Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer
Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to...
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| Published in | Cancers Vol. 12; no. 1; p. 216 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
15.01.2020
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2072-6694 2072-6694 |
| DOI | 10.3390/cancers12010216 |
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| Abstract | Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field. |
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| AbstractList | Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field. Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field.Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibronectin (AS-14) and heat shock cognate 71 kDa protein (AS-42) facilitated the delivery of the nanoparticles to Ehrlich carcinoma cells, and arabinogalactan (AG) promoted internalization through asialoglycoprotein receptors. Specific delivery of the aptamer-modified FeAG nanoparticles to the tumor site was confirmed by magnetic resonance imaging (MRI). After the following treatment with a low frequency alternating magnetic field, AS-FeAG caused cancer cell death in vitro and tumor reduction in vivo. Histological analyses showed mechanical disruption of tumor tissues, total necrosis, cell lysis, and disruption of the extracellular matrix. The enhanced targeted magnetic theranostics with the aptamer conjugated superparamagnetic ferroarabinogalactans opens up a new venue for making biocompatible contrasting agents for MRI imaging and performing non-invasive anti-cancer therapies with a deep penetrated magnetic field. |
| Author | Andrey K. Kirichenko Olga S. Kolovskaya Maxim V. Berezovski Galina S. Zamay Yulia Alekhina E. N. Medvedeva Yury E. Glazyrin Tatiana N. Zamay Felix N. Tomilin Kirill A. Lukyanenko Evgeny V. Morozov Sergey S. Zamay Vasily A Babkin V. N. Zabluda Ivan N. Lapin Anna S. Kichkailo N. A. Neverova Dmitri G. Fedorov Valery A. Svetlichnyi A. A. Narodov Alexey E. Sokolov |
| AuthorAffiliation | 5 Laboratory of Advanced Materials and Technology, Tomsk State University, 634050 Tomsk, Russia; 201kiop@mail.ru (I.N.L.); v_svetlichnyi@bk.ru (V.A.S.) 10 Faculty of Physics, Department of Magnetism, Lomonosov Moscow State University, 119991 Moscow, Russia; ya.alekhina@physics.msu.ru 3 Irkutsk Institute of Chemistry named after A.E. Favorsky, the Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia; babkin@irioch.irk.ru (V.A.B.); l.medwedewa2009@yandex.ru (E.N.M.); nadya_neverova@irioch.irk.ru (N.A.N.) 12 Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada 4 L.V. Kirensky Institute of Physics SB RAS—The Branch of Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, 660036 Krasnoyarsk, Russia; morozov_if@mail.ru (E.V.M.); alexeys@iph.krasn.ru (A.E.S.); zvn@iph.krasn.ru (V.N.Z.) 7 School of Engineering Physics and Radio Electronics, Siberian Federal University, 6600 |
| AuthorAffiliation_xml | – name: 10 Faculty of Physics, Department of Magnetism, Lomonosov Moscow State University, 119991 Moscow, Russia; ya.alekhina@physics.msu.ru – name: 11 School of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia – name: 2 Laboratory for Biomolecular and Medical Technologies, Faculty of Medicine, Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenecki, 660022 Krasnoyarsk, Russia; tzamay@yandex.ru (T.N.Z.); krasak.07@mail.ru (A.K.K.); narodov_a@mail.ru (A.A.N.) – name: 7 School of Engineering Physics and Radio Electronics, Siberian Federal University, 660041 Krasnoyarsk, Russia – name: 1 Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Science”, 660036 Krasnoyarsk, Russia; olga.kolovskaya@gmail.com (O.S.K.); galina.zamay@gmail.com (G.S.Z.); sergey-zamay@yandex.ru (S.S.Z.); felixnt@gmail.com (F.N.T.); kirill.lukyanenko@gmail.com (K.A.L.); yury.glazyrin@gmail.com (Y.E.G.) – name: 3 Irkutsk Institute of Chemistry named after A.E. Favorsky, the Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia; babkin@irioch.irk.ru (V.A.B.); l.medwedewa2009@yandex.ru (E.N.M.); nadya_neverova@irioch.irk.ru (N.A.N.) – name: 6 Institute of Chemistry and Chemical Technology SB RAS—The Branch of Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, 660036 Krasnoyarsk, Russia – name: 8 Research Center for Computational Design of Advanced Functional Materials (CD-FMat), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8568, Japan; d.g.fedorov@aist.go.jp – name: 4 L.V. Kirensky Institute of Physics SB RAS—The Branch of Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”, 660036 Krasnoyarsk, Russia; morozov_if@mail.ru (E.V.M.); alexeys@iph.krasn.ru (A.E.S.); zvn@iph.krasn.ru (V.N.Z.) – name: 5 Laboratory of Advanced Materials and Technology, Tomsk State University, 634050 Tomsk, Russia; 201kiop@mail.ru (I.N.L.); v_svetlichnyi@bk.ru (V.A.S.) – name: 9 School of Non-Ferrous Metals and Materials Science, Siberian Federal University, 660041 Krasnoyarsk, Russia – name: 12 Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada |
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| BackLink | https://cir.nii.ac.jp/crid/1870865118196723072$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/31952299$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1039/C6CP02186G 10.1088/1468-6996/16/2/023501 10.1021/jm301856j 10.1021/cr300068p 10.1080/15548627.2015.1075688 10.1007/s10628-005-0069-8 10.1089/nat.2013.0471 10.1002/jcc.540141112 10.1016/j.bbagen.2017.02.022 10.1016/j.omtn.2016.12.004 10.2147/IJN.S56932 10.1021/ct300849w 10.1016/j.omtn.2017.08.007 10.1021/nn901877h 10.1016/j.addr.2018.09.011 10.1038/mt.2015.108 10.1016/j.cis.2013.09.006 10.1021/ja306856y 10.1016/j.addr.2009.11.002 10.1002/cmdc.201402163 10.18632/oncotarget.24772 10.1016/S0008-6215(97)00077-3 10.1038/mtna.2014.32 10.7150/thno.11544 10.3390/nano8100810 10.1002/wcms.1322 10.3390/ph11030071 10.1088/1674-1056/24/1/014704 10.1016/j.addr.2006.09.013 10.1021/bc00030a010 10.1016/j.addr.2003.10.013 10.1016/j.tibtech.2011.03.001 10.1021/acs.jctc.9b00715 10.1021/bm5003009 10.1002/jcc.20496 10.1002/adhm.201700306 10.1038/mtna.2014.19 10.1080/07328309708006521 10.7150/thno.17089 10.1021/jp0716740 10.1016/j.biocel.2004.02.013 |
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| Contributor | Институт цветных металлов и материаловедения Институт инженерной физики и радиоэлектроники Кафедра экспериментальной физики и инновационных технологий Кафедра физической и неорганической химии |
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| Copyright | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 by the authors. 2020 |
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| Keywords | magnetic resonance imaging magnetically induced cell disruption magnetodynamic therapy superparamagnetic ferroarabinogalactans arabinogalactan drug delivery aptamers |
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| References | Engelberg (ref_21) 2018; 9 Alshaer (ref_28) 2018; 134 Fedorov (ref_39) 2017; 7 Ridi (ref_24) 2014; 207 Kruspe (ref_12) 2014; 9 Zamay (ref_17) 2017; 6 Zhi (ref_27) 2019; 102 Reddy (ref_22) 2012; 112 Kolovskaya (ref_31) 2017; 9 Joshi (ref_23) 2015; 10 Kolovskaya (ref_13) 2013; 56 Muharemagic (ref_15) 2014; 3 Wu (ref_25) 2015; 16 ref_38 Schmidt (ref_43) 1993; 14 Fedorov (ref_42) 2019; 15 Zamay (ref_16) 2005; 402 Zamay (ref_18) 2015; 23 Kim (ref_19) 2010; 4 Fedorov (ref_44) 2007; 28 Aleksandrova (ref_10) 2009; 4 Groman (ref_46) 1997; 301 Veiseh (ref_2) 2010; 62 Muharemagic (ref_14) 2012; 134 Angelakeris (ref_5) 2017; 1861 Nishimoto (ref_41) 2016; 18 Fedorov (ref_33) 2007; 111 Xie (ref_35) 2015; 11 Sun (ref_11) 2014; 3 Gobbo (ref_6) 2015; 5 Belyanina (ref_30) 2017; 7 Zamay (ref_32) 2014; 24 Lehr (ref_45) 2004; 56 Feoktistova (ref_8) 2002; 75 Cole (ref_1) 2011; 29 ref_3 Ponder (ref_37) 1997; 16 ref_29 Zhong (ref_20) 2014; 15 ref_26 Groman (ref_36) 1994; 5 Gaus (ref_40) 2013; 9 Aleksandrova (ref_9) 2004; 7 Majeski (ref_34) 2004; 36 Corot (ref_4) 2006; 58 ref_7 |
