Stretching the Stamp: A Flexible Approach to the Fabrication of Miniaturized DNA Arrays

Miniaturized DNA arrays are obtained by using elastic deformation in conjunction with conventional pin spotting. The process takes advantage of elastomers that offer high mechanical flexibility, which makes it possible to achieve substantial miniaturization in a single step (see image).

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Bibliographic Details
Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 5; no. 22; pp. 2514 - 2518
Main Authors Geissler, Matthias, Roy, Emmanuel, Deneault, Jean-Sébastien, Arbour, Mélanie, Diaz-Quijada, Gerardo A., Nantel, André, Veres, Teodor
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.11.2009
WILEY‐VCH Verlag
Subjects
Biocompatible Materials - chemistry
DNA arrays
elastic deformation
Elastic Modulus
Elastomers - chemistry
Equipment Design
Equipment Failure Analysis
Materials Testing
microspotting
Miniaturization
Nanotechnology - instrumentation
Oligonucleotide Array Sequence Analysis - instrumentation
soft lithography
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ISSN1613-6810
1613-6829
1613-6829
DOI10.1002/smll.200900862

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Summary:Miniaturized DNA arrays are obtained by using elastic deformation in conjunction with conventional pin spotting. The process takes advantage of elastomers that offer high mechanical flexibility, which makes it possible to achieve substantial miniaturization in a single step (see image).
Bibliography:ark:/67375/WNG-VG655KCS-L
ArticleID:SMLL200900862
This work was supported by Genome Canada and Génome Québec. We thank our colleagues Jean-Guy Allard, Hélène Roberge, and François Normandin for useful discussion and technical assistance. We are grateful to Dr. Régis Peytavi (Université Laval), Prof. Michel G. Bergeron (Université Laval), and Dr. Michel M. Dumoulin (IMI/CNRC) for their support.
istex:CCEF1FE1F26D8E21B27136260B4A696DFD7C0CE2
This work was supported by Genome Canada and Génome Québec. We thank our colleagues Jean‐Guy Allard, Hélène Roberge, and François Normandin for useful discussion and technical assistance. We are grateful to Dr. Régis Peytavi (Université Laval), Prof. Michel G. Bergeron (Université Laval), and Dr. Michel M. Dumoulin (IMI/CNRC) for their support.
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ISSN:1613-6810
1613-6829
1613-6829
DOI:10.1002/smll.200900862