Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from α-Hydroxy Ketones and Cyano Compounds

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 8; p. 1832
• Main Authors: Zeng, Yu, Yang, Shi-Hang, Guo, Ji-Lin, Li, Yun, Lin, Ting, Wang, Zhao-Yang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.04.2025; MDPI
• Subjects: Catalysis; cyano compounds; Ethanol; Fluorides; Furans; green synthesis; Investigations; Ketones; Metal catalysts; metal-free catalysis; Natural products; Optimization; Oxidation; Potassium; Solvents; Temperature; tetrasubstituted furans; α-hydroxy ketones; Massachusetts; metal-free catalysis; tetrasubstituted furans; green synthesis; α-hydroxy ketones; cyano compounds
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules30081832

A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction of α-hydroxy ketones and cyano compounds. The reaction proceeds under relatively mild conditions, utilizes readily available starting materials, and exhibits good functional group tolerance and high yields. Notably, this reaction obviates the need for expensive metal catalysts and introduces crucial functional groups such as amino and cyano moieties. Furthermore, it avoids the prerequisite functionalization of substrates, thereby enhancing atomic economy.