Transcriptional Control of Brown Fat Development

Deconvoluting the natural pathway of BAT development has defined key molecular events, which enables researchers to manipulate the amount or activity of brown fat. We review recent advances on the transcriptional regulation of BAT development and discuss the emerging questions.

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Bibliographic Details
Published in	Cell metabolism Vol. 11; no. 4; pp. 257 - 262
Main Authors	Kajimura, Shingo, Seale, Patrick, Spiegelman, Bruce M.
Format	Journal Article
Language	English
Published	United States Elsevier Inc 07.04.2010
Subjects	Adipose Tissue, Brown - metabolism Cell Differentiation - physiology DNA-Binding Proteins - metabolism Forkhead Transcription Factors - metabolism Gene Expression Regulation - physiology Heat-Shock Proteins - metabolism Humans Models, Biological Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Thermogenesis - physiology Transcription Factors - metabolism
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ISSN	1550-4131 1932-7420 1932-7420
DOI	10.1016/j.cmet.2010.03.005

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Summary:	Deconvoluting the natural pathway of BAT development has defined key molecular events, which enables researchers to manipulate the amount or activity of brown fat. We review recent advances on the transcriptional regulation of BAT development and discuss the emerging questions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1550-4131 1932-7420 1932-7420
DOI:	10.1016/j.cmet.2010.03.005