A Descriptive Review on the Potential Use of Diatom Biosilica as a Powerful Functional Biomaterial: A Natural Drug Delivery System

Although various chemically synthesized materials are essential in medicine, food, and agriculture, they can exert unexpected side effects on the environment and human health by releasing certain toxic chemicals. Therefore, eco-friendly and biocompatible biomaterials based on natural resources are b...

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Published inPharmaceutics Vol. 16; no. 9; p. 1171
Main Authors Kang, Sunggu, Woo, Yeeun, Seo, Yoseph, Yoo, Daehyeon, Kwon, Daeryul, Park, Hyunjun, Lee, Sang Deuk, Yoo, Hah Young, Lee, Taek
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.09.2024
MDPI
Subjects
Acids
anticancer drugs
Bioavailability
Biocompatibility
Biological products
bone regeneration
Cytotoxicity
diatom biosilica
drug delivery system
Drug delivery systems
Drugs
Microscopy
Nanoparticles
Natural resources
Patient compliance
Pharmaceuticals
Plankton
Polyamines
Polymerization
Proteins
Resveratrol
Review
surface functionalization
Toxicity
Vehicles
wound healing
diatom biosilica
bone regeneration
wound healing
drug delivery system
anticancer drugs
surface functionalization
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ISSN1999-4923
1999-4923
DOI10.3390/pharmaceutics16091171

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Summary:Although various chemically synthesized materials are essential in medicine, food, and agriculture, they can exert unexpected side effects on the environment and human health by releasing certain toxic chemicals. Therefore, eco-friendly and biocompatible biomaterials based on natural resources are being actively explored. Recently, biosilica derived from diatoms has attracted attention in various biomedical fields, including drug delivery systems (DDS), due to its uniform porous nano-pattern, hierarchical structure, and abundant silanol functional groups. Importantly, the structural characteristics of diatom biosilica improve the solubility of poorly soluble substances and enable sustained release of loaded drugs. Additionally, diatom biosilica predominantly comprises SiO2, has high biocompatibility, and can easily hybridize with other DDS platforms, including hydrogels and cationic DDS, owing to its strong negative charge and abundant silanol groups. This review explores the potential applications of various diatom biosilica-based DDS in various biomedical fields, with a particular focus on hybrid DDS utilizing them.
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These authors contributed equally to this work.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16091171