A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy
Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae ( M. leprae ), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associ...
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Published in | Nature communications Vol. 7; no. 1; pp. 13760 - 8 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
15.12.2016
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
ISSN | 2041-1723 2041-1723 |
DOI | 10.1038/ncomms13760 |
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Summary: | Leprosy, a chronic infectious disease, results from the uncultivable pathogen
Mycobacterium leprae
(
M. leprae
), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (
P
=1.94 × 10
−8
, OR=0.89), rs4720118 on 7p14.3 (
P
=3.85 × 10
−10
, OR=1.16), rs55894533 on 8p23.1 (
P
=5.07 × 10
−11
, OR=1.15) and rs10100465 on 8q24.11 (
P
=2.85 × 10
−11
, OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy.
Previous studies have shown genetic associations between leprosy and 18 different genes/loci. Here, Wang and colleagues perform genome-wide association study in Han Chinese leprosy patients and describe four novel loci to be associated to the disease. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work |
ISSN: | 2041-1723 2041-1723 |
DOI: | 10.1038/ncomms13760 |