Multidisciplinary Management Strategy for Incidental Cystic Lesions of the Pancreas

• Published in: Journal of the American College of Surgeons Vol. 211; no. 2; pp. 205 - 215
• Main Authors: Bose, Debashish, MD, PhD, Tamm, Eric, MD, Liu, Jun, MS, Marcal, Leonardo, MD, Balachandran, Aparna, MD, Bhosale, Priya, MD, Fleming, Jason B., MD, FACS, Lee, Jeffrey E., MD, FACS, Evans, Douglas B., MD, FACS, Hwang, Rosa F., MD, FACS
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2010; Elsevier
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biopsy, Fine-Needle - methods; Diagnosis, Differential; Endosonography - methods; Female; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Pancreatectomy - methods; Pancreatic Cyst - diagnosis; Pancreatic Cyst - mortality; Pancreatic Cyst - therapy; Practice Guidelines as Topic; Precancerous Conditions; Prognosis; Retrospective Studies; Surgery; Texas - epidemiology; Tomography, X-Ray Computed - methods; Tumors; Young Adult; Texas; SCA; serous cystadenocarcinoma; mucinous cystic neoplasm; multidetector CT; EUS; endoscopic ultrasonography; FNA; MCN; fine-needle aspiration; IPMN; intraductal papillary mucinous neoplasm; MDCT; Pancreatic cyst; Medicine; Clinical management; Treatment; Surgery; Digestive diseases; Strategy; Multidisciplinary; Pancreatic disease
• ISSN: 1072-7515; 1879-1190; 1879-1190
• DOI: 10.1016/j.jamcollsurg.2010.03.034

Background At our institution, incidental pancreatic cysts are frequently identified in asymptomatic patients undergoing routine imaging for staging of nonpancreatic malignancies. Management of these patients is unclear because a small but significant number of incidental pancreatic cysts are malignant. Study Design Our institutional database was reviewed for patients with ICD-9 codes for pancreatic cysts from 1980 to 2005. Clinicopathologic factors, including CT and endoscopic ultrasound (EUS) characteristics and management strategies, were analyzed. Results Over 25 years, 942 patients were identified with pancreatic cysts. Excluding those with symptoms or pseudocysts, 350 patients remained with incidental pancreatic cysts. Mean overall survival was 41.4 months (mean follow-up 32.7 months). Forty-one patients underwent resection, of whom 38 (92.7%) had premalignant or malignant pathology. Univariate analysis of variables predicting pathologic premalignant or malignant diagnosis identified pancreatic neck or body location as significant factors. Conclusions These data suggest that most incidental pancreatic cysts can be managed nonoperatively using a selective strategy based on detailed review of CT imaging and EUS findings.