GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 14; no. 40; pp. e1801900 - n/a
• Main Authors: Giménez‐Marqués, Mónica, Bellido, Elena, Berthelot, Thomas, Simón‐Yarza, Teresa, Hidalgo, Tania, Simón‐Vázquez, Rosana, González‐Fernández, África, Avila, José, Asensio, Maria Carmen, Gref, Ruxandra, Couvreur, Patrick, Serre, Christian, Horcajada, Patricia
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2018; Wiley-VCH Verlag
• Subjects: Anticancer properties; Biocompatibility; biomedical applications of MOFs; Biomedical materials; Biopolymers; Chemical Sciences; Coating effects; Colloid chemistry; furtiveness; Grafting; Hyaluronic acid; Iron; Material chemistry; Medicinal Chemistry; Metal-organic frameworks; MOF; Nanoparticles; Nanotechnology; Organic chemistry; PEGylated nanoparticles; Phagocytosis; Polyethylene glycol; Porosity; Stability; Toxicity; furtiveness; biomedical applications of MOFs; PEGylated nanoparticles; MOF
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.201801900

Controlling the outer surface of nanometric metal–organic frameworks (nanoMOFs) and further understanding the in vivo effect of the coated material are crucial for the convenient biomedical applications of MOFs. However, in most studies, the surface modification protocol is often associated with significant toxicity and/or lack of selectivity. As an alternative, how the highly selective and general grafting GraftFast method leads, through a green and simple process, to the successful attachment of multifunctional biopolymers (polyethylene glycol (PEG) and hyaluronic acid) on the external surface of nanoMOFs is reported. In particular, effectively PEGylated iron trimesate MIL‐100(Fe) nanoparticles (NPs) exhibit suitable grafting stability and superior chemical and colloidal stability in different biofluids, while conserving full porosity and allowing the adsorption of bioactive molecules (cosmetic and antitumor agents). Furthermore, the nature of the MOF–PEG interaction is deeply investigated using high‐resolution soft X‐ray spectroscopy. Finally, a cell penetration study using the radio‐labeled antitumor agent gemcitabine monophosphate (3H‐GMP)‐loaded MIL‐100(Fe)@PEG NPs shows reduced macrophage phagocytosis, confirming a significant in vitro PEG furtiveness. A green and highly selective general GraftFast method is reported for the successful attachment of biopolymers on the external surface of nanometric metal–organic frameworks. PEGylated MIL‐100(Fe) nanoparticles exhibit superior chemical and colloidal stability, allowing the adsorption of bioactive molecules. A cell penetration study using the antitumor agent gemcitabine monophosphate‐loaded MIL‐100(Fe)@polyethylene glycol (PEG) confirms a significant in vitro PEG furtiveness.