The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer

• Published in: Molecular therapy. Nucleic acids Vol. 28; pp. 397 - 407
• Main Authors: Liu, Junxia, Zhang, Qinqiu, Yang, Daolu, Xie, Fei, Wang, Zhaoxia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.06.2022; American Society of Gene & Cell Therapy; Elsevier
• Subjects: angiogenesis; anti-angiogenic therapy; cancer; cancer stem cells; drug resistance; long non-coding RNAs; MT: non-coding RNAs; Review; anti-angiogenic therapy; angiogenesis; cancer; drug resistance; cancer stem cells; long non-coding RNAs; MT: non-coding RNAs
• ISSN: 2162-2531; 2162-2531
• DOI: 10.1016/j.omtn.2022.03.012

It is well known that long non-coding RNAs (lncRNAs) play an important role in the regulation of tumor genesis and development. They can modulate gene expression of transcriptional regulation, epigenetic regulation of chromatin modification, and post-transcriptional regulation, thus influencing the biological behavior of tumors, such as cell proliferation, apoptosis, cell cycle, invasion, and migration. Tumor angiogenesis not only provides nutrients and helps excrete metabolites, but it also opens a pathway for tumor metastasis. Anti-angiogenic therapy has become one of the effective treatment methods for tumor. But its drug resistance leads to the limitation of clinical application. Recent studies have shown that lncRNAs are closely related to tumor angiogenesis and anti-angiogenic therapy resistance, which provides a new direction for tumor research. lncRNAs are expected to be new targets for tumor therapy. For the first time to our knowledge, this paper reviews advancement of lncRNAs in tumor angiogenesis and anti-angiogenic therapy resistance and further discusses their potential clinical application. [Display omitted] lncRNAs play an important role in tumor genesis and development. This paper systematically reviews the role of lncRNAs in tumor angiogenesis and antiangiogenic therapy resistance. It not only reveals the potential of lncRNAs as tumor biomarkers and therapeutic targets, but it also provides a new idea for the treatment of tumor.