Diabetic myonecrosis in a patient with hepatic cirrhosis: a case report and review of the literature

• Published in: Journal of medical case reports Vol. 3; no. 1; p. 9305
• Main Authors: Mancillas-Adame, Leonardo G, González-González, Jose G, Jáquez-Quintana, Joel O, Cardoza-Torres, Myrna A, García, Alberto de la Fuente
• Format: Journal Article
• Language: English
• Published: London BioMed Central 30.11.2009; BioMed Central Ltd; BMC
• Subjects: Care and treatment; Case Report; Case studies; Complications and side effects; Diabetics; Diagnosis; Diseases; Family Medicine; General Practice; Internal Medicine; Liver cirrhosis; Medical examination; Medicine; Medicine & Public Health; Muscles; Necrosis; Patient outcomes; Primary Care Medicine; Public Health; Risk factors; Surgical Oncology; Mexico; Hepatic Cirrhosis; Spontaneous Bacterial Peritonitis; Left Thigh; Hepatic Encephalopathy; Hyperintense Signal
• ISSN: 1752-1947; 1752-1947
• DOI: 10.1186/1752-1947-3-9305

Introduction Diabetic myonecrosis was first reported by Angervall and Stener in 1965. In its classical clinical expression, it affects type 1 diabetes mellitus patients with long-standing poor metabolic control and advanced chronic microvascular complications. A sudden-onset of severe pain in the region of the involved muscle, usually the quadriceps, is the typical clinical manifestation. Magnetic resonance imaging (MRI) confirms the clinical diagnosis; in some cases of diagnostic uncertainty, a muscle biopsy may be required. Case Presentation We present the case of a 38 year-old Hispanic male from Mexico, with alcohol-induced hepatic cirrhosis (Child-Pugh C/MELD 45) and type 2 diabetes mellitus admitted to the emergency room due to hepatic encephalopathy with intense pain and an increase in volume of the left thigh. MRI showed edema and inflammatory changes of the quadriceps muscle with a hyperintense signal on T2-weighted images; in addition, there was a subacute hematoma. Conclusion To the best of our knowledge, this is the first case of diabetic myonecrosis associated with and complicated by advanced hepatic cirrhosis reported in the literature.