highlight the biologic roles of EVs in BA and review novel EV-targeted therapy to help understanding by clinicians and biologists.