| References_xml | – volume: 18 start-page: 22047 year: 2016 ident: ref_41 article-title: The fragment molecular orbital method combined with density-functional tight-binding and the polarizable continuum model publication-title: Phys. Chem. Chem. Phys. doi: 10.1039/C6CP02186G – volume: 16 start-page: 23501 year: 2015 ident: ref_25 article-title: Recent progress on magnetic iron oxide nanoparticles: Synthesis, surface functional strategies and biomedical applications publication-title: Sci. Technol. Adv. Mater. doi: 10.1088/1468-6996/16/2/023501 – volume: 56 start-page: 1564 year: 2013 ident: ref_13 article-title: Development of Bacteriostatic DNA Aptamers for Salmonella publication-title: J. Med. Chem. doi: 10.1021/jm301856j – volume: 112 start-page: 5818 year: 2012 ident: ref_22 article-title: Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications publication-title: Chem. Rev. doi: 10.1021/cr300068p – volume: 11 start-page: 1623 year: 2015 ident: ref_35 article-title: Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA publication-title: Autophagy doi: 10.1080/15548627.2015.1075688 – volume: 402 start-page: 197 year: 2005 ident: ref_16 article-title: Change in physicochemical parameters of membranes of Ehrlich ascite adenocarcinoma in the course of tumor growth publication-title: Dokl. Biochem. Biophys. doi: 10.1007/s10628-005-0069-8 – volume: 24 start-page: 160 year: 2014 ident: ref_32 article-title: DNA-Aptamer Targeting Vimentin for Tumor Therapy In Vivo publication-title: Nucleic Acid Ther. doi: 10.1089/nat.2013.0471 – volume: 14 start-page: 1347 year: 1993 ident: ref_43 article-title: General atomic and molecular electronic structure system publication-title: J. Comput. Chem. doi: 10.1002/jcc.540141112 – volume: 1861 start-page: 1642 year: 2017 ident: ref_5 article-title: Magnetic nanoparticles: A multifunctional vehicle for modern theranostics publication-title: Biochim. Biophys. Acta Gen. Subj. doi: 10.1016/j.bbagen.2017.02.022 – volume: 6 start-page: 150 year: 2017 ident: ref_17 article-title: DNA Aptamers for the Characterization of Histological Structure of Lung Adenocarcinoma publication-title: Mol. Ther. Nucleic Acids doi: 10.1016/j.omtn.2016.12.004 – volume: 10 start-page: 1001 year: 2015 ident: ref_23 article-title: Polymeric nanoparticles for targeted treatment in oncology: Current insights publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S56932 – volume: 9 start-page: 338 year: 2013 ident: ref_40 article-title: Parametrization and Benchmark of DFTB3 for Organic Molecules publication-title: J. Chem. Theory Comput. doi: 10.1021/ct300849w – volume: 9 start-page: 12 year: 2017 ident: ref_31 article-title: Aptamer-Targeted PlasmonicPhotothermal Therapy of Cancer publication-title: Mol. Ther. Nucleic Acids doi: 10.1016/j.omtn.2017.08.007 – volume: 4 start-page: 3689 year: 2010 ident: ref_19 article-title: A Drug-Loaded Aptamer−Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer publication-title: ACS Nano doi: 10.1021/nn901877h – volume: 134 start-page: 122 year: 2018 ident: ref_28 article-title: Aptamer-guided nanomedicines for anticancer drug delivery publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2018.09.011 – volume: 23 start-page: 1486 year: 2015 ident: ref_18 article-title: Aptamers Selected to Postoperative Lung Adenocarcinoma Detect Circulating Tumor Cells in Human Blood publication-title: Mol. Ther. doi: 10.1038/mt.2015.108 – volume: 207 start-page: 3 year: 2014 ident: ref_24 article-title: Magneto-responsive nanocomposites: Preparation and integration of magnetic nanoparticles into films, capsules, and gels publication-title: Adv. Colloid Interface Sci. doi: 10.1016/j.cis.2013.09.006 – volume: 134 start-page: 17168 year: 2012 ident: ref_14 article-title: Anti-Fab Aptamers for Shielding Virus from Neutralizing Antibodies publication-title: J. Am. Chem. Soc. doi: 10.1021/ja306856y – volume: 62 start-page: 284 year: 2010 ident: ref_2 article-title: Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2009.11.002 – volume: 9 start-page: 1998 year: 2014 ident: ref_12 article-title: Aptamers as Drug Delivery Vehicles publication-title: ChemMedChem doi: 10.1002/cmdc.201402163 – volume: 9 start-page: 20993 year: 2018 ident: ref_21 article-title: Cancer cell-selective, clathrin-mediated endocytosis of aptamer decorated nanoparticles publication-title: Oncotarget doi: 10.18632/oncotarget.24772 – volume: 301 start-page: 69 year: 1997 ident: ref_46 article-title: Development of an immunoassay for larch arabinogalactan and its use in the detection of larch arabinogalactan in