Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 31; no. 1; pp. 48 - 60
• Main Authors: Torii, Sayuki, Watanabe, Yoshiyuki, Kondo, Keiko, Hisamatsu, Takashi, Sawayama, Yuichi, Fujiyoshi, Akira, Kadowaki, Sayaka, Ueshima, Hirotsugu, Yano, Yuichiro, Nakagawa, Yoshihisa, Miura, Katsuyuki, Higo, Yosuke, Kadota, Aya
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 01.01.2024
• Subjects: Obesity indices; Original; Subclinical atherosclerosis; Obesity indices; Subclinical atherosclerosis
• ISSN: 1340-3478; 1880-3873; 1880-3873
• DOI: 10.5551/jat.64096

Aim: Few studies have compared the strength in the associations of anthropometric and computed tomography (CT)-based obesity indices with coronary artery calcification (CAC), aortic artery calcification (AoAC), and aortic valve calcification (AVC).Methods: We assessed cross-sectcional associations of anthropometric and CT-based obesity indices with CAC, AoAC, and AVC. Anthropometric measures included body mass index (BMI), waist circumference, hip ircumference, waist-to-hip circumference ratio, and waist-to-height ratio in 931 men (mean age, 63.7 years) from a population-based cohort. CT images at the L4/5 level were obtained to calculate the areas of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), total adipose tissue (TAT), VAT-to-SAT ratio (VSR), and VAT-to-TAT ratio (VTR). CAC, AoAC, and AVC were quantified using the Agatston score based on CT scanning. Results: CAC, AVC, and AoAC were present in 348 (62.6%), 173 (18.6%), and 769 (82.6%) participants, respectively. In multivariable models adjusting for age, lifestyle factors, and CT types (electron beam CT and multidetector row CT), anthropometric and CT-based obesity indices were positively associated with CAC (p＜0.01). Conversely, VAT-to-SAT ratio and VAT-to-TAT ratio were positively associated with AoAC (p＜0.01). Any obesity indices were not associated with AVC.Conclusions: The strength of the associations of obesity indices with subclinical atherosclerosis varied according to the anatomically distinct atherosclerotic lesions, among men.