Neutrophil-to-lymphocyte ratio as a predictive marker of metabolic syndrome

• Published in: Medicine (Baltimore) Vol. 98; no. 43; p. e17537
• Main Authors: Liu, Chuan-Chuan, Ko, Hung-Ju, Liu, Wan-Shan, Hung, Chung-Lieh, Hu, Kuang-Chun, Yu, Lo-Yip, Shih, Shou-Chuan
• Format: Journal Article
• Language: English
• Published: United States the Author(s). Published by Wolters Kluwer Health, Inc 01.10.2019; Wolters Kluwer Health
• Subjects: Adult; Biomarkers - blood; Female; Humans; Lymphocyte Count; Lymphocytes - metabolism; Male; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Metabolic Syndrome - etiology; Middle Aged; Neutrophils - metabolism; Observational Study; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment - methods; Risk Factors; ROC Curve
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000017537

Neutrophil-to-lymphocyte ratio (NLR) serves as a strong prognostic indicator for patients suffering from various diseases. Neutrophil activation promotes the recruitment of a number of different cell types that are involved in acute and chronic inflammation and are associated with cancer treatment outcome. Measurement of NLR, an established inflammation marker, is cost-effective, and it is likely that NLR can be used to predict the development of metabolic syndrome (MS) at an early stage. MS scores range from 1 to 5, and an elevated MS score indicates a greater risk for MS. Monitoring NLR can prevent the risk of MS.A total of 34,013 subjects were enrolled in this study. The subjects (score 0-5) within the 6 groups were classified according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and all anthropometrics, laboratory biomarkers, and hematological measurements were recorded. For the 6 groups, statistical analysis and receiver operating characteristic (ROC) curves were used to identify the development of MS.Analysis of the ROC curve indicated that NLR served as a good predictor for MS. An MS score of 1 to 2 yielded an acceptable discrimination rate, and these rates were even higher for MS scores of 3 to 5 (P < .001), where the prevalence of MS was 30.8%.NLR can be used as a prognostic marker for several diseases, including those associated with MS.