A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy

Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae ( M. leprae ), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associ...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 7; no. 1; pp. 13760 - 8
Main Authors Wang, Zhenzhen, Sun, Yonghu, Fu, Xi’an, Yu, Gongqi, Wang, Chuan, Bao, Fangfang, Yue, Zhenhua, Li, Jianke, Sun, Lele, Irwanto, Astrid, Yu, Yongxiang, Chen, Mingfei, Mi, Zihao, Wang, Honglei, Huai, Pengcheng, Li, Yi, Du, Tiantian, Yu, Wenjun, Xia, Yang, Xiao, Hailu, You, Jiabao, Li, Jinghui, Yang, Qing, Wang, Na, Shang, Panpan, Niu, Guiye, Chi, Xiaojun, Wang, Xiuhuan, Cao, Jing, Cheng, Xiujun, Liu, Hong, Liu, Jianjun, Zhang, Furen
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.12.2016
Nature Publishing Group
Nature Portfolio
Subjects
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/ncomms13760

Cover

More Information
Summary:Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae ( M. leprae ), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 ( P =1.94 × 10 −8 , OR=0.89), rs4720118 on 7p14.3 ( P =3.85 × 10 −10 , OR=1.16), rs55894533 on 8p23.1 ( P =5.07 × 10 −11 , OR=1.15) and rs10100465 on 8q24.11 ( P =2.85 × 10 −11 , OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy. Previous studies have shown genetic associations between leprosy and 18 different genes/loci. Here, Wang and colleagues perform genome-wide association study in Han Chinese leprosy patients and describe four novel loci to be associated to the disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors contributed equally to this work
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms13760