Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease

• Published in: Movement disorders Vol. 30; no. 6; pp. 862 - 866
• Main Authors: Bronstein, Jeff M., Paul, Kimberly, Yang, Laurice, Haas, Richard H., Shults, Clifford W., Le, Thuy, Ritz, Beate
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2015; Wiley Subscription Services, Inc
• Subjects: Aged; Blood Platelets - drug effects; Blood Platelets - enzymology; Case-Control Studies; complex I; electron transport chain; Electron Transport Chain Complex Proteins - metabolism; Electron Transport Complex I - metabolism; Electron Transport Complex III - metabolism; Environmental Exposure - adverse effects; Female; Geographic Information Systems - statistics & numerical data; Humans; Male; Middle Aged; Mitochondria - drug effects; Mitochondria - enzymology; Movement disorders; NADPH-Ferrihemoprotein Reductase - metabolism; Parkinson Disease - etiology; Parkinson Disease - metabolism; Pesticides - toxicity; Risk Factors; complex I; electron transport chain
• ISSN: 0885-3185; 1531-8257; 1531-8257
• DOI: 10.1002/mds.26164

Background Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear. Methods Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population‐based case‐control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry. Results In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis. Conclusions Electron transport chain (ETC) activity is not altered in PD in this well‐characterized cohort when compared with community‐matched controls but appears to be affected by environmental toxins, such as mitochondria‐inhibiting pesticides. © 2015 International Parkinson and Movement Disorder Society