Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [11C]-D-deprenyl PET/CT
[Display omitted] •An increased [11C]-D-deprenyl uptake is shown in painful locations after ankle sprain.•Patients experiencing persistent pain had prolonged peripheral D-deprenyl uptake.•The described method can visualize, quantify and follow pain generating processes.•Such an objective correlate m...
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Published in | Scandinavian journal of pain Vol. 17; no. 1; pp. 418 - 424 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Elsevier B.V
01.10.2017
De Gruyter |
Subjects | |
Online Access | Get full text |
ISSN | 1877-8860 1877-8879 1877-8879 |
DOI | 10.1016/j.sjpain.2017.10.008 |
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Summary: | [Display omitted]
•An increased [11C]-D-deprenyl uptake is shown in painful locations after ankle sprain.•Patients experiencing persistent pain had prolonged peripheral D-deprenyl uptake.•The described method can visualize, quantify and follow pain generating processes.•Such an objective correlate may represent a progress in pain research and management.
Positron emission tomography (PET) with the radioligand [11C]-D-deprenyl has shown increased signal at location of pain in patients with rheumatoid arthritis and chronic whiplash injury. The binding site of [11C]-D-deprenyl in peripheral tissues is suggested to be mitochondrial monoamine oxidase in cells engaged in post-traumatic inflammation and tissue repair processes. The association between [11C]-D-deprenyl uptake and the transition from acute to chronic pain remain unknown. Further imaging studies of musculoskeletal pain at the molecular level would benefit from establishing a clinical model in a common and well-defined injury in otherwise healthy and drug-naïve subjects. The aim of this study was to investigate if [11C]-D-deprenyl uptake would be acutely elevated in unilateral ankle sprain and if tracer uptake would be reduced as a function of healing, and correlated with pain localizations and pain experience.
Eight otherwise healthy patients with unilateral ankle sprain were recruited at the emergency department. All underwent [11C]-D-deprenyl PET/CT in the acute phase, at one month and 6–14 months after injury.
Acute [11C]-D-deprenyl uptake at the injury site was a factor of 10.7 (range 2.9–37.3) higher than the intact ankle. During healing, [11C]-D-deprenyl uptake decreased, but did not normalize until after 11 months. Patients experiencing persistent pain had prolonged [11C]-D-deprenyl uptake in painful locations.
The data provide further support that [11C]-D-deprenyl PET can visualize, quantify and follow processes in peripheral tissue that may relate to soft tissue injuries, inflammation and associated nociceptive signaling. Such an objective correlate would represent a progress in pain research, as well as in clinical pain diagnostics and management. |
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ISSN: | 1877-8860 1877-8879 1877-8879 |
DOI: | 10.1016/j.sjpain.2017.10.008 |