rat blood publication-title: Carbohydr. Res. doi: 10.1016/S0008-6215(97)00077-3 – volume: 7 start-page: 139 year: 2004 ident: ref_9 article-title: Synthesis of nanosized particles with magnetic properties for biomedical purposes publication-title: Phys. Mesomech. – volume: 3 start-page: e182 year: 2014 ident: ref_11 article-title: Oligonucleotide aptamers: New tools for targeted cancer therapy publication-title: Mol. Ther. Nucleic Acids doi: 10.1038/mtna.2014.32 – volume: 5 start-page: 1249 year: 2015 ident: ref_6 article-title: Magnetic Nanoparticles in Cancer Theranostics publication-title: Theranostics doi: 10.7150/thno.11544 – ident: ref_26 doi: 10.3390/nano8100810 – volume: 7 start-page: e1322 year: 2017 ident: ref_39 article-title: The fragment molecular orbital method: Theoretical development, implementation in GAMESS, and applications publication-title: Wiley Interdiscip. Rev. Comput. Mol. Sci. doi: 10.1002/wcms.1322 – ident: ref_29 doi: 10.3390/ph11030071 – ident: ref_3 doi: 10.1088/1674-1056/24/1/014704 – volume: 58 start-page: 1471 year: 2006 ident: ref_4 article-title: Recent advances in iron oxide nanocrystal technology for medical imaging publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2006.09.013 – volume: 102 start-page: 13 year: 2019 ident: ref_27 article-title: Targeting strategies for superparamagnetic iron oxide nanoparticles in cancer therapy publication-title: ActaBiomater. – volume: 75 start-page: 1951 year: 2002 ident: ref_8 article-title: Radiographic study of iron-containing arabinogalactan derivatives publication-title: J. Appl. Chem. – volume: 5 start-page: 547 year: 1994 ident: ref_36 article-title: Arabinogalactan for Hepatic Drug Delivery publication-title: Bioconjug. Chem. doi: 10.1021/bc00030a010 – volume: 4 start-page: 1 year: 2009 ident: ref_10 article-title: Magnetic Activity of Nanostructured Hybrid Composites publication-title: Electron. J. Phase Transit. Ordered States New Mater. – volume: 56 start-page: 419 year: 2004 ident: ref_45 article-title: Lectins and glycoconjugates in drug delivery and targeting publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2003.10.013 – volume: 29 start-page: 323 year: 2011 ident: ref_1 article-title: Cancer theranostics: The rise of targeted magnetic nanoparticles publication-title: Trends Biotechnol. doi: 10.1016/j.tibtech.2011.03.001 – volume: 15 start-page: 5404 year: 2019 ident: ref_42 article-title: Solvent Screening in Zwitterions Analyzed with the Fragment Molecular Orbital Method publication-title: J. Chem. Theory Comput. doi: 10.1021/acs.jctc.9b00715 – volume: 15 start-page: 1955 year: 2014 ident: ref_20 article-title: Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy publication-title: Biomacromolecules doi: 10.1021/bm5003009 – ident: ref_38 – volume: 28 start-page: 222 year: 2007 ident: ref_44 article-title: Pair interaction energy decomposition analysis publication-title: J. Comput. Chem. doi: 10.1002/jcc.20496 – ident: ref_7 doi: 10.1002/adhm.201700306 – volume: 3 start-page: e167 year: 2014 ident: ref_15 article-title: Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies publication-title: Mol. Ther. Nucleic Acids doi: 10.1038/mtna.2014.19 – volume: 16 start-page: 195 year: 1997 ident: ref_37 article-title: Arabinogalactan from Western Larch, Part II.; A Reversible Order-Disorder Transition publication-title: J. Carbohydr. Chem. doi: 10.1080/07328309708006521 – volume: 7 start-page: 3326 year: 2017 ident: ref_30 article-title: In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field publication-title: Theranostics doi: 10.7150/thno.17089 – volume: 111 start-page: 6904 year: 2007 ident: ref_33 article-title: Extending the Power of Quantum Chemistry to Large Systems with the Fragment Molecular Orbital Method publication-title: J. Phys. Chem. A doi: 10.1021/jp0716740 – volume: 36 start-page: 2435 year: 2004 ident: ref_34 article-title: Mechanisms of chaperone-mediated autophagy publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2004.02.013 |
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| Title | Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer |
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